Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery DOI Creative Commons
Petr Pošta, Andreas Kolk, Kristýna Pivovarčíková

и другие.

Diagnostics, Год журнала: 2023, Номер 13(20), С. 3161 - 3161

Опубликована: Окт. 10, 2023

In our study, the effect of use autofluorescence (Visually Enhanced Lesion Scope—VELscope) on increasing success rate surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis tested a group 122 patients suffering from OSCC, randomized into study and control enrolled after meeting inclusion criteria. The preoperative checkup via VELscope, accompanied by marking range loss fluorescence group, performed before surgery. We developed unique mucosal tattoo technique for this purpose. histopathological results treatment, i.e., margin status, were then compared. we achieved pathological free (pFM) 55 patients, close (pCM) 6 cases, encountered no cases positive (pPM) layer. comparison, revealed pPM 7 pCM 14 pFM 40 all This demonstrated that assessment surroundings OSCC increased ability to achieve resection 4.8 times terms lateral margins.

Язык: Английский

Recent Progress in the Development of Glucose Transporter (GLUT) Inhibitors DOI
Yuxuan Wang,

Zhiqiang Sun,

Zean Zhao

и другие.

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Cancer cells exhibit an accelerated glucose uptake and glycolysis. The transmembrane of requires specific carrier proteins, such as transporters (GLUTs) sodium-coupled cotransporters (SGLTs). GLUTs transport independently the energy supply have become promising targets for cancer therapy. This Perspective mainly focuses on current research progress design strategy GLUT inhibitors, particularly those targeting class I (GLUT1–4). To best our knowledge, this is first systematic interpretation progress, opportunities, challenges faced in development inhibitors from a medicinal chemistry perspective. We hope that will provide insights into offering feasible approach to

Язык: Английский

Процитировано

2
Current nano drug delivery systems for targeting head and neck squamous cell carcinoma microenvironment: a narrative review DOI
Aref Faraji-Barhagh, Samaneh Jahandar-Lashaki, Rana Jahanban-­Esfahlan

и другие.

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Апрель 8, 2025

Язык: Английский

Процитировано

0
The Possibility of Plasma Membrane Transporters as Drug Targets in Oral Cancers DOI Open Access
Chiharu Sogawa,

Katsumitsu Shimada,

Keisuke Nakano

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4310 - 4310

Опубликована: Май 1, 2025

Plasma membrane transporters are increasingly recognized as potential drug targets for oral cancer, particularly squamous cell carcinoma (OSCC). These play crucial roles in cancer metabolism, resistance, and the tumor microenvironment, making them attractive therapeutic intervention. Among two main families of plasma transporters, ATP-binding cassette (ABC) have long been known to be involved efflux contribute chemoresistance cells. On other hand, solute carriers (SLCs) also a family that facilitate transport various substrates, including nutrients drugs, recently shown chemosensitivity, proliferation. SLC identified biomarkers targets, their expression profiles suggest they could utilized precision oncology approaches. We summarize previous reports on role ABC discuss targets.

Язык: Английский

Процитировано

0
Fluorescence Imaging-Assessed Surgical Margin Detection in Head and Neck Oncology by Passive and Active Targeting DOI Creative Commons
Luca Dirheimer,

Sophie Cortese,

Gilles Dolivet

и другие.

Molecular Diagnosis & Therapy, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Surgery remains the gold standard in management of head and neck squamous cell carcinoma (HNSCC). However, anatomical complexity these cancers, combined with difficulty discriminating between healthy cancerous tissue detection microlesions, complicates tumor resection, resulting positive surgical margins, which are associated a poor patient prognosis. Fluorescence-guided surgery (FGS) has emerged as promising technique HNSCC, improving resection margin assessment. FGS strategies can be roughly divided into three approaches; namely, natural autofluorescence, passive delivery fluorescent contrast agents, active targeting. This review provides comprehensive overview advances made particularly aiming to improve Recently, field shown results by addressing agents targeted overexpressed epidermal growth factor receptor (EGFR), both preclinical clinical settings. The identification new targets such αVβ6 integrin, uPAR, PARP1, so on, well development key steps further making it an essential tool precision oncology. Among these, was demonstrated studies, integrin is emerging target due its high specific expression margins.

Язык: Английский

Процитировано

0
Recent advances of photodiagnosis and treatment for head and neck squamous cell carcinoma DOI Creative Commons
Yining Zhang,

Zhenfang Li,

C. Zhang

и другие.

Neoplasia, Год журнала: 2024, Номер 60, С. 101118 - 101118

Опубликована: Дек. 24, 2024

Язык: Английский

Процитировано

2
The NXDC-MEN-301 Study on 5-ALA for Meningiomas Surgery: An Innovative Study Design for the Assessing the Benefit of Intra-Operative Fluorescence Imaging DOI Creative Commons
Walter Stummer, Markus Holling, Bernard R. Bendok

и другие.

Brain Sciences, Год журнала: 2022, Номер 12(8), С. 1044 - 1044

Опубликована: Авг. 6, 2022

5-aminolevulinic acid (5-ALA; GleolanTM, NX Development Corps., Lexington, USA) is approved for fluorescence-guided resections of suspected malignant gliomas. Experience has demonstrated that meningiomas also show fluorescence, which may be a useful surgical adjunct. We present an innovative design multi-center, prospective study to determine the clinical safety and potential benefit resection with utmost bias reduction.All patients meningioma (all grades) receive GleolanTM 20 mg/kg 2-4 h prior surgery supported by fluorescence excitation from blue light source (Blue400, Zeiss Meditech, Oberkochen, Germany; FL400, Leica Microsystems, Heerbrugg, Switzerland). Surgeons are asked whether residual tumor can observed fluoresce under (BL) after no longer recognizable using conventional illumination at end surgery. In addition, when faced tissues uncertain tissue type (so-called "indeterminate" tissue), this records how often surgeons make correct decision based on influences strategy. The primary endpoint percentage in whom one these two benefits observed. Other endpoints include diagnostic accuracy compared white (WL) versus correlative histology. For reduction, pertinent data derived videos reviewed independent reviewers blinded surgeons' assessments status. Data will included approximately 100 participants completing 15 centers United States, Germany, Austria.As May 2022, 88 have completed study. No adverse signal been detected.Preliminary confirm feasibility our design. Accrual targeted completion third quarter 2022.

Язык: Английский

Процитировано

8
Unraveling the complexity of histone-arginine methyltransferase CARM1 in cancer: From underlying mechanisms to targeted therapeutics DOI

Wenke Jin,

Jin Zhang,

Xiya Chen

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2023, Номер 1878(4), С. 188916 - 188916

Опубликована: Май 15, 2023

Язык: Английский

Процитировано

4
A pH-sensitive supermolecular fluorescent probe for albumin-mediated cell imaging DOI Open Access

XU Shao-hu,

Kai-Li Chang,

Xian-Ting Yan

и другие.

Tetrahedron, Год журнала: 2023, Номер 150, С. 133770 - 133770

Опубликована: Дек. 1, 2023

Язык: Английский

Процитировано

3
Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery DOI Open Access
Petr Pošta, Andreas Kolk, Kristýna Pivovarčíková

и другие.

Опубликована: Июнь 13, 2023

The influence of preoperative examination oral squamous cell carcinoma (OSCC) mucosal surrounding by VELscope (Visually Enhanced Lesion Scope) on the radicality surgical treatment OSCC was goal this study.It is first analysis its kind with a total number 122 patients suffering from homogenous distribution different tumor stages randomized into study and control group enrolled in our after meeting inclusion criteria. checkup accompanied marking range loss fluorescence performed before surgery. We have developed unique tattoo technique for purpose. pathohistological results treatment, i.e. margin status, were then compared. achieved pathological free (pFM) 55 patients, close (pCM) 6 cases we encountered no case positive (pPM) layer group. In comparison, revealed pPM 7 cases, pCM 14 pFM 40 all layer. This proved that autofluorescence evaluation can enhance ability to reach resection.

Язык: Английский

Процитировано

2
Clinical Experience with Autofluorescence Guided Oral Squamous Cell Carcinoma Surgery DOI Creative Commons
Petr Pošta, Andreas Kolk, Kristýna Pivovarčíková

и другие.

Diagnostics, Год журнала: 2023, Номер 13(20), С. 3161 - 3161

Опубликована: Окт. 10, 2023

In our study, the effect of use autofluorescence (Visually Enhanced Lesion Scope—VELscope) on increasing success rate surgical treatment in oral squamous carcinoma (OSCC) was investigated. Our hypothesis tested a group 122 patients suffering from OSCC, randomized into study and control enrolled after meeting inclusion criteria. The preoperative checkup via VELscope, accompanied by marking range loss fluorescence group, performed before surgery. We developed unique mucosal tattoo technique for this purpose. histopathological results treatment, i.e., margin status, were then compared. we achieved pathological free (pFM) 55 patients, close (pCM) 6 cases, encountered no cases positive (pPM) layer. comparison, revealed pPM 7 pCM 14 pFM 40 all This demonstrated that assessment surroundings OSCC increased ability to achieve resection 4.8 times terms lateral margins.

Язык: Английский

Процитировано

1