Association and mediation between circulating inflammatory proteins and skin fibrosis

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Март 18, 2025

Skin fibrosis is a dermal lesion associated with inflammatory factors. However, the exact causal relationship between circulating proteins (CIPs) and skin remains unclear. To investigate this potential association mediated effect, Mendelian randomization (MR) two-step MR were used. Summary statistics from genome-wide studies (GWAS) extracted GWAS Catalog for CIPs, blood metabolites (BMs), fibrosis. Two-sample reverse conducted to determine effect of CIPs on Two-step was then performed role BMs in mediating Reverse analysis confirm unidirectional causality BMs, as well Bidirectional revealed negative associations levels T-cell surface glycoprotein CD6 isoform (odds ratio [OR] 0.670 [95% confidence interval [CI] 0.472, 0.951], p = 0.025), Delta Notch-like epidermal growth factor-related receptor (OR 0.779 CI 0.609, 0.998], 0.048), Interleukin-10 subunit beta 0.541 0.332, 0.884], 0.014). There positive Fibroblast factor 21 2.276 1.064, 4.870], 0.034). showed that Retinol (Vitamin A) linoleoyl-arachidonoyl-glycerol (βM 0.108 0.006, 0.210], 0.004) Cholesterol 0.238 0.002, 0.474], 0.048) identified mediators, which evidence Keloid through these mediators. The study presented credible fibrosis, potentially acting mediator association. These findings offer new insights into early screening prevention

Язык: Английский

An atlas on risk factors for gastrointestinal cancers: A systematic review of Mendelian randomization studies

Preventive Medicine, Год журнала: 2024, Номер 189, С. 108147 - 108147

Опубликована: Окт. 3, 2024

Язык: Английский

Exploring the Association Between Atopic Dermatitis and Malignancy

Dermatologic Clinics, Год журнала: 2024, Номер 42(4), С. 625 - 634

Опубликована: Сен. 13, 2024

Язык: Английский