Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(18)
Опубликована: Фев. 29, 2024
Abstract
The
rapid
assembly
of
valuable
cyclic
amine
architectures
in
a
single
step
from
simple
precursors
has
been
recognized
as
an
ideal
platform
term
efficiency
and
sustainability.
Although
vast
number
studies
regarding
synthesis
reported,
new
synthetic
disconnection
approaches
are
still
high
demand.
Herein,
we
report
catalytic
radical‐polar
crossover
cycloaddition
to
triggered
primary
sulfonamide
under
photoredox
condition.
This
newly
developed
disconnection,
comparable
established
approaches,
will
allow
construct
β,
β‐disubstituted
β‐monosubstituted
derivatives
efficiently.
study
highlights
the
unique
utility
bifunctional
reagent,
which
acts
radical
precursor
nucleophile.
open‐shell
methodology
demonstrates
broad
tolerance
various
functional
groups,
drug
natural
products
economically
sustainable
fashion.
Beilstein Journal of Organic Chemistry,
Год журнала:
2023,
Номер
19, С. 1055 - 1145
Опубликована: Июль 28, 2023
Photoredox
catalysis
(PRC)
is
a
cutting-edge
frontier
for
single
electron-transfer
(SET)
reactions,
enabling
the
generation
of
reactive
intermediates
both
oxidative
and
reductive
processes
via
photon
activation
catalyst.
Although
this
represents
significant
step
towards
chemoselective
and,
more
generally,
sustainable
chemistry,
its
efficacy
limited
by
energy
visible
light
photons.
Nowadays,
excellent
alternative
conditions
are
available
to
overcome
these
limitations,
harvesting
two
different
but
correlated
concepts:
use
multi-photon
such
as
consecutive
photoinduced
electron
transfer
(conPET)
combination
photo-
electrochemistry
in
synthetic
photoelectrochemistry
(PEC).
Herein,
we
review
most
recent
contributions
fields
activations
organic
functional
groups.
New
opportunities
chemists
captured,
selective
reactions
employing
super-oxidants
super-reductants
engage
unactivated
chemical
feedstocks,
scalability
up
gram
scales
continuous
flow.
This
provides
comparisons
between
techniques
(multi-photon
photoredox
PEC)
help
reader
fully
understand
their
similarities,
differences
potential
applications
therefore
choose
which
method
appropriate
given
reaction,
scale
purpose
project.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
11(3), С. 895 - 915
Опубликована: Дек. 20, 2023
Photoinduced
radical–polar
crossover
cyclization
(RPCC)
of
bifunctional
alkenes
is
high
synthetic
utility
to
produce
cyclic
products
with
precise
alkene
design.
This
review
summarizes
the
recent
representative
advances
in
field
RPC.
Organic Letters,
Год журнала:
2024,
Номер
26(12), С. 2511 - 2516
Опубликована: Март 20, 2024
This
work
demonstrates
the
synthesis
of
a
variety
perfluoroalkyl
heterocycles
via
visible-light-driven
radical-polar
crossover
cyclization
strategy.
In
this
process,
single-electron
reduction/SNV-type/cyclization
sequences
follow
radical
addition
reaction
diazoester,
which
differs
from
current
role
diazoesters
as
precursors/acceptors.
transformation
excellent
functional
group
compatibility
and
allows
for
modification
many
bioactive
molecules
with
diazoesters.
Such
could
represent
novel
approach
to
photochemical
diazo
compounds.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(18)
Опубликована: Фев. 29, 2024
Abstract
The
rapid
assembly
of
valuable
cyclic
amine
architectures
in
a
single
step
from
simple
precursors
has
been
recognized
as
an
ideal
platform
term
efficiency
and
sustainability.
Although
vast
number
studies
regarding
synthesis
reported,
new
synthetic
disconnection
approaches
are
still
high
demand.
Herein,
we
report
catalytic
radical‐polar
crossover
cycloaddition
to
triggered
primary
sulfonamide
under
photoredox
condition.
This
newly
developed
disconnection,
comparable
established
approaches,
will
allow
construct
β,
β‐disubstituted
β‐monosubstituted
derivatives
efficiently.
study
highlights
the
unique
utility
bifunctional
reagent,
which
acts
radical
precursor
nucleophile.
open‐shell
methodology
demonstrates
broad
tolerance
various
functional
groups,
drug
natural
products
economically
sustainable
fashion.
