Advances in understanding the effects of cardiopulmonary bypass on gut microbiota during cardiac surgery

The International Journal of Artificial Organs, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Cardiopulmonary bypass (CPB) is an indispensable technique in cardiac surgery; however, its impact on gut microbiota and metabolites remains insufficiently studied. CPB may disrupt the intestinal mucosal barrier, altering composition function of microbiota, thereby triggering local immune responses systemic inflammation, which lead to postoperative complications. This narrative review examines relevant literature from PubMed, Web Science, Google Scholar, CNKI databases over past decade. Keywords such as “gut microbiota,” “cardiopulmonary bypass,” “cardiac surgery,” “postoperative complications” were employed, with Boolean operators used refine search results. The changes before after CPB, their role complications, potential strategies for modulation improve outcomes.

Язык: Английский

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Rebuttal to Gut Microbiome in Children with Congenital Heart Disease After Cardiopulmonary Bypass Surgery (GuMiBear Study)

Pediatric Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Язык: Английский

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From heart to gut: Exploring the gut microbiome in congenital heart disease

iMeta, Год журнала: 2023, Номер 2(4)

Опубликована: Окт. 30, 2023

Abstract Congenital heart disease (CHD) is a prevalent birth defect and significant contributor to childhood mortality. The major characteristics of CHD include cardiovascular malformations hemodynamical disorders. However, the impact extends beyond circulatory system. Evidence has identified dysbiosis gut microbiome in patients with CHD. Chronic hypoxia inflammation associated affect microbiome, leading alterations its number, abundance, composition. aside from providing essential nutrients, engages direct interactions host immune system indirect via metabolites. abnormal or products can translocate into bloodstream through an impaired barrier, inflammatory state. Metabolites such as short‐chain fatty acids trimethylamine N ‐oxide, also play important roles development, treatment, prognosis This review discusses role immunity, neurodevelopment, perioperative period By fostering better understanding cross‐talk between this aims contribute improve clinical management outcomes for patients.

Язык: Английский

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Potential Impact of a Pregnant Woman’s Microbiota on the Development of Fetal Heart Defects: A Review of the Literature

Biomedicines, Год журнала: 2024, Номер 12(3), С. 654 - 654

Опубликована: Март 14, 2024

Developments in medicine and biology recent decades have led to a significant increase our knowledge of the complex interactions between microbiota human health. In context perinatal neonatology, particular attention is being paid potential impact maternal on fetal development. Among many aspects this relationship, question dysbiosis development heart defects an important one. article, we present analysis research scientific evidence relationship pregnant woman’s defects. We also discuss intervention strategies, including role probiotics diet optimising microbiota.

Язык: Английский

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Protective effect of the branched short‐chain fatty acid isobutyrate on intestinal damage in weaned piglets through intestinal microbiota remodeling

Journal of the Science of Food and Agriculture, Год журнала: 2024, Номер 105(3), С. 1556 - 1568

Опубликована: Окт. 16, 2024

Abstract BACKGROUND Postweaning intestinal damage in piglets is a challenging issue the livestock industry. Short‐chain fatty acids (SCFAs) are important metabolic products of gut microbiota and widely recognized for their role maintaining normal colonic function regulating immune system. However, effects branched short‐chain acid (BSCFA) isobutyrate on health remain largely unknown. This study aims to explore potential alleviating postweaning damage. RESULTS indicates that can alleviate diarrhea weaned piglets, enhance growth performance, optimize microbiota. mainly achieved through increasing relative abundance probiotic bacteria such as Lactobacillus , Megasphaera Prevotellaceae_UCG‐003 while concurrently reducing potentially harmful Clostridium_sensu_stricto‐1 Escherichia‐Shigella . It promotes production SCFAs, including acetate, isobutyrate, butyrate. Furthermore, it activates G‐protein‐coupled receptors (GPR43/109A), inhibits TLR4/MyD88 signaling pathway, strengthens barrier function, regulates expression related cytokines. CONCLUSION In summary, exogenous be considered promising feed additive improving piglets. © 2024 Society Chemical Industry.

Язык: Английский

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Effects of different hypoxia exposure on myeloid-derived suppressor cells in mice

Experimental and Molecular Pathology, Год журнала: 2024, Номер 140, С. 104932 - 104932

Опубликована: Сен. 20, 2024

Язык: Английский

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Response to “Gut Microbiome in Children with Congenital Heart Disease after Cardiopulmonary Bypass Surgery (GuMiBear Study)”

Pediatric Cardiology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 6, 2024

Язык: Английский

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Effect of preconception antibiotics exposure on female reproductive health and pregnancy outcomes: a systematic review and meta-analysis

EClinicalMedicine, Год журнала: 2024, Номер 78, С. 102935 - 102935

Опубликована: Ноя. 22, 2024

Язык: Английский

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The gut–heart axis: a review of gut microbiota, dysbiosis, and cardiovascular disease development

Annals of Medicine and Surgery, Год журнала: 2024, Номер 87(1), С. 177 - 191

Опубликована: Дек. 20, 2024

Язык: Английский

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