Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway

iMeta, Год журнала: 2024, Номер 3(1)

Опубликована: Янв. 15, 2024

Abstract Consumption of dietary fiber and anthocyanin has been linked to a lower incidence colorectal cancer (CRC). This study scrutinizes the potential antitumorigenic attributes black rice diet (BRD), abundantly rich in anthocyanin. Our results demonstrate notable effects mice on BRD, indicated by reduction both size number intestinal tumors consequent extension life span, compared control diet‐fed counterparts. Furthermore, fecal transplants from BRD‐fed germ‐free led decrease colonic cell proliferation, coupled with maintained integrity barrier. The BRD was associated significant shifts gut microbiota composition, specifically an augmentation probiotic strains Bacteroides uniformis Lactobacillus . Noteworthy changes metabolites were also documented, including upregulation indole‐3‐lactic acid indole. These have identified stimulate aryl hydrocarbon receptor pathway, inhibiting CRC proliferation tumorigenesis. In summary, these findings propose that may modulate progression fostering protective metabolite profiles. accentuates health advantages whole‐grain foods, emphasizing utility promoting health.

Язык: Английский

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The role of microbial indole metabolites in tumor

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Окт. 1, 2024

The gut microbiota can produce a variety of microbial-derived metabolites to influence tumor development. Tryptophan, an essential amino acid in the human body, be converted by microorganisms via indole pathway such as Indole-3-Lactic Acid (ILA), Indole-3-Propionic (IPA), Indole Acetic (IAA) and Indole-3-Aldehyde (IAld). Recent studies have shown that play key roles progression, they used adjuvant regimens for immunotherapy or chemotherapy. Here, we summarize recent findings on common microbial provide review mechanisms different microenvironment. We further discuss limitations current metabolite research future possibilities. It is expected will new strategies clinical therapy.

Язык: Английский

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The interplay between gut bacteria and targeted therapies: implications for future cancer treatments

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Фев. 13, 2025

Язык: Английский

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MetOrigin 2.0: Advancing the discovery of microbial metabolites and their origins

iMeta, Год журнала: 2024, Номер 3(6)

Опубликована: Ноя. 6, 2024

First introduced in 2021, MetOrigin has quickly established itself as a powerful web server to distinguish microbial metabolites and identify the bacteria responsible for specific metabolic processes. Building on growing understanding of interplay between microbiome metabolome, response user feedback, undergone significant upgrade version 2.0. This enhanced incorporates three new modules: (1) Quick search module that facilitates rapid identification associated with particular metabolite; (2) Orthology analysis links enzyme genes their corresponding bacteria; (3) Mediation investigates potential causal relationships among bacteria, metabolites, phenotypes, highlighting mediating role metabolites. Additionally, backend database been updated latest data from seven public databases (KEGG, HMDB, BIGG, ChEBI, FoodDB, Drugbank, T3DB), expanded coverage 210,732 each linked its source organism. 2.0 is freely accessible at http://metorigin.met-bioinformatics.cn.

Язык: Английский

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A comprehensive review on the potential health effects of anthocyanins in modulating autoimmune disease

Food Bioscience, Год журнала: 2025, Номер 66, С. 106245 - 106245

Опубликована: Фев. 26, 2025

Язык: Английский

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Parabacteroides johnsonii Inhibits the Onset and Progression of Colorectal Cancer by Modulating the Gut Microbiota

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Background Colorectal cancer (CRC) is the third most prevalent malignant tumor and second leading cause of cancer-related deaths globally. The genus Parabacteroides an important component gut microbiota. P. distasonis goldsteinii are reported probiotics, their roles in CRC have been investigated related studies. However, association between johnsonii remains unknown. Methods (10–42) Lactococcus formosensis (22–2) were isolated from healthy human feces. 25 mice that demonstrated normal feeding activity randomly assigned to four groups : control (NC group), model (IC (PJ L. (LO group). Colonic tissues IC, PJ, LO colon NC group then collected for HE staining immunohistochemical staining. Fecal samples during hyperproliferative adenoma phases Metagenomic sequencing metabolite analysis. Results intervention reduced number slowed growth colonic tumors, improved histological scores, decreased microenvironmental inflammation levels. composition intestinal flora with cancer, increased microbial species diversity, maintained microbiota stability. Furthermore, abundance Bifidobacterium pseudolongum Lactobacillus, which play a role ameliorating AOM/DSS-induced dysbiosis. affected metabolic pathways, including amino sugar degradation galactose metabolism, sphingolipid synthesis, acid polyphenol synthesis tryptophan metabolism pathway as primary being affected. Conclusion Our study profiled administration reduces tumors lower staging by modulating its metabolites at early stages.

Язык: Английский

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Bioactive compounds in colored Rice: Exploring natural agents for Cancer prevention in vitro and rodent model studies

Journal of Functional Foods, Год журнала: 2025, Номер 129, С. 106875 - 106875

Опубликована: Май 8, 2025

Язык: Английский

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Therapeutic Mechanism of Kynurenine, a Metabolite of Probiotics, on Atopic Dermatitis in Mice

Foods, Год журнала: 2025, Номер 14(10), С. 1816 - 1816

Опубликована: Май 20, 2025

Atopic Dermatitis (AD) is a common inflammatory skin disease characterized primarily by its chronic and recurrent nature. This has significant impact on productivity human longevity. Dysbiosis of gut flora been demonstrated to be significantly associated with the progression AD. In our previous research, it was shown that Lactobacillus rhamnosus RL5-H3-005 (RL) Pediococcus acidilactici RP-H3-006 (RP) have ability reduce risk in AD mice through gut–mammary axis. Based work, this study aims further investigate effects kynurenine (KYN), metabolite RL RP, induced 2, 4-dinitrofluorobenzene (DNFB). study, we found supplementing KYN effectively alleviates pathological symptoms atopic dermatitis improves levels SCFAs their intestines. Further research indicates KYN’s therapeutic are manifested reduction secretory immunoglobulin A (sIgA), E (IgE), interleukin-4 (IL-4), IL-5, IL-13, thymic stromal lymphopoietin (TSLP) mice, while also repairing intestinal barrier function mice. Overall, metabolites probiotics RP can regulate potentially improving gut–skin

Язык: Английский

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Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Май 23, 2025

Research indicates that abnormal gut microbiota metabolism is linked to colorectal cancer (CRC) progression, but the role of microbiota-related tryptophan disruption remains unclear. Using metagenomic sequencing and targeted Trp metabolomics, our research identified CRC patients had indole-3-lactic acid (ILA) levels, which were related tumor malignancy. Exogenous ILA administration suppressed development in AOM/DSS induced xenograft mice models. Furthermore, vitro experiments demonstrated inhibits cell proliferation, migration, anti-apoptotic capabilities. Mechanistically, appears directly occupy phosphorylation sites STAT3, leading a reduction intracellular phosphorylated STAT3 (p-STAT3) levels inhibition HK2 pathway, thereby downregulating glucose cells. Notably, this independent aryl hydrocarbon receptor (AHR). In conclusion, findings demonstrate alterations among can influence progression reveal novel mechanism through exerts its inhibitory effects on CRC. These offer new insights into identify potential clinical therapeutic targets.

Язык: Английский

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Intermittent fasting inhibits the development of colorectal cancer in APCMin/+ mice through gut microbiota and its related metabolites

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Май 29, 2025

Background and objectives Intermittent fasting is an emerging dietary approach, but its specific role in colorectal cancer (CRC) not yet clear. In this study, we investigated the relationship between intermittent development mice. Methods First, APC Min /+ mouse models (a spontaneous model of cancer) were subjected to intervention (2 days/week) with regular monitoring body weight changes. Subsequently, 16S rRNA sequencing untargeted metabolomics employed analyze alterations fecal microbial community structure metabolic profiles following intervention. Tumor was quantitatively assessed by enumerating CRC lesions using HE staining, while histopathological evaluation performed determine degree neoplastic progression. Concurrently, western blotting conducted examine expression levels intestinal barrier function-related proteins. Finally, vitro validation experiments, including colony formation assay transwell invasion assay, investigate effects key metabolite isovaleric acid on proliferative invasive capacities cells. Results significantly reduced tumor incidence approximately 50% compared control group (1.25 ± 0.38 vs 2.50 tumors/mouse, P = 0.017) markedly attenuated analysis revealed significant enrichment two bacterial genera, Alistipes (P 0.030) Odoribacter ( 0.030), along a reduction < 0.05) group. Furthermore, effectively controlled gain improved function 0.05). experiments further demonstrated that directly promoted cell proliferation enhanced their capacity Conclusion suppresses mice through gut microbiota related metabolites.

Язык: Английский

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