Advances in Engineered Phages for Disease Treatment

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Abstract Phage therapy presents a promising solution for combating multidrug‐resistant (MDR) bacterial infections and other bacteria‐related diseases, attributed to their innate ability target lyse bacteria. Recent clinical successes, particularly in treating MDR‐related respiratory post‐surgical infections, validated the therapeutic potential of phage therapy. However, complex microenvironment within human body poses significant challenges activity efficacy vivo. To overcome these barriers, recent advances engineering have aimed enhance targeting accuracy, improve stability survivability, explore synergistic combinations with modalities. This review provides comprehensive overview therapy, emphasizing application engineered phages antibacterial tumor vaccine development. Furthermore, highlights current future trends advancing toward broader applications.

Язык: Английский

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Novel Therapeutic Strategies and Recent Advances in Gut Microbiota Synergy with Nanotechnology for Colorectal Cancer Treatment

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101601 - 101601

Опубликована: Фев. 20, 2025

Over the last two decades, molecular biology advances have revealed gut microbiota's active and crucial role in colorectal cancer (CRC) pathogenesis its dysregulation during tumorigenesis. This understanding has underscored urgency of exploring novel therapeutic approaches to address challenges posed by CRC. Among these approaches, nanosynergistic therapies, with their potential modulate microbiota, increase drug bioavailability stability, reduce side effects, emerged as a promising avenue. Furthermore, efficacy nanotechnology-based can be enhanced combining them different methods, including chemotherapy, radiotherapy, immunotherapy, photothermal therapy, sonodynamic therapy. Herein, recent progress nano synergistic therapy been reviewed, focusing on synergy between microbiota nanotechnology CRC treatment. Additionally, diverse applications nanoparticles analyzed provide innovative ideas effective solutions for developing highly treatment strategies.

Язык: Английский

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Harnessing Nanoparticle Technology for Precision Medicine in Head and Neck Cancer: Targeted Delivery, Immunomodulation, and Clinical Translation

Nano TransMed, Год журнала: 2025, Номер 4, С. 100075 - 100075

Опубликована: Фев. 21, 2025

Язык: Английский

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A metal-drug self-delivery nanomedicine alleviates tumor immunosuppression to potentiate synergistic chemo/chemodynamic therapy against hepatocellular carcinoma

Fundamental Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

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Dietary influence on cancer progression: Gut health and genomic profiles

Current Problems in Cancer, Год журнала: 2024, Номер 54, С. 101159 - 101159

Опубликована: Ноя. 29, 2024

Язык: Английский

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