Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations DOI Creative Commons

Zijiao Liu,

Jun Zhang, Jiang Fei

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(4)

Опубликована: Апрель 1, 2025

ABSTRACT Backgrounds Dementia can impose a heavy economic burden on both society and families. Alzheimer's disease (AD), the most prevalent form of dementia, is complex neurodegenerative characterized by abnormal deposition extracellular amyloid β‐protein (Aβ) aggregation intracellular Tau protein to neurofibrillary tangles (NFTs). Given limited efficacy pharmacological treatment, scientists have already paid more attention non‐pharmacological strategies, including dietary restriction (DR). DR refers nutritional paradigm aimed at promoting overall health modifying balance between energy consumption expenditure. Studies demonstrated that effectively extends healthy lifespan, delays aging process, achieves promising results in prevention treatment AD preclinical studies. Methods In this review we collected related studies viewpoints searching PubMed database using keywords. Most citations were published 2015 2025. A few older literatures also included due their relevance significance field. Results We first provide concise overview current therapeutic preventive strategies for AD. Then, introduce several specific protocols favorable effects Furthermore, potential mechanisms underlying benefits are discussed. Finally, briefly highlight role maintaining brain health. Conclusion This may offer valuable insights into development innovative treatment.

Язык: Английский

Biological Effects of Dietary Restriction on Alzheimer's Disease: Experimental and Clinical Investigations DOI Creative Commons

Zijiao Liu,

Jun Zhang, Jiang Fei

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(4)

Опубликована: Апрель 1, 2025

ABSTRACT Backgrounds Dementia can impose a heavy economic burden on both society and families. Alzheimer's disease (AD), the most prevalent form of dementia, is complex neurodegenerative characterized by abnormal deposition extracellular amyloid β‐protein (Aβ) aggregation intracellular Tau protein to neurofibrillary tangles (NFTs). Given limited efficacy pharmacological treatment, scientists have already paid more attention non‐pharmacological strategies, including dietary restriction (DR). DR refers nutritional paradigm aimed at promoting overall health modifying balance between energy consumption expenditure. Studies demonstrated that effectively extends healthy lifespan, delays aging process, achieves promising results in prevention treatment AD preclinical studies. Methods In this review we collected related studies viewpoints searching PubMed database using keywords. Most citations were published 2015 2025. A few older literatures also included due their relevance significance field. Results We first provide concise overview current therapeutic preventive strategies for AD. Then, introduce several specific protocols favorable effects Furthermore, potential mechanisms underlying benefits are discussed. Finally, briefly highlight role maintaining brain health. Conclusion This may offer valuable insights into development innovative treatment.

Язык: Английский

Процитировано

0