ACS Materials Letters,
Год журнала:
2024,
Номер
7(1), С. 1 - 23
Опубликована: Ноя. 21, 2024
With
the
continuous
increase
in
average
life
expectancy,
population
aging
has
become
a
significant
health
issue
21st
century.
The
rising
prevalence
of
age-related
diseases
brought
tremendous
pressure
on
social
medical
systems
and
economy.
Against
this
backdrop,
research
anticellular
hot
spot
field
biomedicine,
biomaterials
are
showing
new
trends
potential
area.
Compared
to
drugs
other
traditional
anti-aging
strategies,
can
be
personalized
target
characteristics
different
tissues,
serving
as
drug
delivery
carriers
enhance
targeting,
directly
influence
cellular
process
by
modulating
microenvironment.
Furthermore,
offer
innovative
approaches
diagnosing
building
sophisticated
models,
which
our
understanding
biology
behind
speed
up
advancement
novel
treatments.
This
review
synthesizes
latest
advancements
biomaterial
for
combating
aging,
exploring
future
prospects
challenges.
Journal of Orthopaedic Translation,
Год журнала:
2025,
Номер
50, С. 111 - 128
Опубликована: Янв. 1, 2025
The
treatment
of
orthopaedic
diseases,
such
as
fractures
and
osteoarthritis,
remains
a
significant
challenge
due
to
the
complex
requirements
for
mechanical
strength
tissue
repair.
Hydrogels
based
on
hyaluronic
acid
methacrylate
(HAMA)
show
promise
engineering
materials
these
conditions.
Hyaluronic
(HA)
is
natural
component
extracellular
matrix,
known
its
good
compatibility.
HAMA-based
hydrogels
can
be
adjusted
through
crosslinking
by
combining
them
with
other
materials.
This
review
provides
an
overview
recent
research
applications
in
diseases.
First,
we
summarize
techniques
preparation
characterization
HAMA
hydrogels.
Next,
offer
detailed
use
treating
conditions
cartilage
injuries,
bone
defects,
meniscus
injuries.
Additionally,
discuss
diseases
related
orthopaedics.
Finally,
point
out
challenges
propose
future
directions
clinical
translation
strong
translational
potential
orthopaedics
their
biocompatibility,
adjustable
properties,
regenerative
capabilities.
With
ongoing
research,
are
well-positioned
applications,
particularly
repair,
osteoarthritis
treatment.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 161 - 179
Опубликована: Янв. 1, 2025
Background:
It
is
well
established
that
the
interaction
between
osteogenesis
and
inflammation
can
impact
bone
tissue
regeneration.
The
use
of
nanoparticles
to
treat
alleviate
at
molecular
level
has
potential
improve
osteogenic
microenvironment
serve
as
a
therapeutic
approach.
Methods:
We
have
synthesized
new
hollow
cerium
oxide
doped
with
cathepsin
B
inhibitor
(CA-074Me)
create
novel
h
CeO
2
@CA-074Me
NPs.
characterized
surface
morphology
physicochemical
properties
Macrophage
RAW
264.7
was
cultured
NPs
using
P.
gingivalis-
LPS
(
P.g
-LPS)
stimulation
model
inflammation.
RT-PCR
Western
blot
analysis
employed
evaluate
effects
on
macrophage
phenotype
CTSB-NLRP3
signaling
pathway.
To
further
investigate
inflammatory
microenvironment,
MC3T3-E1
cells
were
-LPS
an
in
vitro
conditions
under
then
co-cultured
for
7,
14,
21
d.
ability
evaluated
ALP
staining,
quantitative
analysis,
alizarin
red
analysis.
Results:
Findings
clearly
demonstrated
could
effectively
reduce
production
ROS
inhibited
signal
pathway,
thereby
significantly
attenuating
damage
caused
by
cellular
response.
also
induce
polarization
macrophages
towards
anti-inflammatory
M2
phenotype.
Additionally,
results
confirmed
inhibit
ameliorate
thus
promoting
cells.
Conclusion:
synthetic
able
modify
simultaneously
inhibiting
pathway
regulating
through
their
scavenge
ROS.
Based
these
findings,
our
study
may
offer
promising
approach
managing
damage.
Keywords:
nanoparticles,
CTSB,
NLRP3,
inflammation,
regeneration,
Abstract
Small
non‐coding
RNAs
(ncRNAs)
are
functional
molecules
contained
within
extracellular
vesicles
(EVs)
that
modulate
various
physiological
and
pathological
processes.
This
study
provides
a
comprehensive
expression
profile
of
seven
types
small
ncRNAs
in
serum‐
plasma‐derived
EVs
under
conditions.
Both
large
(lEVs)
(sEVs)
contain
high
proportions
miRNAs
(∼28.2%
lEVs
∼20.8%
sEVs)
ribosomal
(∼24.0%
∼19.1%
sEVs).
enriched
with
more
transfer
RNA
(∼38.8%)
than
sEVs,
whereas
sEVs
have
greater
abundance
Y
(∼22.5%).
Notably,
is
abundant
obtained
from
aged
samples
(age
≥60
years),
pattern
not
observed
lEVs.
diverse
serum‐derived
EVs.
There
also
degree
overlap
(>50%)
the
top
100
identified
sEVs.
The
hsa‐miR‐16‐5p,
hsa‐let‐7a‐5p,
hsa‐miR‐142‐3p,
hsa‐miR‐103‐3p
consistently
among
10
highly
expressed
plasma‐
as
well
peripheral
blood
mononuclear
cells.
Serum‐derived
glioblastoma,
breast
cancer,
prostate
gastric
cancer
specific,
miRNAs,
snoRNAs,
nuclear
RNAs,
piRNAs.
These
results
elucidate
patterns
ncRNA
cargoes
derived
serum
plasma
conditions
offer
valuable
insights
for
future
diagnostic
therapeutic
applications.
Abstract
The
field
of
extracellular
vesicle
(EV)
research
has
rapidly
evolved,
revealing
their
significant
roles
in
various
biological
processes
and
clinical
applications.
Allergic
diseases
are
prevalent
immunological
disorders
characterized
by
exaggerated
hypersensitivity
reactions
to
allergens,
leading
diverse
manifestations
that
can
severely
impact
quality
life.
Recently,
studies
have
underscored
the
pivotal
role
EVs
allergic
conditions,
including
asthma,
rhinitis,
atopic
dermatitis.
In
this
review,
we
provide
a
comprehensive
overview
recent
advances
separation
characterization
EVs,
diseases,
diagnostic
value
as
biomarkers.
Additionally,
explore
therapeutic
potential
for
treatment
prevention
conditions.
Overall,
emerging
insights
into
present
promising
opportunities
enhancing
diagnosis,
treatment,
management
diseases.
Abstract
Lubricin,
secreted
primarily
by
chondrocytes,
plays
a
critical
role
in
maintaining
the
function
of
cartilage
lubrication
system.
However,
both
external
factors
such
as
friction
and
internal
like
oxidative
stress
can
disrupt
this
system,
leading
to
osteoarthritis.
Inspired
lubricin,
lubricating
nanozyme,
that
is,
Poly‐2‐acrylamide‐2‐methylpropanesulfonic
acid
sodium
salt‐grafted
aminofullerene,
is
developed
restore
system
using
an
“In‐Out”
strategy.
The
“Out”
aspect
involves
reducing
through
combination
hydration
ball‐bearing
lubrication.
Simultaneously,
“In”
aims
mitigate
free
radical,
increasing
autophagy,
improving
mitochondrial
respiratory
chain.
This
results
reduced
chondrocyte
senescence
increased
lubricin
production,
enhancing
natural
ability
cartilage.
Transcriptome
sequencing
Western
blot
demonstrate
it
enhances
functionality
chain
complexes
I,
III,
V,
thereby
chondrocytes.
In
vitro
vivo
experiments
show
nanozymes
reduce
wear,
improve
senescence,
damage,
mitigating
progression
These
findings
provide
novel
insights
into
treating
diseases
associated
with
frictional
osteoarthritis,
set
stage
for
future
research
development
therapeutic
interventions.
Biomimetics,
Год журнала:
2024,
Номер
9(11), С. 656 - 656
Опубликована: Окт. 26, 2024
Ti
and
its
alloys,
widely
utilized
in
orthopedic
dental
implants,
inherently
lack
antibacterial
properties,
posing
significant
infection
risks,
especially
the
context
of
growing
antibiotic
resistance.
This
review
critically
evaluates
non-antibiotic
strategies,
with
a
particular
focus
on
surface
modifications
micro/nano-structured
surfaces.
Micro/nano-structured
surfaces,
inspired
by
natural
topographies,
utilize
physical
mechanisms
to
eradicate
bacteria.
Despite
their
potential,
efficacy
these
surfaces
remains
insufficient
for
clinical
application.
Titanium
dioxide
(TiO
European Journal of Orthopaedic Surgery & Traumatology,
Год журнала:
2025,
Номер
35(1)
Опубликована: Фев. 11, 2025
Abstract
Background
Elastic
modulus
is
an
important
biomechanical
component
that
indicates
stiffness
or
elasticity
of
biological
material.
Recently
the
use
digital
image
correlation
(DIC)
in
elastic
studies
on
fresh
tissue
has
shown
great
accuracy
estimating
properties;
thus,
aim
this
study
was
to
investigate
capsular
and
tendinous
layers
rotator
cuff
complex
employing
method.
Materials
methods
The
supraspinatus,
infraspinatus,
subscapularis
from
eight
(n
=
8)
fresh/frozen
shoulders
were
reverse
dissected
their
origins.
muscles
separated
one
another
produce
20
×
mm
strips
for
each
muscle.
DIC
employed
measure
strain
portions
during
tensile
testing,
tangent
values
obtained.
Results
yielded
higher
average
moduli
readings
(62.1
MPa,
67.1
59.6
respectively)
compared
counterparts
(29.0
32.5
41.5
respectively).
Conclusion
Different
findings
suggest
these
should
be
considered
independently
surgical
repair
avoid
imbalance
which
may
result
if
repaired
as
singular
layer.
