Combating Cellular Aging: Frontiers in Biomaterials and Therapies DOI
Senrui Liu, J. Q. Mou, Chen Zhao

и другие.

ACS Materials Letters, Год журнала: 2024, Номер 7(1), С. 1 - 23

Опубликована: Ноя. 21, 2024

With the continuous increase in average life expectancy, population aging has become a significant health issue 21st century. The rising prevalence of age-related diseases brought tremendous pressure on social medical systems and economy. Against this backdrop, research anticellular hot spot field biomedicine, biomaterials are showing new trends potential area. Compared to drugs other traditional anti-aging strategies, can be personalized target characteristics different tissues, serving as drug delivery carriers enhance targeting, directly influence cellular process by modulating microenvironment. Furthermore, offer innovative approaches diagnosing building sophisticated models, which our understanding biology behind speed up advancement novel treatments. This review synthesizes latest advancements biomaterial for combating aging, exploring future prospects challenges.

Язык: Английский

Harnessing the potential of hyaluronic acid methacrylate (HAMA) hydrogel for clinical applications in orthopaedic diseases DOI Creative Commons
Junliang Lu, Zongzhan Gao, Wei He

и другие.

Journal of Orthopaedic Translation, Год журнала: 2025, Номер 50, С. 111 - 128

Опубликована: Янв. 1, 2025

The treatment of orthopaedic diseases, such as fractures and osteoarthritis, remains a significant challenge due to the complex requirements for mechanical strength tissue repair. Hydrogels based on hyaluronic acid methacrylate (HAMA) show promise engineering materials these conditions. Hyaluronic (HA) is natural component extracellular matrix, known its good compatibility. HAMA-based hydrogels can be adjusted through crosslinking by combining them with other materials. This review provides an overview recent research applications in diseases. First, we summarize techniques preparation characterization HAMA hydrogels. Next, offer detailed use treating conditions cartilage injuries, bone defects, meniscus injuries. Additionally, discuss diseases related orthopaedics. Finally, point out challenges propose future directions clinical translation strong translational potential orthopaedics their biocompatibility, adjustable properties, regenerative capabilities. With ongoing research, are well-positioned applications, particularly repair, osteoarthritis treatment.

Язык: Английский

Процитировано

3

hCeO2@CA-074Me Nanoparticles Alleviate Inflammation and Improve Osteogenic Microenvironment by Regulating the CTSB-NLRP3 Signaling Pathway DOI Creative Commons

Zhaojun Niu,

Xiaomin Xia, Zhimin Zhang

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 161 - 179

Опубликована: Янв. 1, 2025

Background: It is well established that the interaction between osteogenesis and inflammation can impact bone tissue regeneration. The use of nanoparticles to treat alleviate at molecular level has potential improve osteogenic microenvironment serve as a therapeutic approach. Methods: We have synthesized new hollow cerium oxide doped with cathepsin B inhibitor (CA-074Me) create novel h CeO 2 @CA-074Me NPs. characterized surface morphology physicochemical properties Macrophage RAW 264.7 was cultured NPs using P. gingivalis- LPS ( P.g -LPS) stimulation model inflammation. RT-PCR Western blot analysis employed evaluate effects on macrophage phenotype CTSB-NLRP3 signaling pathway. To further investigate inflammatory microenvironment, MC3T3-E1 cells were -LPS an in vitro conditions under then co-cultured for 7, 14, 21 d. ability evaluated ALP staining, quantitative analysis, alizarin red analysis. Results: Findings clearly demonstrated could effectively reduce production ROS inhibited signal pathway, thereby significantly attenuating damage caused by cellular response. also induce polarization macrophages towards anti-inflammatory M2 phenotype. Additionally, results confirmed inhibit ameliorate thus promoting cells. Conclusion: synthetic able modify simultaneously inhibiting pathway regulating through their scavenge ROS. Based these findings, our study may offer promising approach managing damage. Keywords: nanoparticles, CTSB, NLRP3, inflammation, regeneration,

Язык: Английский

Процитировано

1

Comprehensive landscape of small non‐coding RNAs in large and small extracellular vesicles from human serum and plasma DOI Creative Commons
Gui‐Yan Xie, Yuxuan Deng, Chunjie Liu

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Abstract Small non‐coding RNAs (ncRNAs) are functional molecules contained within extracellular vesicles (EVs) that modulate various physiological and pathological processes. This study provides a comprehensive expression profile of seven types small ncRNAs in serum‐ plasma‐derived EVs under conditions. Both large (lEVs) (sEVs) contain high proportions miRNAs (∼28.2% lEVs ∼20.8% sEVs) ribosomal (∼24.0% ∼19.1% sEVs). enriched with more transfer RNA (∼38.8%) than sEVs, whereas sEVs have greater abundance Y (∼22.5%). Notably, is abundant obtained from aged samples (age ≥60 years), pattern not observed lEVs. diverse serum‐derived EVs. There also degree overlap (>50%) the top 100 identified sEVs. The hsa‐miR‐16‐5p, hsa‐let‐7a‐5p, hsa‐miR‐142‐3p, hsa‐miR‐103‐3p consistently among 10 highly expressed plasma‐ as well peripheral blood mononuclear cells. Serum‐derived glioblastoma, breast cancer, prostate gastric cancer specific, miRNAs, snoRNAs, nuclear RNAs, piRNAs. These results elucidate patterns ncRNA cargoes derived serum plasma conditions offer valuable insights for future diagnostic therapeutic applications.

Язык: Английский

Процитировано

1

Interplay between extracellular vesicles and allergic diseases: Current insights and future perspectives DOI Creative Commons
Jia Wu, Yan Wang, Yuqing Wang

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Abstract The field of extracellular vesicle (EV) research has rapidly evolved, revealing their significant roles in various biological processes and clinical applications. Allergic diseases are prevalent immunological disorders characterized by exaggerated hypersensitivity reactions to allergens, leading diverse manifestations that can severely impact quality life. Recently, studies have underscored the pivotal role EVs allergic conditions, including asthma, rhinitis, atopic dermatitis. In this review, we provide a comprehensive overview recent advances separation characterization EVs, diseases, diagnostic value as biomarkers. Additionally, explore therapeutic potential for treatment prevention conditions. Overall, emerging insights into present promising opportunities enhancing diagnosis, treatment, management diseases.

Язык: Английский

Процитировано

1

Application and progress of smart hydrogel microspheres for regulating oxidative stress in osteoarthritis DOI
Jinping Chen, Chengcheng Du, Bin Tang

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160620 - 160620

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Lubricin‐Inspired Nanozymes Reconstruct Cartilage Lubrication System with an “In‐Out” Strategy DOI
Chengcheng Du,

Zhuolin Chen,

Senrui Liu

и другие.

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Июль 4, 2024

Abstract Lubricin, secreted primarily by chondrocytes, plays a critical role in maintaining the function of cartilage lubrication system. However, both external factors such as friction and internal like oxidative stress can disrupt this system, leading to osteoarthritis. Inspired lubricin, lubricating nanozyme, that is, Poly‐2‐acrylamide‐2‐methylpropanesulfonic acid sodium salt‐grafted aminofullerene, is developed restore system using an “In‐Out” strategy. The “Out” aspect involves reducing through combination hydration ball‐bearing lubrication. Simultaneously, “In” aims mitigate free radical, increasing autophagy, improving mitochondrial respiratory chain. This results reduced chondrocyte senescence increased lubricin production, enhancing natural ability cartilage. Transcriptome sequencing Western blot demonstrate it enhances functionality chain complexes I, III, V, thereby chondrocytes. In vitro vivo experiments show nanozymes reduce wear, improve senescence, damage, mitigating progression These findings provide novel insights into treating diseases associated with frictional osteoarthritis, set stage for future research development therapeutic interventions.

Язык: Английский

Процитировано

4

Recent Advances in Antibacterial Strategies Based on TiO2 Biomimetic Micro/Nano-Structured Surfaces Fabricated Using the Hydrothermal Method DOI Creative Commons
Zilin Guo,

Hanpeng Liu,

Wuzhi Wang

и другие.

Biomimetics, Год журнала: 2024, Номер 9(11), С. 656 - 656

Опубликована: Окт. 26, 2024

Ti and its alloys, widely utilized in orthopedic dental implants, inherently lack antibacterial properties, posing significant infection risks, especially the context of growing antibiotic resistance. This review critically evaluates non-antibiotic strategies, with a particular focus on surface modifications micro/nano-structured surfaces. Micro/nano-structured surfaces, inspired by natural topographies, utilize physical mechanisms to eradicate bacteria. Despite their potential, efficacy these surfaces remains insufficient for clinical application. Titanium dioxide (TiO

Язык: Английский

Процитировано

4

Bioengineered bacterial extracellular vesicles for targeted delivery of an osteoclastogenesis-inhibitory peptide to alleviate osteoporosis DOI
Xiangxiang Kong, Han Liu,

Sumeng Chen

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113751 - 113751

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Revolutionizing tissue regeneration: the art of mimicking diverse collagen-based extracellular matrix hierarchies with decellularized tendon via bioskiving DOI
Na Bai,

Yamin Li,

Qiaobing Xu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 310, С. 143532 - 143532

Опубликована: Апрель 27, 2025

Язык: Английский

Процитировано

0

The elastic properties of the tendinous and capsular layers of the rotator cuff complex using fresh tissue—a biomechanical study DOI Creative Commons

Jessica Yvonne Cronjé,

Nkhensani Mogale, Shavana Govender

и другие.

European Journal of Orthopaedic Surgery & Traumatology, Год журнала: 2025, Номер 35(1)

Опубликована: Фев. 11, 2025

Abstract Background Elastic modulus is an important biomechanical component that indicates stiffness or elasticity of biological material. Recently the use digital image correlation (DIC) in elastic studies on fresh tissue has shown great accuracy estimating properties; thus, aim this study was to investigate capsular and tendinous layers rotator cuff complex employing method. Materials methods The supraspinatus, infraspinatus, subscapularis from eight (n = 8) fresh/frozen shoulders were reverse dissected their origins. muscles separated one another produce 20 × mm strips for each muscle. DIC employed measure strain portions during tensile testing, tangent values obtained. Results yielded higher average moduli readings (62.1 MPa, 67.1 59.6 respectively) compared counterparts (29.0 32.5 41.5 respectively). Conclusion Different findings suggest these should be considered independently surgical repair avoid imbalance which may result if repaired as singular layer.

Язык: Английский

Процитировано

0