Interface Allocation Precisely Customized Janus Upconversion Nanomotor for Atherosclerosis Amelioration
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 2, 2024
Abstract
Spatial
and
temporal
precisely
control
of
direction
speed
is
crucial
for
nanomotors
to
enable
complex
operations
applications
in
microsurgery,
drug
delivery,
isolation
biological
targets,
so
on.
Judicious
material
design
involving
Janus
nanoparticles
has
been
popular
over
the
past
decades,
however,
precise
customizable
modulation
structure
with
a
specific
asymmetric
ratio
motion
still
challenging.
In
this
study,
universal
“interface
allocation”
strategy
developed
efficient
controllable
preparation
mesoporous
silica‐coated
upconversion
(Janus
UCNP@mSiO
2
)
tuned
achieve
near‐infrared
(NIR)‐controlled
active
mobility
relieving
vessel
plaque.
Mesoporous
silica
thickness
50
nm
coated
onto
nanoparticles’
surface
an
optimal
coverage
50%
encapsulate
gas
propellant.
Upon
exposure
upconverted
blue
light,
release
nitric
oxide,
facilitating
their
pathologically
improving
atherosclerosis
through
endothelium‐dependent
vasodilation.
Experimental
theoretical
simulation
results
demonstrate
advantages
NIR‐controlled
treatment,
including
enhanced
nanoparticle‐transmittance
rate
(34.83%
85.57%)
excellent
vivo
therapeutic
efficacy.
Язык: Английский
Luminescence Fingerprint of Intracellular NIR-II Gold Nanocluster Transformation: Implications for Sensing and Imaging
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
Gold
nanoclusters
emitting
in
the
second
biological
window
(NIR-II-AuNCs)
have
gained
significant
interest
for
their
potential
deep-tissue
bioimaging
and
biosensing
applications
due
to
partial
transparency
reduced
autofluorescence
of
tissues
this
spectral
range.
However,
limited
understanding
how
environment
affects
luminescent
properties
might
hinder
use
biosensing.
In
study,
we
investigated
emission
NIR-II-AuNCs
when
interacting
internalizing
into
live
cells
including
macrophages,
fibroblasts,
cancer
cell
lines,
revealing
substantial
alterations
luminescence.
A
systematic
comparison
between
control
vitro
experiments
concluded
that
disruption
surface
ligands
is
main
factor
responsible
these
alterations.
within
cellular
environments
may
also
be
influenced
by
other
interactions,
aggregation
or
complexation
with
proteins.
Furthermore,
corroborated
spectroscopic
modifications
at
vivo
level,
providing
additional
evidence
environmental
sensitivity
NIR-II-AuNCs.
The
results
obtained
study
contribute
a
deeper
luminescence
mechanisms
living
are
crucial
optimization
as
reliable
tools
imaging
diagnostics.
Язык: Английский
Near-Infrared Nanothermometer Reveals Temperature Discrepancy between Organs and Body Surface for Heatstroke Prevention
Nano Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
Organ
temperatures
often
vary
significantly
from
body
surface
during
heatstroke,
leading
to
acute
organ
failure,
although
temperature
is
continuously
controlled.
However,
the
exact
discrepancy
between
them
remains
unclear
due
a
lack
of
noninvasive
techniques
for
real-time
monitoring
fluctuations.
Herein,
we
developed
near-infrared
emissive
nanothermometer
by
codoping
Nd3+
and
Yb3+
produce
two
distinct
emissions
at
980
1330
nm
under
808
excitation.
These
demonstrated
differential
responses
variations,
enabling
construction
ratiometric
nanoprobe
accurate
detection.
Notably,
rapidly
accumulated
in
mouse
liver
after
intravenous
injection,
revealing
that
showed
consistently
higher
than
rectum
approximately
1.5
°C.
Moreover,
injury
was
found
begin
rectal
42
°C,
rather
43
°C
conventionally
used
heatstroke
models.
findings
introduce
robust
accurately
understanding
pathological
progression
heat-related
illnesses.
Язык: Английский
Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers
Advanced NanoBiomed Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Lanthanide‐based
luminescence
nanothermometry
has
demonstrated
unprecedented
advantages
in
the
development
of
nanotheranostic
platforms
for
potential
medical
applications,
yet
despite
exponential
research
progress
and
great
enthusiasm
across
various
related
disciplines,
a
swift
bench‐to‐bedside
translation
seems
to
be
still
out
reach.
This
is
predominantly
fundamental
issues
at
preclinical
stage,
such
as
complex
nanomaterials
design,
incomplete
optimization,
fragmented
characterization,
insufficient
validation
nanothermometer
performance
physiological
environments.
The
main
impediments
currently
are
important
biophysicochemical
that
must
addressed
comprehensively,
first
foremost
available
vitro
systems,
before
going
on
vivo
investigations.
review
outlines
critical
perspective,
well
route
suggestions
underexplored
aspects
address
significantly
minimize
existing
translational
gap.
Язык: Английский
NIR-II upconversion nanomaterials for biomedical applications
Nanoscale,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
This
review
provides
a
comprehensive
overview
of
recent
biomedical
applications
upconversion
nanomaterials
specifically
within
the
near-infrared
two-region
(NIR-II)
window
(1000–1700
nm).
Язык: Английский
Combating Cellular Aging: Frontiers in Biomaterials and Therapies
ACS Materials Letters,
Год журнала:
2024,
Номер
7(1), С. 1 - 23
Опубликована: Ноя. 21, 2024
With
the
continuous
increase
in
average
life
expectancy,
population
aging
has
become
a
significant
health
issue
21st
century.
The
rising
prevalence
of
age-related
diseases
brought
tremendous
pressure
on
social
medical
systems
and
economy.
Against
this
backdrop,
research
anticellular
hot
spot
field
biomedicine,
biomaterials
are
showing
new
trends
potential
area.
Compared
to
drugs
other
traditional
anti-aging
strategies,
can
be
personalized
target
characteristics
different
tissues,
serving
as
drug
delivery
carriers
enhance
targeting,
directly
influence
cellular
process
by
modulating
microenvironment.
Furthermore,
offer
innovative
approaches
diagnosing
building
sophisticated
models,
which
our
understanding
biology
behind
speed
up
advancement
novel
treatments.
This
review
synthesizes
latest
advancements
biomaterial
for
combating
aging,
exploring
future
prospects
challenges.
Язык: Английский