Eriodictyol 5-O-methyl ether inhibits prostate cancer progression through targeting STAT3 signaling and inducing apoptosis and paraptosis

Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер 766, С. 110331 - 110331

Опубликована: Фев. 7, 2025

Язык: Английский

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Exploring paraptosis as a therapeutic approach in cancer treatment

Journal of Biomedical Science, Год журнала: 2024, Номер 31(1)

Опубликована: Ноя. 4, 2024

Abstract A variety of cell death pathways play critical roles in the onset and progression multiple diseases. Paraptosis, a unique form programmed death, has gained significant attention recent years. Unlike apoptosis necrosis, paraptosis is characterized by cytoplasmic vacuolization, swelling endoplasmic reticulum mitochondria, absence caspase activation. Numerous natural products, synthetic compounds, newly launched nanomedicines have been demonstrated to prime through paraptotic program may offer novel therapeutic strategies for cancer treatment. This review summarizes findings, delineates intricate network signaling underlying paraptosis, discusses potential implications targeting The aim this expand our understanding process explore

Язык: Английский

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Design, synthesis and biological evaluation of novel naphthoquinothiazole derivatives as potent antitumor agents through inhibiting STAT3

Bioorganic Chemistry, Год журнала: 2024, Номер 150, С. 107565 - 107565

Опубликована: Июнь 15, 2024

Язык: Английский

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Paraptosis—A Distinct Pathway to Cell Death

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11478 - 11478

Опубликована: Окт. 25, 2024

Cell death is a critical biological process necessary for development, tissue maintenance, and defense against diseases. To date, more than 20 forms of cell have been identified, each defined by unique molecular pathways. Understanding these different essential investigating the pathogenesis diseases such as cancer, neurodegenerative disorders, autoimmune conditions developing appropriate therapies. Paraptosis distinct form regulated characterized cytoplasmic vacuolation dilatation cellular organelles like mitochondria endoplasmic reticulum (ER). It several signaling pathways, instance, those associated with ER stress, calcium overload, oxidative specific cascades insulin-like growth factor I receptor (IGF-IR) its downstream pathways comprising mitogen-activated protein kinases (MAPKs) Jun N-terminal kinase (JNK). has observed in diverse contexts, including development stress responses neuronal, retinal, endothelial, muscle cells. The induction paraptosis increasingly important anticancer therapy, it targets non-apoptotic tumor cells, which can be utilized to induce death. This approach enhances treatment efficacy addresses drug resistance, particularly cases where cancer cells are resistant apoptosis. Combining paraptosis-inducing agents traditional therapies holds promise enhancing overcoming suggesting valuable strategy therapy.

Язык: Английский

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A Validated RP-HPLC–DAD Method for Analyzing Flavonoids in Caatinga Brazilian Green Propolis from Mimosa tenuiflora Produced by Apis mellifera

Revista Brasileira de Farmacognosia, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Язык: Английский

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TMP: A dual modulator of apoptosis and autophagy via SHP-1 regulation in hepatocellular carcinoma

Life Sciences, Год журнала: 2024, Номер unknown, С. 123316 - 123316

Опубликована: Дек. 1, 2024

Язык: Английский

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