Inhibition of the thioredoxin system for radiosensitization therapy of cancer

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 268, С. 116218 - 116218

Опубликована: Фев. 9, 2024

Язык: Английский

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Development and synthesis of diffractaic acid analogs as potent inhibitors of colorectal cancer stem cell traits

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 25, 2025

In recent years, evidence for the anti-cancer activity of lichen secondary metabolites has been rapidly increasing. this study, we synthesised analogues diffractaic acid, a metabolite, and evaluated their ability to suppress colorectal cancer stem potential. Among 10 compounds after H/CH₃/benzylation acid structure or modifications in an aromatic hydrophobic domain, TU3 more inhibition effect on potential compared other compounds. The compound targets ALDH1 suppresses key signalling pathways such as WNT, STAT3, NF-κB, Hedgehog, AP-1. Inhibition these by contribute attenuate survival mechanisms cell thus inhibit progression.

Язык: Английский

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Screening of Chemical Profile by LC–MS/MS and Assessment of Biological Properties of Achillea sintenisii Hub. Mor. From Turkey

Chemistry & Biodiversity, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

ABSTRACT The aim of this study was to determine the secondary metabolites n ‐hexane, ethyl acetate, methanol, and water extracts Achillea sintenisii Hub. Mor. ascertain their divergent biological properties. LC–MS/MS analysis performed identify bioactive compounds. anticancer properties samples were tested against human breast (MCF‐7 MDA‐MB‐453) colon (HT‐29) cancer cell lines by XTT assay. anti‐Alzheimer's studies using Ellman's antimicrobial carried out Kirby–Bauer disc diffusion method. antioxidative potential evaluated on basis 2,2‐diphenyl‐1‐picrylhydrazyl scavenging ferric reducing antioxidant power assays, revealed 27 phytochemicals, including high concentrations quinic acid, gentisic chlorogenic luteolin, cynaroside, caffeic acid. Ethyl acetate extract exhibited most potent cytoxicity MDA‐MB‐453 cells, with an IC 50 value 83.05 µg/mL. All showed stronger inhibitory activity acetylcholinesterase butyrylcholinesterase compared tacrine. methanol considerable Enterococcus faecalis , approaching level vancomycin. Methanol possessed highest DPPH power. These findings render A, a promising source for pharmaceutical, cosmetic, food industries.

Язык: Английский

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Diffractaic acid exerts anti-cancer effects on hepatocellular carcinoma HepG2 cells by inducing apoptosis and suppressing migration through targeting thioredoxin reductase 1

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(8), С. 5745 - 5755

Опубликована: Фев. 3, 2024

Hepatocellular carcinoma (HCC) represents one of the most common malignant tumors worldwide. Due to limited number available drugs and their side effects, development new chemotherapeutic strategies for HCC treatment has become increasingly important. This study is aimed at investigating whether diffractaic acid (DA), secondary metabolites lichen, exhibits a potential anticancer effect on HepG2 cells its mediated by inhibition thioredoxin reductase 1 (TRXR1), which target due overexpression in tumor including HCC. XTT assay results showed that DA exhibited strong cytotoxicity with an IC

Язык: Английский

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5-methyl-N'-(thiophen-2-ylmethylene)-1H-pyrazole-3-carbohydrazide as potent anticancer agent: Synthesis, spectroscopic characterization, anticancer activity and DFT studies

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 140919 - 140919

Опубликована: Ноя. 1, 2024

Язык: Английский

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Antiproliferative, antimigratory, and apoptotic effects of diffractaic and vulpinic acids as thioredoxin reductase 1 inhibitors on cervical cancer

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 397(3), С. 1525 - 1535

Опубликована: Сен. 1, 2023

Язык: Английский

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