International Journal of Heat and Mass Transfer, Год журнала: 2024, Номер 240, С. 126636 - 126636
Опубликована: Дек. 30, 2024
Язык: Английский
Nature Reviews Bioengineering, Год журнала: 2024, Номер unknown
Опубликована: Сен. 26, 2024
Язык: Английский
Процитировано
41
Theranostics, Год журнала: 2023, Номер 13(10), С. 3346 - 3367
Опубликована: Янв. 1, 2023
Hypoxia causes the expression of signaling molecules which regulate cell division, lead to angiogenesis, and further, in tumor microenvironment, promote resistance chemotherapy radiotherapy, induce metastasis. Photoacoustic imaging (PAI) takes advantage unique absorption characteristics chromophores tissues provides opportunity construct images with a high degree spatial temporal resolution. In this review, we discuss physiologic hypoxia, current applications PAI using endogenous (label free imaging) exogenous (organic inorganic) contrast agents. Features various methods terms their efficacy for determining proteomic phenomena are analyzed. This review demonstrates that has potential understand growth metastasis development through measurement regulatory molecule concentrations, oxygen gradients, vascular distribution.
Язык: Английский
Процитировано
35
Photoacoustics, Год журнала: 2023, Номер 32, С. 100538 - 100538
Опубликована: Июль 27, 2023
We have developed and optimized an imaging system to study improve the detection of brain hemorrhage quantify oxygenation. Since this is intended be used for in neonates through skull opening, i.e., fontanelle, we called it, Transfontanelle Photoacoustic Imaging (TFPAI) system. The terms optical acoustic designs, thermal safety, mechanical stability. lower limit quantification TFPAI detect location its size evaluated using in-vitro ex-vivo experiments. capability measuring tissue oxygenation vasogenic edema due blood barrier disruption are demonstrated. results obtained from our experimental evaluations strongly suggest potential utility TFPAI, as a portable modality neonatal intensive care unit. Confirmation these findings in-vivo could facilitate translation promising technology clinic.
Язык: Английский
Процитировано
18
Chemosensors, Год журнала: 2022, Номер 10(5), С. 181 - 181
Опубликована: Май 9, 2022
Acoustic biosensors are widely used in physical, chemical, and biosensing applications. One of the major concerns acoustic is delicacy medium through which waves propagate reach sensors. Even a small airgap diminishes signal strengths due to high impedance mismatch. Therefore, presence coupling create pathway for an efficient propagation essential. Here, we have reviewed characteristics various material (liquid, gel-based, semi-dry, dry) present guide determine suitable application-specific medium.
Язык: Английский
Процитировано
21
Bioengineering & Translational Medicine, Год журнала: 2022, Номер 8(2)
Опубликована: Сен. 29, 2022
Abstract Photoacoustic computed tomography (PACT) is a hybrid imaging modality that combines optical excitation and acoustic detection techniques. It obtains high‐resolution deep‐tissue images based on the deep penetration of light, anisotropy light absorption in objects, photoacoustic effect. Hence, PACT shows great potential biomedical sample imaging. Recently, due to its advantages high sensitivity wide scalability spatial resolution with desired depth, has received increasing attention preclinical clinical practice. To date, there been proliferation systems designed for specific applications, from small animals human organs, ex vivo real‐time imaging, simple structural functional molecular external contrast agents. Therefore, it importance summarize previous applications In this review, we searched studies related tissues samples over past two decades; divided into categories, organs body parts; discussed significance studies. Finally, pointed out future directions applications. With development exogenous agents advances technique, future, will enable whole bodies, superficial vasculature internal anatomy functions, play an increasingly important role research
Язык: Английский
Процитировано
18
Journal of Biophotonics, Год журнала: 2023, Номер 17(3)
Опубликована: Ноя. 28, 2023
Abstract Various reconstruction algorithms have been implemented for linear array photoacoustic imaging systems with the goal of accurately reconstructing strength absorbers within tissue being imaged. Since existing introduced by different research groups and context performance evaluation was not consistent, it is difficult to make a fair comparison between them. In this study, we systematically compared 10 published image (DAS, UBP, pDAS, DMAS, MV, EIGMV, SLSC, GSC, TR, FD) using in‐vitro phantom data. Evaluations were conducted based on lateral resolution reconstructed images, computational time, target detectability, noise sensitivity. We anticipate outcome study will assist researchers in selecting appropriate their PA applications.
Язык: Английский
Процитировано
9
Chinese Journal of Lasers, Год журнала: 2024, Номер 51(9), С. 0907005 - 0907005
Опубликована: Янв. 1, 2024
皮肤疾病是一种较为常见的人类疾病,其检测与诊断十分重要。传统的检测方法因医师主观影响和皮肤创伤问题不利于对皮肤病作出准确高效的判断,故皮肤成像技术逐渐被用于辅助诊断。光声成像技术作为一种新兴的成像方式,结合了光学成像的高对比度和超声成像的深穿透优势,逐渐被人们所关注。本文针对光声皮肤成像技术进行了回顾与总结,按照成像方式对光声皮肤成像系统进行了分类与归纳,从重构算法提升角度总结了现有的性能提升方法与策略。此外,按照皮肤病类别探讨了当前光声皮肤成像技术的临床应用,验证了光声皮肤成像技术的发展前景与潜力。最后针对现有方法的缺点与限制,对未来光声皮肤成像技术的发展方向和关键环节进行了设想与讨论。
Процитировано
3
Photoacoustics, Год журнала: 2025, Номер 43, С. 100701 - 100701
Опубликована: Фев. 23, 2025
Язык: Английский
Процитировано
0
Photonics, Год журнала: 2025, Номер 12(4), С. 385 - 385
Опубликована: Апрель 16, 2025
Typically, multi-single-element photoacoustic computed tomography (PACT) systems utilize numerous ultrasound transducers arranged in cylindrical or hemispherical configurations for detection, combined with a single diffuse light source multiple sparse sources to illuminate the imaging target. While these produce high-quality 3D PA images, they require complex, multi-channel data acquisition (DAQ) acquire from all transducers. These DAQ are often bulky and expensive, significantly limiting clinical translation of PACT patient care. In this study, we evaluated feasibility using compact cost-effective Texas Instruments analog front-end module systems. By simple phantom, demonstrated capability affordable board, reconstructed images showing promise practical economical solutions This advancement paves way broader applications both research settings.
Язык: Английский
Процитировано
0
Journal of Biophotonics, Год журнала: 2023, Номер 16(7)
Опубликована: Апрель 13, 2023
Brain hemorrhage, specifically intraventricular hemorrhage (IVH), is considered one of the primary and leading causes cerebral anomalies in neonates. Several imaging modalities including most popular, cranial ultrasound, are not capable detecting early stage IVHs. Photoacoustic (PAI) exhibited great potential for studies limited to small animal models, but these models comparable neonatal brain morphology. However, detection large using PAI rare due complexity cost inducing vivo. Moreover, vitro unable represent physiology environment hemorrhagic lesion. Here, we proposed a pseudo implementation method sheep that allows us mimic different lesions ex vivo without compromising imaging. This approach enables true evaluation performance hemorrhages can be utilized as reference optimize system
Язык: Английский
Процитировано
8