Reshaped functional connectivity gradients in acute ischemic stroke
NeuroImage Clinical,
Год журнала:
2025,
Номер
45, С. 103755 - 103755
Опубликована: Янв. 1, 2025
Язык: Английский
Reshaped functional connectivity gradients in acute ischemic stroke
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 25, 2024
ABSTRACT
Ischemic
brain
stroke
disrupts
blood
flow,
leading
to
functional
and
structural
changes
associated
with
behavioral
deficits.
Importantly,
despite
this
disruption
occurring
in
localized
regions,
the
resulting
organization
are
both
high-dimensional
widespread
across
human
cortex.
However,
mechanisms
which
these
global
patterns
emerge
subsequent
deficits
they
entail,
remain
largely
unexplored.
Functional
connectivity
gradients
provide
consistent,
reproducible,
robust
low-dimensional
representations
of
function
that
can
be
explored
reduce
heterogeneity
a
handful
axes
along
is
organized.
Here,
we
investigated
how
canonical
gradient
space
by
aligning
each
patient
control-averaged
embedding
computing
distances
“correct”
positions
quantify
deviations
their
contribution
explicitly
corrected
for
stroke-induced
hemodynamic
lags
further
study
contribution.
We
found
lag
correction
enhanced
most
prominently
second
gradient,
on
visual
somatomotor
concentrated.
Additionally,
identified
significant
primarily
within
somatomotor,
visual,
ventral
attention
networks,
correlating
impairments.
studied
hemispheric
asymmetries
finding
intact
hemispheres
preserve
comparable
asymmetry
while
damaged
ones
presented
important
changes.
Lastly,
right-sided
lesions
displayed
more
than
contralateral
lesions.
Overall,
evidence
1)
correcting
improves
accuracy,
as
indicated
increased
percentages
explained
variance,
2)
impairments
result
from
repositioning
region-based
profiles
low-dimensional,
interpretable
space.
This
suggests
large-scale
alterations
manifest
slight,
predictable
movements
confined
visual-somatomotor
axis.
Язык: Английский
Brain Functional Characteristics in Football Players During Motor‐Cognitive Dual Task: Insights From fNIRS
Scandinavian Journal of Medicine and Science in Sports,
Год журнала:
2024,
Номер
35(1)
Опубликована: Дек. 27, 2024
ABSTRACT
Long‐term
training
enables
professional
athletes
to
develop
concentrated
and
efficient
neural
network
organizations
for
specific
tasks.
This
study
used
functional
near‐infrared
spectroscopy
investigate
task
performance,
brain
characteristics,
their
relationships
in
footballers
during
sport‐specific
motor‐cognitive
processes.
Twenty‐four
(athlete
group,
with
18
remaining
of
good
signal
quality)
20
non‐footballers
(control
16
remaining)
completed
four
tasks:
a
single
(trigger
buttons
corresponding
the
appearance
direction
teammates
kicking
actions),
an
N‐back
task,
dual
digit
task.
Brain
activation,
connectivity
(FC),
lateralization
were
calculated,
correlation
behavioral
indicators
was
analyzed.
Results
showed
that
reaction
times
shorter
across
all
The
activation
value
right
dorsolateral
prefrontal
cortex
(DLPFC)
decreased
compared
resting
state
athlete
group.
values
regions
(except
left
primary
sensory
task),
DLPFC
(dual
premotor
&
supplementary
motor
area
(left
PMC
SMA,
task)
significantly
lower
group
than
control
Footballers
exhibited
higher
interhemispheric
FC
tasks,
greater
leftward
bias
between
(PFC)
‐left
SMA
within
PFC
region
positively
correlated
accuracy
better
performance
less
impact
from
load,
central
energy
consumption
sensory‐motor
execution,
indicating
more
state.
Enhancing
function
related
networks
may
improve
athletes'
reactive
abilities
performance.
Язык: Английский