Nanostructured Lipid Carriers: A Revolutionary Approach in Antifungal Drug Delivery

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Язык: Английский

Mechanisms and regulation of iron uptake and the role of iron in pathogenesis of Candida albicans

Critical Reviews in Microbiology, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Май 24, 2025

Candida albicans is a primary pathogen implicated in invasive fungal infections. Through its intricate iron uptake and regulatory systems, C. adeptly adapts to various iron-rich environments, circumventing the growth virulence restrictions imposed by host's nutritional immunity intensifying infection severity. This fungus activates Sef1-Sfu1-Hap43 homeostasis circuit via bioavailability sensors (iron-sulfur cluster assembly system). activation precisely regulates multiple pathways, including high-affinity reduction system, heme-iron pathway, siderophore as well genes involved utilization storage, thus ensuring effective acquisition maintaining across diverse environmental conditions developmental stages. Conversely, disruptions metabolism markedly diminish albicans's pathogenic potential impairing mitochondrial function, suppressing hyphal formation, limiting colonization, reversing antifungal drug resistance. review presents comprehensive analysis of mechanisms governing regulation examines consequences impaired on progression, Our goal provide theoretical framework better understand pathogenesis support development targeted therapeutic strategies against this resilient pathogen.

Язык: Английский

Utility of Itraconazole in Combination with Liposomal Amphotericin B in Rhizopus oryzae Associated Mucormycosis–An Exploratory Study

Mycopathologia, Год журнала: 2024, Номер 189(4)

Опубликована: Июнь 12, 2024

Язык: Английский