AKR1B1 Inhibits Ferroptosis and Promotes Gastric Cancer Progression via Interacting With STAT3 to Activate SLC7A11

Cell Biology International, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Gastric cancer (GC) is a frequently diagnosed malignant tumor in clinical settings; however, the mechanisms underlying its tumorigenesis remain inadequately understood. In this study, we identified significantly elevated expression levels of AKR1B1 GC tissues through quantitative polymerase chain reaction (qPCR) and western blotting assays. Furthermore, negative correlation was established between patient survival probability levels. Functionally, our experiments, including colony formation, transwell migration, xenograft assays, demonstrated that depletion inhibited proliferation progression cells both vivo vitro. Additionally, assessment reactive oxygen species (ROS), malondialdehyde (MDA), glutathione (GSH), mitochondrial morphology confirmed induces ferroptosis. Mechanistically, found interacts with STAT3, which subsequently activates SLC7A11. Notably, ferroptosis induced by could be reversed overexpression SLC7A11, thereby substantiating these interactions. conclusion, findings identify as novel oncogene elucidate mechanism involving AKR1B1-STAT3-SLC7A11 pathway ferroptosis, providing new insights for potential therapeutic strategies treatment GC.

Язык: Английский

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SORBS3-β suppresses lymph node metastasis in cervical cancer by promoting the ubiquitination of β-catenin

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 8, 2025

Язык: Английский

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Unraveling the Role of Ubiquitin-Conjugating Enzyme UBE2T in Tumorigenesis: A Comprehensive Review

Cells, Год журнала: 2024, Номер 14(1), С. 15 - 15

Опубликована: Дек. 26, 2024

Ubiquitin-conjugating enzyme E2 T (UBE2T) is a crucial in the ubiquitin-proteasome system (UPS), playing significant role ubiquitination of proteins and influencing wide range cellular processes, including proliferation, differentiation, apoptosis, invasion, metabolism. Its overexpression has been implicated various malignancies, such as lung adenocarcinoma, gastric cancer, pancreatic liver ovarian where it correlates strongly with disease progression. UBE2T facilitates tumorigenesis malignant behaviors by mediating essential functions DNA repair, cell cycle regulation, activation oncogenic signaling pathways. High levels expression are associated poor survival outcomes, highlighting its potential molecular biomarker for cancer prognosis. Increasing evidence suggests that acts an oncogene could serve promising therapeutic target treatment. This review aims to provide detailed overview UBE2T’s structure, functions, mechanisms involved progression well recent developments UBE2T-targeted inhibitors. Such insights may pave way novel strategies diagnosis treatment, enhancing our understanding biology supporting development innovative approaches.

Язык: Английский

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UBE2T promotes stage I lung adenocarcinoma progression through PBX1 ubiquitination and PBX1/RORA regulation

BMC Cancer, Год журнала: 2024, Номер 24(1)

Опубликована: Сен. 18, 2024

Язык: Английский

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Ubiquitin-conjugating enzyme E2T confers chemoresistance of colorectal cancer by enhancing the signal propagation of Wnt/β-catenin pathway in an ERK-dependent manner

Chemico-Biological Interactions, Год журнала: 2024, Номер 406, С. 111347 - 111347

Опубликована: Дек. 10, 2024

Язык: Английский

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