International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3368 - 3368

Опубликована: Апрель 4, 2025

Glioblastoma, the most common and aggressive primary malignant brain tumor, is characterized by a high rate of recurrence, disability, lethality. Therefore, there pressing need to develop more effective prognostic biomarkers treatment approaches for glioblastoma. Lactylation, an emerging form protein post-translational modification, has been closely associated with lactate, metabolite glycolysis. Since initial identification lactylation sites in core histones 2019, accumulating evidence shown critical role that plays glioblastoma development, assessment poor clinical prognosis, immunosuppression, which provides fresh angle investigating connection between metabolic reprogramming epigenetic plasticity cells. The objective this paper present overview roles expanding field research explore practical value developing novel plans combining targeted therapy immunotherapy.

Язык: Английский