Acute liver failure

The Lancet, Год журнала: 2024, Номер 404(10454), С. 789 - 802

Опубликована: Авг. 1, 2024

Язык: Английский

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Recommendations of the Experts of the Polish Cardiac Society (PCS) and the Polish Lipid Association (PoLA) on the diagnosis and management of elevated lipoprotein(a) levels

Archives of Medical Science, Год журнала: 2024, Номер 20(1), С. 8 - 27

Опубликована: Янв. 30, 2024

Lipoprotein(a) [Lp(a)] is made up of a low-density lipoprotein (LDL) particle and specific apolipoprotein(a). The blood concentration Lp(a) approximately 90% genetically determined, the main genetic factor determining levels size apo(a) isoform, which determined by number KIV2 domain repeats. isoform inversely proportional to Lp(a). strong independent cardiovascular risk factor. Elevated ≥ 50 mg/dl (≥ 125 nmol/l) are estimated occur in more than 1.5 billion people worldwide. However, determination performed far too rarely, including Poland, where, fact, it only since 2021 guidelines Polish Lipid Association (PoLA) five other scientific societies that measurements have begun be performed. Determination concentrations not easy due to, among things, different sizes isoforms; however, currently available certified tests make possible distinguish between with low high degree precision. In 2022, first for management patients elevated lipoprotein(a) were published European Atherosclerosis Society (EAS) American Heart (AHA). result work experts from two their aim provide clear, practical recommendations levels.

Язык: Английский

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Influence of therapeutic plasma exchange treatment on short-term mortality of critically ill adult patients with sepsis-induced organ dysfunction: a systematic review and meta-analysis

Critical Care, Год журнала: 2024, Номер 28(1)

Опубликована: Янв. 4, 2024

Abstract Introduction The impact of therapeutic plasma exchange (TPE) on short-term mortality in adult patients with sepsis-induced organ dysfunction remains uncertain. objective the study is to assess effect adjunct TPE this setting through a comprehensive literature review. Methods National Library Medicine’s Medline, Ovid (Embase), Cochrane database and clinicaltrial.gov from January 01, 1966, until October 2022, were searched for terms: exchange, plasmapheresis, sepsis, septic shock. We reviewed, selected extracted data relevant randomized clinical trials (RCTs) matched cohort studies (MCSs) comparing critically ill treated standard therapy versus those receiving TPE. Risk bias was assessed RCTs using Collaboration tool MCSs ROBINS-I tool. Summary statistics, risk ratios (RRs), confidence intervals (CIs) calculated random effects model. Results This systematic review included 937 five (n = 367) fifteen 570). Of these total, 543 received treatment addition care. meta-analysis includes all only six 627). 300) showed significant reduction (RR 0.59, 95% CI 0.47–0.74, I2 3%) compared alone 327). 20 revealed that adding resulted faster and/or laboratory recovery. Conclusions Our up-to-date demonstrates may provide potential survival benefits when care dysfunction. While results are encouraging, large well-designed required identify optimal patient population procedure characteristics prior widespread adoption into practice.

Язык: Английский

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Use of Intravenous Albumin

CHEST Journal, Год журнала: 2024, Номер 166(2), С. 321 - 338

Опубликована: Март 4, 2024

Albumin is used commonly across a wide range of clinical settings to improve hemodynamics, facilitate fluid removal, and manage complications cirrhosis. The International Collaboration for Transfusion Medicine Guidelines developed guidelines the use albumin in patients requiring critical care, undergoing cardiovascular surgery, kidney replacement therapy, or experiencing

Язык: Английский

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Diagnosis and Management of Catastrophic Antiphospholipid Syndrome and the Potential Impact of the 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria

Antibodies, Год журнала: 2024, Номер 13(1), С. 21 - 21

Опубликована: Март 12, 2024

Catastrophic antiphospholipid syndrome (CAPS) is a rare and life-threatening condition characterized by the persistence of antibodies occurrence multiple vascular occlusive events. CAPS currently remains diagnostic challenge requires urgent treatment. The diagnosis made difficult classification criteria used as in clinical practice, knowledge derived from retrospective data case reports, confounding biological features, its rapid onset mortality. absence prospective studies limits strength evidence for guideline treatment protocols. This comprehensive review summarizes current understanding disease, discusses how 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria impact definition therapeutic management CAPS, which considered most severe form APS. correct integration APS poised to facilitate diagnosis, particularly critical situations, offering promising avenue improved outcomes.

Язык: Английский

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Diagnosis and management of pediatric acute liver failure: consensus recommendations of the Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN)

Hepatology International, Год журнала: 2024, Номер unknown

Опубликована: Авг. 30, 2024

Timely diagnosis and management of pediatric acute liver failure (PALF) is paramount importance to improve survival. The Indian Society Pediatric Gastroenterology, Hepatology, Nutrition invited national international experts identify review important research questions. These covered the definition, age appropriate stepwise workup for etiology, non-invasive cerebral edema, prognostic scores, criteria listing transplantation (LT) bridging therapies in PALF. Statements recommendations based on evidences assessed using modified Grading Recommendations Assessment, Development Evaluation (GRADE) system were developed, deliberated critically reappraised by circulation. final consensus along with relevant published background information are presented here. We expect that these would be followed adult medical fraternity outcomes PALF patients.

Язык: Английский

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Plasma exchange therapy for the post COVID-19 condition: a phase II, double-blind, placebo-controlled, randomized trial

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 24, 2025

Язык: Английский

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REPLACEMENT FLUIDS IN APHERESIS

Transfusion and Apheresis Science, Год журнала: 2025, Номер 64(3), С. 104140 - 104140

Опубликована: Май 4, 2025

Язык: Английский

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Moderate aerobic exercise improves haematological indices without altering cardio-metabolic enzyme activities in sedentary healthy young adults

BMC Sports Science Medicine and Rehabilitation, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 28, 2025

Regular aerobic exercise regulates cardiorespiratory functions by its effect on specific enzyme activities. This study investigated the immediate effects of moderate haematological parameters and cardio-metabolic enzymes activity in healthy young male female adults. Forty sedentary subjects, twenty males (25 ± 5.6 years; 65 4.0 kg; 176.9 2.5 cm) females 4.5 years, 62 2.9 kg, 175 1.3 volunteered for study. The regimen was intensity lasting 20 min daily a treadmill at incremental speed 3 km/h to 13 14 consecutive days. weight height participants were measured. Blood sample collected via antecubital vein biochemical analysis. namely red blood cell indices, leukocyte differential white count, platelet indices assessed. Cardiac troponin-T, creatine kinase, lactate dehydrogenase N-acetyl-cysteine activated kinase activities assessed before after exercise. result showed significant (p < 0.05) increase RBC (males 7%, 11%) haemoglobin 8%, 8.3%), haematocrit 5%, 14%) 54%, 40%) monocyte count 68%, 55%) days enzymatic dehydrogenase, (CK-NAC), (CK-MB) cardiac troponin-T no change It is concluded that increased maintained

Язык: Английский

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Predicting the Success of Antibody Removal with Therapeutic Plasma Exchange: The Role of Serum Dilutions

American Journal of Transplantation, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Therapeutic Plasma Exchange (TPE) remains a primary therapy for addressing circulating donor-specific antibodies (DSA) against mismatched Human Leukocyte Antigens (HLA), which pose significant challenge to successful transplantation of solid organs and hematopoietic cells. In this study, we evaluated the response five TPE sessions in patients undergoing desensitization, as well who developed antibody-mediated rejection (AMR) post-transplant. Sera collected before after each session was treated with EDTA tested using Single Antigen Bead assay undiluted or 1:4, 1:16, 1:64, 1:256 diluted. The reduction HLA correlated previously established total IgG levels. However, observed that class I antibody levels were reduced by 85-90% while II only 75-80% sessions. We also found dilutions performed on pre-treatment serum predictive TPE. This approach used design TPE-based desensitization protocols highly sensitized across various organ tissue types, treating AMR. Our data suggest dilution may be an effective method assessing likelihood TPE, thereby aiding guidance treatment strategies.

Язык: Английский

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