Silver Nanoparticles: Synthesis and Application for Nanomedicine

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(4), С. 865 - 865

Опубликована: Фев. 17, 2019

Over the past few decades, metal nanoparticles less than 100 nm in diameter have made a substantial impact across diverse biomedical applications, such as diagnostic and medical devices, for personalized healthcare practice. In particular, silver (AgNPs) great potential broad range of applications antimicrobial agents, device coatings, drug-delivery carriers, imaging probes, optoelectronic platforms, since they discrete physical optical properties biochemical functionality tailored by size- shape-controlled AgNPs. this review, we aimed to present major routes synthesis AgNPs, including physical, chemical, biological processes, along with physiochemical characteristics We also discuss underlying intricate molecular mechanisms behind their plasmonic on mono/bimetallic structures, cellular/microbial cytotoxicity, property. Lastly, conclude review summary current AgNPs nanoscience nanomedicine future perspectives these areas.

Язык: Английский

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Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

Nanomaterials, Год журнала: 2018, Номер 8(9), С. 681 - 681

Опубликована: Авг. 31, 2018

During the past few years, silver nanoparticles (AgNPs) became one of most investigated and explored nanotechnology-derived nanostructures, given fact that nanosilver-based materials proved to have interesting, challenging, promising characteristics suitable for various biomedical applications. Among modern potential AgNPs, tremendous interest is oriented toward therapeutically enhanced personalized healthcare practice. AgNPs genuine features impressive development novel antimicrobial agents, drug-delivery formulations, detection diagnosis platforms, biomaterial medical device coatings, tissue restoration regeneration materials, complex condition strategies, performance-enhanced therapeutic alternatives. Given biomedical-related applications efforts were undertaken on understanding intricate mechanisms their biological interactions possible toxic effects. Within this review, we focused latest data regarding use AgNP-based including aspects related toxicity, unique physiochemical properties, biofunctional behaviors, discussing herein intrinsic anti-inflammatory, antibacterial, antiviral, antifungal activities silver-based nanostructures.

Язык: Английский

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Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(7), С. 2375 - 2375

Опубликована: Март 30, 2020

Engineered nanomaterials (ENMs) have gained huge importance in technological advancements over the past few years. Among various ENMs, silver nanoparticles (AgNPs) become one of most explored nanotechnology-derived nanostructures and been intensively investigated for their unique physicochemical properties. The widespread commercial biomedical application nanosilver include its use as a catalyst an optical receptor cosmetics, electronics textile engineering, bactericidal agent, wound dressings, surgical instruments, disinfectants. This, turn, has increased potential interactions AgNPs with terrestrial aquatic environments, well exposure toxicity to human health. In present review, after giving overview we discuss current advances on physiochemical properties specific emphasis biodistribution both vitro vivo following routes exposure. Most studies demonstrated size-, dose- coating-dependent cellular uptake AgNPs. Following NPs exposure, reported Ag accumulation local distant organs. Though there increase number this area, more investigations are required understand mechanisms modes

Язык: Английский

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Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

Materials, Год журнала: 2019, Номер 12(16), С. 2540 - 2540

Опубликована: Авг. 9, 2019

Recent data have reported that the burden of infections related to antibiotic-resistant bacteria in European Union and Economic Area (EEA) can be estimated as cumulative tuberculosis, influenza, human immunodeficiency virus (HIV). In wound management, control represents a crucial issue multi-billion dollar industry worldwide. For diabetic wounds ulcers, particular, are majority amputations patients, which today represent an increasing number elderly. The greatest barrier healing is represented by biofilm, organized consortium encapsulated self-produced extracellular polymeric substance with high resistance conventional antimicrobial therapies. There urgent need for novel anti-biofilm strategies agents and, this scenario, silver nanotechnology has received tremendous attention recent years therapeutically enhanced healthcare. Due its intrinsic therapeutic properties broad-spectrum efficacy, nanoparticles opened new horizons towards approaches healing. This review aims at providing reader overview most progress nanotechnology, special focus on role process.

Язык: Английский

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Silver nanoparticles: Toxicity in model organisms as an overview of its hazard for human health and the environment

Journal of Hazardous Materials, Год журнала: 2019, Номер 390, С. 121974 - 121974

Опубликована: Дек. 24, 2019

Язык: Английский

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Green approaches for the synthesis of metal and metal oxide nanoparticles using microbial and plant extracts

Nanoscale, Год журнала: 2022, Номер 14(7), С. 2534 - 2571

Опубликована: Янв. 1, 2022

Green synthesis approaches are gaining significance as promising routes for the sustainable preparation of nanoparticles, offering reduced toxicity towards living organisms and environment. Nanomaterials produced by green can offer additional benefits, including energy inputs lower production costs than traditional synthesis, which bodes well commercial-scale production. The biomolecules phytochemicals extracted from microbes plants, respectively, active compounds that function reducing stabilizing agents nanoparticles. Microorganisms, such bacteria, yeasts, fungi, algae, have been used in nanomaterials' biological some time. Furthermore, use plants or plant extracts metal metal-based hybrid nanoparticle represents a novel approach has attracted significant research interest. This review discusses various biosynthesis via oxide nanoparticles provides insights into molecular aspects mechanisms biomedical applications. agriculture waste potential bioresource applications biosynthesized is also discussed.

Язык: Английский

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Green synthesis of silver nanoparticles with algae and the importance of capping agents in the process

Journal of Genetic Engineering and Biotechnology, Год журнала: 2021, Номер 19(1), С. 126 - 126

Опубликована: Авг. 24, 2021

Nanoparticle synthesis is a very interesting area of research currently due to the wide applications nanoparticles. The nanoparticles have diameter ranging between 1 and 100 nm they are used in different fields like electronics, pharmaceuticals, cosmetics, biotechnology, medicines, etc. Nanoparticles gained interest researchers their large surface-to-volume ratio capability interact effectively with other particles. Several methods can be for production silver (AgNPs) including chemical, physical, biological. Out all methods, biological method considered cleanest safest as no toxic chemicals process. includes use bacteria, fungi, algae, plant extract synthesis. Algal AgNPs especially because high capacity algae take metals reduce metal ions. Algae widely distributed organism its availability abundant; an added advantage growth under laboratory conditions. These organisms help large-scale at low cost. This review article explains factors that should effective using algae. Capping agents also affect stability It sheds light on importance capping AgNPs. Alga-mediated along modulating size nanoparticles, thereby improving cost-effectiveness environment-friendly production.

Язык: Английский

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<p>Silver nanoparticles: aggregation behavior in biorelevant conditions and its impact on biological activity</p>

International Journal of Nanomedicine, Год журнала: 2019, Номер Volume 14, С. 667 - 687

Опубликована: Янв. 1, 2019

The biomedical applications of silver nanoparticles (AgNPs) are heavily investigated due to their cytotoxic and antimicrobial properties. However, the scientific literature is lacking in data on aggregation behavior nanoparticles, especially regarding its impact biological activity. Therefore, assess potential AgNPs therapeutic applications, two different AgNP samples were compared under biorelevant conditions.Citrate-capped nanosilver was produced by classical chemical reduction stabilization with sodium citrate (AgNP@C), while green tea extract used produce a synthesis approach (AgNP@GTs). Particle size, morphology, crystallinity characterized using transmission electron microscopy. To observe effects most important conditions colloidal stability, grade measurements carried out UV-Vis spectroscopy dynamic light scatterig, MTT assay microdilution method performed evaluate cytotoxicity activity time-dependent manner.The mostly affected pH electrolyte concentration, presence biomolecules can improve particle stability biomolecular corona effect. We demonstrated that high both attenuated toxic effect toward living cells. AgNP@GT proved less prone thus retained degree toxicity.To our knowledge, this first systematic examination simultaneous showed nanoparticle complex systems be estimated simple compounds like chloride glutamine. Electrostatic might not suitable for approaches could offer new frontiers preserve toxicity enhancing stability. importance properly selected methods must emphasized as they profoundly influence therefore

Язык: Английский

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Current Strategies for Noble Metal Nanoparticle Synthesis

Nanoscale Research Letters, Год журнала: 2021, Номер 16(1)

Опубликована: Март 15, 2021

Abstract Noble metals have played an integral part in human history for centuries; however, their integration with recent advances nanotechnology and material sciences provided new research opportunities both academia industry, which has resulted a array of advanced applications, including medical ones. metal nanoparticles (NMNPs) been great importance the field biomedicine over past few decades due to personalized healthcare diagnostics. In particular, platinum, gold silver achieved most dominant spot list, thanks very diverse range industrial biomedical ones such as antimicrobial antiviral agents, diagnostics, drug carriers imaging probes. superior resistance extreme conditions corrosion oxidation is highly appreciated. Notably, two there tremendous advancement development strategies more cost-effective robust NMNP synthesis methods that provide materials tunable physicochemical, optical thermal properties, biochemical functionalities. As result, hybrid NMNPs polymer, graphene, carbon nanotubes, quantum dots core–shell systems developed even enhanced physicochemical characteristics led exceptional diagnostic therapeutic applications. this review, we aim summarize current (Au, Ag Pt).

Язык: Английский

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Silver nanoparticles: Advanced and promising technology in diabetic wound therapy

Materials Science and Engineering C, Год журнала: 2020, Номер 112, С. 110925 - 110925

Опубликована: Апрель 11, 2020

Язык: Английский

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