Acta Pharmaceutica Sinica B,
Год журнала:
2022,
Номер
13(7), С. 2897 - 2925
Опубликована: Ноя. 21, 2022
Despite
the
global
administration
of
approved
COVID-19
vaccines
(e.g.,
ChAdOx1
nCoV-19®,
mRNA-1273®,
BNT162b2®),
number
infections
and
fatalities
continue
to
rise
at
an
alarming
rate
because
new
variants
such
as
Omicron
its
subvariants.
Including
that
are
licensed
for
human
use,
most
currently
in
clinical
trials
administered
via
parenteral
route.
However,
it
has
been
proven
do
not
induce
localized
immunity
upper
respiratory
mucosal
surface,
does
necessarily
lead
sterilizing
immunity.
This
further
supports
necessity
a
vaccine
blocks
main
entrance
route
COVID-19:
nasal
oral
surfaces.
Understanding
mechanism
immune
regulation
M
cells
dendritic
targeting
them
can
be
another
promising
approach
successful
stimulation
system.
paper
reviews
basic
mechanisms
elicited
by
summarizes
practical
aspects
challenges
nanotechnology-based
platform
development,
well
ligand
hybrid
nanoparticles
potentially
effective
target
delivery
agents
vaccines.
BioMedInformatics,
Год журнала:
2024,
Номер
4(1), С. 385 - 409
Опубликована: Фев. 3, 2024
Worldwide,
the
COVID-19
pandemic,
caused
by
brand-new
coronavirus
SARS-CoV-2,
has
claimed
a
sizable
number
of
lives.
The
virus’
rapid
spread
and
impact
on
every
facet
human
existence
necessitate
continuous
dynamic
examination
its
biology
management.
Despite
this
urgency,
does
not
currently
have
any
particular
antiviral
treatments.
As
result,
scientists
are
concentrating
repurposing
existing
medications
or
creating
ones.
This
comprehensive
review
seeks
to
provide
an
in-depth
exploration
our
current
understanding
starting
with
analysis
prevalence,
pathology,
evolutionary
trends.
In
doing
so,
aims
clarify
complex
network
factors
that
contributed
varying
case
fatality
rates
observed
in
different
geographic
areas.
work,
we
explore
world
SARS-CoV-2
mutations
their
implications
for
vaccine
efficacy
therapeutic
interventions.
viral
landscape
pandemic
poses
significant
challenge,
leading
investigate
genetic
foundations
virus
mechanisms
underlying
these
alterations.
Numerous
hypotheses
been
proposed
as
developed,
covering
various
subjects
like
selection
pressures
driving
mutation,
possibility
escape,
consequences
clinical
therapy.
Furthermore,
will
shed
light
trials
investigating
novel
medicines
development,
including
promising
field
drug
repurposing,
providing
window
into
changing
treatment
approaches.
study
provides
compiling
huge
evolving
body
knowledge
highlighting
complexities
public
health,
igniting
additional
investigation
control
unprecedented
global
health
disaster.
Engineering Microbiology,
Год журнала:
2024,
Номер
4(3), С. 100162 - 100162
Опубликована: Июнь 26, 2024
The
coronavirus
disease
2019
(COVID-19)
pandemic
has
highlighted
the
importance
of
developing
novel
vaccines.
An
ideal
vaccine
should
trigger
an
intense
immune
reaction
without
causing
significant
side
effects.
In
this
study
we
found
that
substitution
tryptophan
located
in
cores
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
protein
structures
with
certain
smaller
amino
acids
resulted
variants
melting
temperatures
33–37
°C.
enzyme
activity
assay
indicated
proteolytic
main
proteinase
(3CLpro)
decreased
sharply
when
environmental
temperature
exceeded
temperature,
implying
other
may
lose
most
their
functions
under
same
conditions.
This
finding
suggests
a
virus
variant
containing
engineered
proteins
°C
only
be
functional
upper
tract
where
is
about
33
°C,
but
will
unable
to
invade
internal
organs,
which
maintain
above
37
thus
making
it
possible
construct
temperature-sensitive
attenuated
Acta Pharmaceutica Sinica B,
Год журнала:
2022,
Номер
13(7), С. 2897 - 2925
Опубликована: Ноя. 21, 2022
Despite
the
global
administration
of
approved
COVID-19
vaccines
(e.g.,
ChAdOx1
nCoV-19®,
mRNA-1273®,
BNT162b2®),
number
infections
and
fatalities
continue
to
rise
at
an
alarming
rate
because
new
variants
such
as
Omicron
its
subvariants.
Including
that
are
licensed
for
human
use,
most
currently
in
clinical
trials
administered
via
parenteral
route.
However,
it
has
been
proven
do
not
induce
localized
immunity
upper
respiratory
mucosal
surface,
does
necessarily
lead
sterilizing
immunity.
This
further
supports
necessity
a
vaccine
blocks
main
entrance
route
COVID-19:
nasal
oral
surfaces.
Understanding
mechanism
immune
regulation
M
cells
dendritic
targeting
them
can
be
another
promising
approach
successful
stimulation
system.
paper
reviews
basic
mechanisms
elicited
by
summarizes
practical
aspects
challenges
nanotechnology-based
platform
development,
well
ligand
hybrid
nanoparticles
potentially
effective
target
delivery
agents
vaccines.
