Technology in Cancer Research & Treatment,
Год журнала:
2024,
Номер
23
Опубликована: Янв. 1, 2024
Gastric
cancer
(GC)
is
a
prevalent
malignant
tumor
and
ranks
as
the
second
leading
cause
of
death
among
patients
worldwide.
Due
to
its
hidden
nature
difficulty
in
detection,
GC
has
high
incidence
poor
prognosis.
Traditional
treatment
methods
such
systemic
chemotherapy,
radiotherapy,
surgical
resection
are
commonly
used,
but
they
often
fail
achieve
satisfactory
curative
effects,
resulting
very
low
5-year
survival
rate
for
patients.
Currently,
targeted
therapy
immunotherapy
prominent
areas
research
both
domestically
internationally.
These
hold
promise
GC.
This
article
focuses
on
signaling
pathways
associated
with
development
GC,
well
recent
advancements
applications
immunotherapy.
The
aim
provide
fresh
insights
clinical
Molecular Therapy — Oncolytics,
Год журнала:
2021,
Номер
23, С. 458 - 476
Опубликована: Ноя. 11, 2021
Gastric
cancer
(GC)
is
one
of
the
most
prevalent
malignant
tumor
types
and
third
leading
cause
cancer-related
death
worldwide.
Its
morbidity
mortality
are
very
high
due
to
a
lack
understanding
about
its
pathogenesis
slow
development
novel
therapeutic
strategies.
Long
non-coding
RNAs
(lncRNAs)
class
with
length
more
than
200
nt.
They
play
crucial
roles
in
wide
spectrum
physiological
pathological
processes
by
regulating
expression
genes
involved
proliferation,
differentiation,
apoptosis,
cell
cycle,
invasion,
metastasis,
DNA
damage,
carcinogenesis.
The
aberrant
lncRNAs
has
been
found
various
types.
A
growing
amount
evidence
demonstrates
that
many
aspects
GC
pathogenesis,
including
occurrence,
recurrence,
indicating
their
potential
role
as
biomarkers
diagnosis,
prognosis,
targets
GC.
This
review
systematically
summarizes
biogenesis,
biological
properties,
functions
highlights
critical
clinical
significance
information
may
contribute
better
diagnostics
treatments
for
International Journal of Environmental Research and Public Health,
Год журнала:
2023,
Номер
20(3), С. 2149 - 2149
Опубликована: Янв. 25, 2023
Gastric
cancer
(GC)
is
a
relevant
public
health
issue
as
its
incidence
and
mortality
rates
are
growing
worldwide.
There
recognized
carcinogen
agents,
such
obesity,
tobacco,
meat,
alcohol
consumption
some
dietary
protective
factors.
Strategies
of
early
diagnosis
through
population-based
surveillance
programs
have
been
demonstrated
to
be
effective
in
lowering
the
morbidity
related
GC
countries.
Indeed,
detection
lesions
very
important
order
offer
minimally
invasive
treatments.
Endoscopic
resection
gold
standard
for
with
low
risk
lymph
node
metastasis,
whereas
surgical
mini-invasive
approaches
can
considered
when
endoscopy
not
curative.
This
review
outlines
role
lifestyle
prevention
strategies
GC,
reduce
patients’
factors,
implement
precancerous
conditions
and,
therefore,
improve
lesions.
Furthermore,
we
summarize
available
treatments
gastric
cancer.
Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Янв. 28, 2022
Gastric
cancer
(GC)
is
the
third
leading
cause
of
cancer-related
deaths
worldwide,
with
high
recurrence
and
mortality
rate.
Chemotherapy,
including
5-fluorouracil
(5-FU),
adriamycin
(ADR),
vincristine
(VCR),
paclitaxel
(PTX),
platinum
drugs,
remains
one
fundamental
methods
GC
treatment
has
efficiently
improved
patients'
prognosis.
However,
most
patients
eventually
develop
resistance
to
chemotherapeutic
agents,
failure
clinical
death.
Recent
studies
suggest
that
long
non-coding
RNAs
(lncRNAs)
are
involved
in
drug
by
modulating
expression
resistance-related
genes
via
sponging
microRNAs
(miRNAs).
Moreover,
lncRNAs
also
play
crucial
roles
a
variety
mechanisms,
such
as
regulation
oncogenic
signaling
pathways,
inhibition
apoptosis,
induction
autophagy,
modulation
stem
cells
(CSCs),
promotion
epithelial-to-mesenchymal
transition
(EMT)
process.
Some
exhibit
great
potential
diagnostic
prognostic
biomarkers,
well
therapeutic
targets
for
patients.
Therefore,
understanding
role
their
mechanisms
may
provide
us
novel
insights
developing
strategies
individual
diagnosis
therapy.
In
this
review,
we
summarize
recent
findings
on
underlying
regulated
lncRNAs.
We
discuss
applications
biomarkers
GC.
Genes & Diseases,
Год журнала:
2023,
Номер
10(4), С. 1351 - 1366
Опубликована: Март 24, 2023
Recent
advances
in
deep
sequencing
technologies
have
revealed
that,
while
less
than
2%
of
the
human
genome
is
transcribed
into
mRNA
for
protein
synthesis,
over
80%
transcribed,
leading
to
production
large
amounts
noncoding
RNAs
(ncRNAs).
It
has
been
shown
that
ncRNAs,
especially
long
non-coding
(lncRNAs),
may
play
crucial
regulatory
roles
gene
expression.
As
one
first
isolated
and
reported
lncRNAs,
Cellular & Molecular Biology Letters,
Год журнала:
2021,
Номер
26(1)
Опубликована: Июль 8, 2021
Long
noncoding
RNA
(lncRNA),
urothelial
carcinoma-associated
1
(UCA1)
is
aberrantly
expressed
in
multiple
cancers
and
has
been
verified
as
an
oncogene.
However,
the
underlying
mechanism
of
UCA1
development
gastric
cancer
not
fully
understood.
In
present
study,
we
aimed
to
identify
how
promotes
development.The
Cancer
Genome
Atlas
(TCGA)
Genotype-Tissue
Expression
(GTEx)
data
were
used
analyze
myosin
VI
(MYO6)
expression
cancer.
Western
blot
quantitative
real-time
PCR
(QPCR)
performed
test
level
UCA1/miR-145/MYO6
axis
cell
lines
tissues.
The
roles
vitro
vivo
investigated
by
CCK-8
assay,
flow
cytometry,
siRNAs,
immunohistochemistry,
a
mouse
xenograft
model.
targeted
relationship
among
UCA1,
miR-145,
MYO6
was
predicted
using
LncBase
Predicted
v.2
TargetScan
online
software,
then
luciferase
activity
assay
immunoprecipitation.UCA1
higher
but
miR-145
lower
or
tissues,
compared
adjacent
normal
line
Function
analysis
that
promoted
proliferation
inhibited
apoptosis
cells
vivo.
Mechanistically,
could
bind
directly
found
be
downstream
target
gene
miR-145.
mimics
siRNAs
partly
reverse
effect
on
cells.UCA1
accelerated
through
sponging
upregulate
cancer,
indicating
may
serve
potential
therapeutic
for
Biomedicines,
Год журнала:
2023,
Номер
11(4), С. 1031 - 1031
Опубликована: Март 27, 2023
Individualized
gastric
cancer
(GC)
treatment
aims
at
providing
targeted
therapies
that
translate
the
latest
research
into
improved
management
strategies.
Extracellular
vesicle
microRNAs
have
been
proposed
as
biomarkers
for
GC
prognosis.
Helicobacter
pylori
infection
influences
therapeutic
response
to
and
drivers
of
malignant
changes
in
chronic
gastritis.
The
successful
use
transplanted
mesenchymal
stem
cells
(MSCs)
ulcer
healing
has
raised
interest
studying
their
effects
on
tumor
neovascularization
potential
antiangiogenic
could
cell
secretion
extracellular
vesicles—such
exosomes—in
cells.
MSCs
isolated
from
bone
marrow
order
achieve
angiogenic
modulation
microenvironment
exploit
inherent
migration
tissues.
Bone
marrow-derived
naturally
present
stomach
reported
carry
a
malignancy
risk,
but
effect
is
still
being
researched.
pro-
derived
various
sources
complement
role
immune
regulation
tissue
regeneration
provide
further
understanding
heterogeneous
biology
GC,
aberrant
morphology
vasculature
mechanisms
resistance
drugs.
