Is dynapenic abdominal obesity a risk factor for cardiovascular mortality? A competing risk analysis

Age and Ageing, Год журнала: 2023, Номер 52(1)

Опубликована: Янв. 1, 2023

Dynapenic abdominal obesity has been shown as a risk factor for all-cause mortality in older adults. However, there is no evidence on the association between this condition and cardiovascular mortality.We aimed to investigate whether dynapenic associated with individuals aged 50 older.A longitudinal study an 8-year follow-up was conducted involving 7,030 participants of English Longitudinal Study Ageing study. Abdominal dynapenia were respectively defined based waist circumference (> 102 cm men > 88 women) grip strength (< 26 kg < 16 women). The sample divided into four groups: non-dynapenic/non-abdominal (ND/NAO), non-dynapenic/abdominal (ND/AO), dynapenic/non-abdominal (D/NAO) dynapenic/abdominal (D/AO). outcome mortality. Fine-Grey regression model used estimate function status presence competing events controlled by socio-demographic, behavioural clinical variables.The significantly higher D/AO compared ND/NAO (SHR 1.85; 95% CI: 1.15-2.97). D/NAO also (SHR: 1.62; 1.08-2.44).Dynapenic mortality, larger effect size alone than years. Thus, prevention strategies interventions that enable mitigating harmful effects these conditions should be adopted diminish such risk.

Язык: Английский

---

Cognitive and Physical Intervention in Metals’ Dysfunction and Neurodegeneration

Brain Sciences, Год журнала: 2022, Номер 12(3), С. 345 - 345

Опубликована: Март 3, 2022

Metals—especially iron, copper and manganese—are important elements of brain functions development. Metal-dysregulation homeostasis is associated with brain-structure damage to the motor, cognitive emotional systems, leads neurodegenerative processes. There more evidence that specialized motor exercises can enhance function attenuate neurodegeneration in mechanisms, such as improving neuroplasticity by altering synaptic structure many regions. Psychological physical methods rehabilitation are now becoming increasingly important, pharmacological treatments for movement, symptoms limited. The present study describes patients metal-induced neurotoxicity Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis, Huntington’s disease Wilson’s disease. In our review, we describe (e.g., virtual-reality environments, robotic-assists training) psychological (cognitive training, stimulation, neuropsychological cognitive-behavioral mindfulness-based therapies) methods, significantly quality life independence storage diseases. Storage diseases a diverse group hereditary metabolic defects characterized abnormal cumulation material cells. This topic being addressed due fact plays vital role treatment Unfortunately so far there no specific guidelines concerning physiotherapy disorders, especially regards duration exercise, type exercise intensity, well frequency exercise. part variety these various levels progression. further proves need research be carried out on disorder treatment.

Язык: Английский

---

Impact of sarcopenia on daily functioning: a cross-sectional study among older inpatients

Aging Clinical and Experimental Research, Год журнала: 2022, Номер 34(9), С. 2041 - 2046

Опубликована: Июль 6, 2022

Abstract Background and aim Geriatric patients with sarcopenia are at increased risk for functional decline loss of independence in daily living. This cross-sectional study aims to investigate the impact on different domains status hospitalized geriatric patients. Methods Sarcopenia was assessed hospital admission using recommendations European Working Group Older People 2 (EWGSOP2). Body impedance analysis (BIA) performed determine muscle mass, a pneumatic hand dynamometer used assess strength. The measure (FIM) score, an 18-item tool exploring individual's physical, cognitive social functions, status. Results In 305 included inpatients median age 84.0 years (65.6% female), prevalence 22.6%. Overall, sarcopenic had significant lower FIM scores compared non-sarcopenic ( p = 0.006). An association found items bed/chair/wheelchair transfer 0.047), toilet 0.048), locomotion 0.001), climbing stairs 0.012), comprehension 0.029), interaction 0.028). Conclusion patients, be associated both mobility domains, but not self-care score. Therefore, when addressing inpatients, tailored multi-dimensional training interventions mainly should focus motor-cognitive abilities.

Язык: Английский

---

The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice

AJP Cell Physiology, Год журнала: 2024, Номер 326(5), С. C1320 - C1333

Опубликована: Март 18, 2024

Intramuscular fat (IMF) refers to the lipid stored in skeletal muscle tissue. The number and size of intramuscular adipocytes are primary factors that regulate IMF content. can be derived from either situ or ectopic migration. In this study, it was discovered regulation levels is achieved through chemokine (C-C motif) ligand 5 (CCL5)/chemokine receptor (CCR5) pathway by modulating adipocyte coculture experiments, C2C12 myotubes were more effective promoting migration 3T3-L1 preadipocytes than myoblasts, along with increasing CCL5. Correspondingly, overexpressing CCR5, one receptors CCL5, facilitated their Conversely, application CCL5/CCR5 inhibitor, MARAVIROC (MVC), reduced vivo, transplanted experiments subcutaneous adipose tissue (SCAT) transgenic mice expressing green fluorescent protein (GFP) provided evidence injecting recombinant CCL5 (rCCL5) into promotes muscle. level increased obesity. Blocking axis MVC inhibited deposition, whereas elevated promoted deposition obese mice. These results establish a link between pathway, which could have potential for

Язык: Английский

---

Association of the sarcopenia index with cognitive impairment in a middle-aged to older patients with acute ischemic stroke or transient ischemic attack: A multicenter cohort study

The journal of nutrition health & aging, Год журнала: 2024, Номер 28(7), С. 100241 - 100241

Опубликована: Апрель 25, 2024

The sarcopenia (SI) index, defined as the serum creatinine to cystatin C ratio, is considered a predictor of poor muscle health and malnutrition, which related major adverse cardiovascular events. However, effect SI index on cognitive function in stroke patients remains unknown. In this study, we aimed examine association between longitudinal impairment with acute ischemic or transient attack. Participants who met inclusion criteria national, multicenter, prospective cohort study were enrolled from Impairment Cognition Sleep (ICONS) China National Stroke Registry-3 (CNSR-3). They categorized into four groups according quartile index. Cognitive was assessed using Montreal Assessment (MoCA) scale. Multivariable-adjusted logistic regression models performed evaluate post-stroke (PSCI) at 3-month follow-up. Moreover, discrimination tests used incremental predictive value beyond potential risk factors. Furthermore, subgroup analyses test interactions. Among participants, lower was, worse performance. At follow-up, participants lowest group exhibited 42% increase relative highest [OR 0.58 (95% CI 0.37–0.90)]. after applying test, adding factors resulted slight improvement predicting [NRI 14% (P = 0.01)]. This demonstrated that positively associated higher prevalence PSCI. Monitoring early identification treatment individuals low level may be helpful reduce impairment.

Язык: Английский

---