Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment
Ageing Research Reviews,
Год журнала:
2024,
Номер
101, С. 102480 - 102480
Опубликована: Сен. 3, 2024
Mitochondria
functionally
degrade
as
neurons
age.
Degenerative
changes
cause
inefficient
oxidative
phosphorylation
(OXPHOS)
and
elevated
electron
leakage
from
the
transport
chain
(ETC)
promoting
increased
intramitochondrial
generation
of
damaging
reactive
oxygen
nitrogen
species
(ROS
RNS).
The
associated
progressive
accumulation
molecular
damage
causes
an
increasingly
rapid
decline
in
mitochondrial
physiology
contributing
to
aging.
Melatonin,
a
multifunctional
free
radical
scavenger
indirect
antioxidant,
is
synthesized
matrix
neurons.
Melatonin
reduces
ETC
elevates
ATP
production;
it
also
detoxifies
ROS/RNS
via
SIRT3/FOXO
pathway
upregulates
activities
superoxide
dismutase
2
glutathione
peroxidase.
influences
glucose
processing
by
In
neurogenerative
diseases,
often
adopt
Warburg-type
metabolism
which
excludes
pyruvate
mitochondria
causing
reduced
acetyl
coenzyme
A
production.
Acetyl
supports
citric
acid
cycle
OXPHOS.
Additionally,
required
co-substrate
for
arylalkylamine-N-acetyl
transferase,
rate
limits
melatonin
synthesis;
therefore,
production
diminished
cells
that
experience
making
more
vulnerable
stress.
Moreover,
endogenously
produced
diminishes
during
aging,
further
increasing
components.
More
normal
preserved
aging
with
supplementation.
Язык: Английский
Mitochondrial Quality Control and Melatonin: A Strategy Against Myocardial Injury
Nima Ghavamikia,
Faranak Mehrnoosh,
Farshad Zare
и другие.
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2025,
Номер
39(3)
Опубликована: Фев. 26, 2025
ABSTRACT
Melatonin
exhibits
various
biological
functions,
including
regulation
of
circadian
and
endocrine
rhythms,
anti‐inflammatory,
antioxidant
effects.
Aging
damaged
mitochondria
are
major
sources
oxidative
stress
(OS),
mitochondrial
quality
control
(MQC)
is
crucial
for
maintaining
normal
function.
Myocardial
ischemia‐reperfusion
injury
a
complication
that
can
arise
during
reperfusion
therapy
coronary
heart
disease.
However,
effective
intervention
strategies
currently
lacking.
Mitochondrial
dysfunction
OS
considered
central
mechanisms
myocardial
injury,
with
mitochondrial‐targeted
interventions
being
potential
treatment
direction.
Recent
studies
have
shown
melatonin
improves
structure
function
through
multiple
pathways.
This
review
discusses
the
by
which
ameliorates
focusing
on
MQC,
explores
its
applications
in
prevention
injury.
Язык: Английский
Exploring the therapeutic effect of melatonin targeting common biomarkers in testicular germ cell tumor, prostate adenocarcinoma, and male infertility: an integrated biology approach
Mammalian Genome,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 8, 2025
Язык: Английский
Function of intramitochondrial melatonin and its association with Warburg metabolism
Cellular Signalling,
Год журнала:
2025,
Номер
unknown, С. 111754 - 111754
Опубликована: Март 1, 2025
Язык: Английский
Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats
Antioxidants,
Год журнала:
2024,
Номер
14(1), С. 16 - 16
Опубликована: Дек. 26, 2024
Endoplasmic
reticulum
(ER)
stress
is
a
crucial
factor
in
the
progression
of
obesity-related
type
2
diabetes
(diabesity),
contributing
to
skeletal
muscle
(SKM)
dysfunction,
calcium
imbalance,
metabolic
inflexibility,
and
atrophy.
The
ER
mitochondria
together
regulate
intracellular
levels,
melatonin,
natural
compound
with
antioxidant
properties,
may
alleviate
these
challenges.
Our
previous
research
showed
that
melatonin
raises
preserves
structure
by
enhancing
mitochondrial
function
obese
diabetic
rats.
This
study
further
explores
melatonin's
potential
reduce
vastus
lateralis
(VL)
modulating
unfolded
protein
response
(UPR)
restoring
levels
disrupted
diabesity.
Five-week-old
Zücker
fatty
(ZDF)
rats
lean
littermates
both
sexes
were
divided
into
control
melatonin-treated
groups
(10
mg/kg/day
for
12
weeks).
Flame
atomic
absorption
spectrometry
results
restored
VL
intraorganellar
homeostasis,
increasing
reducing
them
raising
activity
expression
transporters
ZDF
Melatonin
also
decreased
markers
(GRP78,
ATF6,
IRE1α,
PERK)
reduced
pro-apoptosis
(Bax,
Bak,
P-JNK,
cleaved
caspase
3
9)
while
Bcl2
receptor
(MT2)
expression.
These
findings
suggest
protect
against
atrophy
conditions
mitigating
highlighting
its
therapeutic
potential.
Язык: Английский
Actinomycetes: Ultimate Potential Source of Bioactive Compounds Production
Hamza Khalid,
Ayesha Tariq,
Husna Jurrat
и другие.
Futuristic Biotechnology,
Год журнала:
2024,
Номер
unknown, С. 02 - 11
Опубликована: Дек. 31, 2024
Every
day,
increased
microbial
resistance
demands
the
search
for
new
natural
sources
that
can
produce
and
effective
antimicrobial
compounds.
Actinomycetes
are
attractive
microorganisms
with
an
enormous
unlimited
potential
to
economically
biotechnologically
important
metabolites.
Approximately
75%
of
all
bioactive
compounds
produced
so
far
originate
from
this
group
bacteria.
Many
these
have
been
successfully
isolated
converted
into
valuable
medications
other
naturally
derived
synthetic
chemotherapeutic
properties.
The
agents
by
prokaryotes
were
effectively
used
rival
parasites
microbes
assets.
They
include
many
genera,
each
various
novel
products.
For
example,
one
leading
genera
is
Streptomyces,
which
contributes
70%
total
antibiotics
such
as
macrolide,
aminoglycoside,
Rifamycin,
Ivermectin,
chloramphenicol,
a
large
number
medicinally
agents.
It
also
includes
anticancer
well.
Similar
Micromonospora
another
major
source
producing
Tetrocarcins,
Fortimicins,
Antlermicins,
Sagamicins,
Mutamicins,
Verdamicins,
Sisomicins,
Calicheamicin,
gentamicin.
Other
rare
actinomycetes
producers
broad-spectrum
antibiotics,
including
Salinosporamide
A,
Marinomycin
Arenimycin,
Vancomycin,
Abyssomicins,
Proximicins.
Due
expanding
studies,
data
on
production
metabolites
unique
outstanding
phylum
daily.
This
review
has
made
effort
improve
pre-available
knowledge
characterizing
therapeutic
terrestrial
marine
actinomycetes.
Язык: Английский