Will Cannabis or Cannabinoids Protect You from SARS-CoV-2 Infection or Treat COVID-19? DOI Creative Commons
Joshua D. Brown, Amie Goodin

Medical Cannabis and Cannabinoids, Год журнала: 2022, Номер 5(1), С. 32 - 35

Опубликована: Фев. 25, 2022

A recent study reported that two cannabinoids, cannabidiolic acid (CBDA) and cannabigerolic (CBGA), could block cellular entry of the virus causes COVID-19 during in vitro experiments using cell cultures a laboratory • There is low likelihood translating these preclinical research findings to cannabinoid-based therapies due clinical pragmatic concerns with dosing render CBDA CBGA (as well as other cannabinoids) be unlikely candidates for further drug development.These include, example, short half-life CBDA, requiring frequent intervals; high doses required at each interval match inhibitory concentrations studied; cost lack availability CBGA.• Replicating observed effects complex human body interplay compounds within endocannabinoid system, there are known hypothesized safety required.• Cannabinoids, including CBGA, not recommended treatment or prevention SARS-CoV-2 infection.• Recreational medical use currently available cannabis-derived products much lower than those studied provide any benefit against infection.

Язык: Английский

Application of gas chromatography in the analysis of phytocannabinoids: An update (2020–2023) DOI
Lutfun Nahar, Georgiana‐Luminita Gavril, Satyajit D. Sarker

и другие.

Phytochemical Analysis, Год журнала: 2023, Номер 34(8), С. 903 - 924

Опубликована: Ноя. 14, 2023

Abstract Introduction Cannabinoids are a group of compounds that bind to cannabinoid receptors. They possess pharmacological properties like the plant Cannabis sativa . Gas chromatography (GC) is one popular chromatographic techniques has been routinely used in analysis cannabinoids different matrices. Objective The article aims review literature on application GC‐based analytical methods for phytocannabinoids published during period from January 2020 August 2023. Methodology A thorough search was conducted using databases, Web Knowledge, PubMed, Google Scholar, and other relevant materials including books. keywords used, various combinations, with being present all were cannabinoids, , marijuana, analysis, GC, quantitative, qualitative, quality control. From results, only publications incorporate GC reviewed, papers synthetic excluded. Results Since publication early 2020, several have appeared literature. While simple 1D GC–mass spectrometry (MS) GC–flame ionisation detector (FID) still quite common 2D GC‐MS GC‐MS/MS increasingly becoming popular, as these offer more useful data identification quantification use automation sample preparation utilisation mathematical computational models optimisation protocols become norm analysis. Pre‐analyses found derivatisation environmentally friendly extraction protocols. Conclusions phytocannabinoids, especially GC‐MS, remains most preferred compounds. New methods, techniques, models, approaches method introduced.

Язык: Английский

Процитировано

7
The association between hematological markers of inflammation and chronic cannabis use: a systematic review and meta-analysis of observational studies DOI Creative Commons
Reza Moshfeghinia,

Amirhossein Najibi,

Mehrnaz Moradi

и другие.

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Окт. 22, 2024

Introduction Cannabinoids, both natural and synthetic, are a subject of scientific interest. Cannabis is widely used, its impact on health the immune system being studied. The endocannabinoid influences inflammation, including Neutrophil-to-Lymphocyte Ratio (NLR), potential diagnostic tool. Our study investigates connection between cannabis use NLR. Methods systematic review was registered in Prospero (#CRD42023463539). We searched six databases (PubMed, Scopus, Embase, PsycINFO, Web Science, CINAHL Complete) for records English from inception to May 2024. included observational studies that measured (NLR) users control participants. used Newcastle–Ottawa Quality Assessment Scale assess quality studies. selected random-effects model, statistical analysis performed using Stata software version 17. Results Out total 4,054 records, only five articles were inclusion meta-analysis. All these chosen utilized retrospective design. Furthermore, it's worth noting all high quality. In involving 3,359 10,437 non-users, no significant difference NLR found (WMD: 0.12 [-0.16, 0.41], I2: 39.89%). Subgroup healthy schizophrenia participants didn't show differences (p=0.76). Secondary revealed had higher Platelet-to-Lymphocyte (PLR) (67.80 [44.54, 91.06]), neutrophil count (0.68 [0.25, 1.12]), white blood cell (0.92 [0.43, 1.41]), monocyte (0.11 [0.05, 0.16]), Systemic Immune Inflammation Index (SII) (83.48 [5.92, 157.04]) compared non-users Conclusion meta-analysis reveal may affect hematologic parameters, suggesting impact. Complex associations exist, requiring further research. Schizophrenia pro-inflammatory factors discussed, highlighting need ongoing investigation into cannabis-related changes mental health. Systematic registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42023463539.

Язык: Английский

Процитировано

2
Exploring Endocannabinoid System: Unveiling New Roles in Modulating ER Stress DOI Creative Commons

Ilaria Capolupo,

Maria Rosaria Miranda, Simona Musella

и другие.

Antioxidants, Год журнала: 2024, Номер 13(11), С. 1284 - 1284

Опубликована: Окт. 24, 2024

The endoplasmic reticulum (ER) is the organelle mainly involved in maintaining cellular homeostasis and driving correct protein folding. ER-dependent defects or dysfunctions are associated with genesis/progression of several pathological conditions, including cancer, inflammation, neurodegenerative disorders, that directly indirectly correlated to a wide set events collectively named under term "ER stress". Despite recent increase interest concerning ER activity, further research studies needed highlight all mechanisms responsible for failure. In this field, discoveries paved way comprehension strong interaction between stress development endocannabinoid system. activity system mediated by activation cannabinoid receptors (CB), G protein-coupled induce decrease cAMP levels, downstream anti-inflammatory effects. CB drives, most cases, recovery through regulation hallmarks PERK, ATF6, IRE1. review, we focus on role modulating stress, particular attention processes leading UPR oxidative response extinguishment, underlying natural cannabinoids' modulation complex machine.

Язык: Английский

Процитировано

1
The Endocannabinoid System as a Target for Neuroprotection/Neuroregeneration in Perinatal Hypoxic–Ischemic Brain Injury DOI Creative Commons
Andrea Duranti, Gorane Beldarrain,

Antonia Álvarez

и другие.

Biomedicines, Год журнала: 2022, Номер 11(1), С. 28 - 28

Опубликована: Дек. 22, 2022

The endocannabinoid (EC) system is a complex cell-signaling that participates in vast number of biological processes since the prenatal period, including development nervous system, brain plasticity, and circuit repair. This neuromodulatory also involved response to endogenous environmental insults, being special relevance prevention and/or treatment vascular disorders, such as stroke neuroprotection after neonatal injury. Perinatal hypoxia–ischemia leading encephalopathy devastating condition with no therapeutic approach apart from moderate hypothermia, which effective only some cases. overview, therefore, gives current description main components EC (including cannabinoid receptors, ligands, related enzymes), later analyze target for focus on its neurogenic potential hypoxic–ischemic

Язык: Английский

Процитировано

7
Sensitive detection of synthetic cannabinoids in human blood using magnetic polydopamine molecularly imprinted polymer nanocomposites DOI
Jiajia Li, Yong Wang, Anran Liu

и другие.

The Analyst, Год журнала: 2023, Номер 148(19), С. 4850 - 4856

Опубликована: Янв. 1, 2023

Synthetic cannabinoids (SCs) are a series of artificial chemical substances with pharmacological properties similar to those natural and their abuse poses great risk social security human health. However, the highly sensitive detection low concentrations SCs in serum remains challenge. In this work, we developed sensitive, rapid selective method for serum. Magnetic molecularly imprinted polymer (MIP) nanocomposites were prepared through self-polymerization dopamine template molecules on surfaces magnetic beads. 9H-Carbazole-9-hexanol (9CH) was used as molecule because its long chain structure shared six synthetic ability provide specific recognition sites. With these MIP nanoparticles, could be rapidly effectively extracted from blood. The accurately determined by high-performance liquid chromatography-mass spectrometry (HPLC-MS) analysis. limits range 0.1-0.3 ng mL-1. proposed is characterized high sensitivity selectivity, has potential application analysis practical samples.

Язык: Английский

Процитировано

3
A comprehensive review on detection of cannabinoids using hyphenated techniques DOI

Srinidhi Krishnamurthy,

Rashmi Dilip Kadu

Chemical Papers, Год журнала: 2023, Номер 77(7), С. 3501 - 3520

Опубликована: Март 1, 2023

Язык: Английский

Процитировано

2
Clinical Considerations for Cannabis Use and Cardiovascular Health DOI Creative Commons
Ruba Sajdeya, Sebastian Jugl, Robert L. Cook

и другие.

Medical Cannabis and Cannabinoids, Год журнала: 2022, Номер 5(1), С. 120 - 127

Опубликована: Сен. 28, 2022

Язык: Английский

Процитировано

3
The State of Synthetic Cannabinoid Medications for the Treatment of Pain DOI

Anca Maglaviceanu,

Miki Peer,

Jason S. Rockel

и другие.

CNS Drugs, Год журнала: 2024, Номер 38(8), С. 597 - 612

Опубликована: Июль 1, 2024

Язык: Английский

Процитировано

0
The Elusive Truth of Cannabinoids for Rheumatic Pain DOI
Hance Clarke, Sarah Miles, Miki Peer

и другие.

Current Rheumatology Reports, Год журнала: 2024, Номер 26(11), С. 392 - 402

Опубликована: Авг. 9, 2024

Язык: Английский

Процитировано

0
The Impact of Hemp Derived Cannabinoid Potency from Consumer Product Goods on in vitro Lung and Liver Cells DOI Creative Commons
Giovanni A. Ramirez, Maite L. Docampo Palacios, Tesfay Tesfatsion

и другие.

Natural Product Communications, Год журнала: 2024, Номер 19(11)

Опубликована: Ноя. 1, 2024

Background: The surge in the popularity of cannabis has led to an increase number companies producing hemp-derived consumable cannabinoid products. Despite extensive exploration efficacy, safety remains underreported. Any contaminants that are not deemed analytes interest ignored, leaving their identities and profiles a mystery. unregulated nature market places onus on reputable set industry standards for product cleanliness. Objective: This study aimed address this gap by assessing high low potency forms three popular cannabinoids – Delta 8-tetrahydrocannabinol (Δ8-THC), Hexahydrocannabinol (HHC), 9-tetrahydrocannabiphorol (Δ9-THCP). Methods: After identifying contaminants, products were evaluated toxicity vitro using one liver two lung cell lines effort simulate effects oral consumption inhalation. Results: Our revealed none compounds exhibited line, while all both with exception high-potency HHC sample. Conclusion: These findings highlight critical need stringent quality control industry, emphasizing importance consumers prioritize clean, well-tested ensure increasingly market.

Язык: Английский

Процитировано

0