Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR)

The journal of nutrition health & aging, Год журнала: 2025, Номер 29(1), С. 100401 - 100401

Опубликована: Янв. 1, 2025

Aging, a universal and inevitable process, is characterized by progressive accumulation of physiological alterations functional decline over time, leading to increased vulnerability diseases ultimately mortality as age advances. Lifestyle factors, notably physical activity (PA) exercise, significantly modulate aging phenotypes. Physical exercise can prevent or ameliorate lifestyle-related diseases, extend health span, enhance function, reduce the burden non-communicable chronic including cardiometabolic disease, cancer, musculoskeletal neurological conditions, respiratory well premature mortality. influences cellular molecular drivers biological aging, slowing rates-a foundational aspect geroscience. Thus, PA serves both preventive medicine therapeutic agent in pathological states. Sub-optimal levels correlate with disease prevalence populations. Structured prescriptions should therefore be customized monitored like any other medical treatment, considering dose-response relationships specific adaptations necessary for intended outcomes. Current guidelines recommend multifaceted regimen that includes aerobic, resistance, balance, flexibility training through structured incidental (integrated lifestyle) activities. Tailored programs have proven effective helping older adults maintain their capacities, extending enhancing quality life. Particularly important are anabolic exercises, such Progressive resistance (PRT), which indispensable maintaining improving capacity adults, particularly those frailty, sarcopenia osteoporosis, hospitalized residential aged care. Multicomponent interventions include cognitive tasks hallmarks frailty (low body mass, strength, mobility, level, energy) thus preventing falls optimizing during aging. Importantly, PA/exercise displays characteristics varies between individuals, necessitating personalized modalities tailored conditions. Precision remains significant area further research, given global impact broad effects PA. Economic analyses underscore cost benefits programs, justifying broader integration into care adults. However, despite these benefits, far from fully integrated practice people. Many healthcare professionals, geriatricians, need more incorporate directly patient care, whether settings hospitals, outpatient clinics, Education about use isolated adjunctive treatment geriatric syndromes would do much ease problems polypharmacy widespread prescription potentially inappropriate medications. This intersection prescriptive practices offers promising approach well-being An strategy combines pharmacotherapy optimize vitality independence people whilst minimizing adverse drug reactions. consensus provides rationale promotion, prevention, management strategies Guidelines included dosages efficacy randomized controlled trials. Descriptions beneficial changes, attenuation phenotypes, role disability provided. The sarcopenia, neuropsychological emphasized. Recommendations bridge existing knowledge implementation gaps integrate mainstream Particular attention paid it applies geroscience, inter-individual variability adaptation demonstrated adult cohorts. Overall, this foundation applying current base an population span

Язык: Английский

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Meta‐analysis on the interrelationship between sarcopenia and mild cognitive impairment, Alzheimer's disease and other forms of dementia

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2024, Номер 15(4), С. 1240 - 1253

Опубликована: Май 7, 2024

Sarcopenia has been associated with adverse health outcomes, including cognitive dysfunction. However, its specific interrelationship neurocognitive disorders such as mild impairment (MCI), Alzheimer's disease (AD) or other types of dementia not thoroughly explored. This meta-analysis aims to summarize the existing evidence on this interrelationship. systematic review was pre-registered PROSPERO (CRD42022366309) and reported according Preferred Reporting Items for Systematic Reviews Meta-Analyses 2020 guidelines. Databases, PubMed, Embase, CINAHL, Scopus, Web Science, PEDro, SPORTDiscus Cochrane Central Register Controlled Trials, data registry ClinicalTrials.gov were searched from inception 8 June 2023. Observational studies (cross-sectional cohort) interventional reporting association prevalence sarcopenia in MCI, AD adults ≥50 years included. For meta-analysis, pooled odds ratios (OR) 95% confidence intervals (CI) calculated using random-effects/fixed-effects models. Subgroup analyses performed identify potential sources heterogeneity. A total 77 consisting 92 058 subjects finally included qualitative analysis (71 cross-sectional, 4 cohort 2 studies). Studies heterogeneous, different diagnostic criteria define both status. The majority (n = 38) Asian community-dwelling older adults. Most investigated (33/77) MCI (32/77). focusing forms dementia, two Lewy body one study Parkinson's whereas remaining did specify aetiology 21). Three explored between incident only sarcopenia. Two whether an exercise programme could prevent progression AD. information extracted 26 studies. significantly (pooled OR 1.58, CI 1.42-1.76) 14), 2.97, 2.15-4.08) 3) non-AD 1.68, 1.09-2.58) 9). significance magnitude associations differed subgroup by design, population, definition used tool measure showed that is dementia. These findings suggest importance early screening prevention people dysfunction, although further longitudinal research needed clarify causal relationship.

Язык: Английский

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Identification of risk factors and development of a predictive nomogram for sarcopenia in Alzheimer's disease

Alzheimer s & Dementia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Abstract INTRODUCTION Sarcopenia, with its complex diagnostic process, is a likely independent predictor of poor prognosis in patients Alzheimer's disease (AD). However, research on the clinical characteristics and biomarkers AD sarcopenia (ADSA) limited. METHODS This study included 180 ADSA 188 without (ADNSA), evaluated demographics, cognitive function, motor capacity, emotional state, daily living abilities. RESULTS were older, worse functions, more severe depression, poorer social functioning, lower abilities compared to ADNSA patients. Multivariate regression identified age, low Frailty Rating Scale (FRS) scores, serum albumin level, creatinine/cystatin C ratio (CCR) as risk factors for sarcopenia. A nomogram model based these indicators demonstrated high discriminative power utility. DISCUSSION Sarcopenia significantly affects patients’ various functions. The aids early detection personalized interventions AD. Highlights factor (AD), coexistence functions quality life Serum scores are associated both assessment (ADSA). combined indexes age at diagnosis, (CCR), FRS score, levels can aid effectively identifying personalizing population.

Язык: Английский

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Unravelling the Relationship Between Height, Lean Mass, Alzheimer’s Disease and Cognition Through Mendelian Randomization

Genes, Год журнала: 2025, Номер 16(2), С. 113 - 113

Опубликована: Янв. 21, 2025

Background: Genetic evidence from Mendelian randomization (MR) analyses suggests that higher lean mass causally protects against Alzheimer’s disease (AD) and enhances cognitive function. However, the potential confounding role of height, which shares genetic etiology with mass, has not been fully examined. Methods: predictors whole-body were obtained a genome-wide association study (GWAS) performed in UK Biobank cohort (UKB; n = 448,322). height also UKB (height0.5M 455,332) GWAS meta-analysis (height1.5Mn 1,578,425). The outcomes included clinically diagnosed AD (21,982 cases 41,944 controls) performance (n 269,867). All participants European ancestry. We conducted univariable multivariable MR to examine total independent effects on specified under different statistical adjustment strategies. Results: In analyses, genetically proxied (odds ratio [OR] per 1-standard deviation [SD] increase 0.81, 95% confidence interval [CI] 0.72–0.91, p 3.8 × 10−4) (OR 0.90, CI 0.84–0.96, 0.001) associated reduced risk AD. Genetically (β 0.10, 0.08–0.12, 6.24 10−6) 0.07, 0.05–0.08, 1.16 10−15) further improved performance. for height1.5M partially attenuated 0.91, 0.74–1.12, 0.40), whereas height1.5M-AD remained similar after adjusting 0.89, 0.79–1.00, 0.04). Adjustment 0.00, −0.07–0.06, 0.94), maintained 0.03–0.10, 0.001). Conclusions: Height may confound associations between both risk. Residual direct cannot be excluded due limitations power instrument strength MVMR. These findings emphasize necessity when using investigate clinical mass.

Язык: Английский

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The Link Between Oxysterols and Gut Microbiota in the Co-Dysfunction of Cognition and Muscle

Nutrients, Год журнала: 2025, Номер 17(7), С. 1277 - 1277

Опубликована: Апрель 6, 2025

Background/Objectives: Alterations of oxysterols and gut microbiota have been recognized as indicators affecting mild cognitive impairment (MCI) sarcopenia, respectively, whereas their association with co-dysfunction has not investigated. Methods: In this study, a total 1035 individuals were divided into Control (n = 264), MCI 435), possible sarcopenia (MPS, n 336) groups. Cognition muscle indexes, serum oxysterols, measured. Spearman's rank coefficients calculated to determine correlations. Results: Performances global multidimensional tests was successively worse in the Control, MCI, MPS Longer duration five-time chair stand test, lower 6-meter walk speed, handgrip strength observed group, along increased 27-hydroxycholesterol (27-OHC) 5α,6α-epoxycholesterol decreased 5α-Cholest-8(14)-ene-3β,15α-diol (15-HC). Higher concentrations amyloid precursor protein (APP), neurofilament, C-terminal agrin fragment (CAF) discovered The α-diversity group remarkably decreased, followed by shifted abundance microbial taxa, such Alistipes Rikenellaceae. Multiple significant correlations found between cognition indexes oxysterols. Conclusions: Our study indicates that are prominently involved muscle.

Язык: Английский

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Prevalence of and Risk Factors for Sarcopenia in Patients with Epilepsy

Seizure, Год журнала: 2025, Номер 125, С. 162 - 171

Опубликована: Янв. 5, 2025

Язык: Английский

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Cognitive impairment, dementia and sarcopenia in geriatric patients - is there a relationship?

Experimental and Clinical Gastroenterology, Год журнала: 2025, Номер 8, С. 181 - 195

Опубликована: Фев. 3, 2025

Currently, demographic aging of the population continues, and frequency various age-associated pathologies is increasing. Sarcopenia cognitive impairment are often found in patients older age groups, leading to development frailty, decreased quality life, disability premature death. There an association between sarcopenia, frailty impairment. Cognitive physical interrelated: problems dementia more common people with likely become frail. Both decline share pathogenesis mechanisms. The role mediators muscle origin (myokines) occurrence cross-talk muscles brain known. Sufficient activity plays important maintaining not only skeletal muscles, but also functions. On contrary, inactivity one most risk factors for dementia. However, relationship sarcopenia underlying mechanisms remain be addressed. This focus this literature review.

Язык: Английский

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Editorial: Recent advances in research on cognitive frailty and related conditions

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Апрель 7, 2025

Язык: Английский

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Longitudinal Trajectories of Cognitive Function Among Chinese Middle-Aged and Older Adults: The Role of Sarcopenia and Depressive Symptoms

Brain Sciences, Год журнала: 2025, Номер 15(4), С. 408 - 408

Опубликована: Апрель 17, 2025

Objectives: The longitudinal relationship between sarcopenia, depression, and cognitive impairment has been insufficiently studied in China. This study aimed to characterize the association sarcopenia mediating role of depression using nationally representative data. Methods: 7091 middle-aged older adults were analyzed from China Health Retirement Longitudinal Study (CHARLS) across three waves (2011, 2013, 2015). Cognitive trajectories modeled a group-based trajectory model (GBTM), while multivariable ordinal logistic regression was employed evaluate associations with trajectories. depressive symptoms assessed through bootstrap mediation analysis cross-lagged panel modeling (CLPM). Results: Trajectory identified four distinct function patterns: “High Stable” (n = 2563, 36.73%), “Middle group 2860, 38.76%), Decline” 1280, 18.62%), “Low 388, 5.90%). Sarcopenia associated [Overall: OR (95%CI) 0.315 (0.259, 0.382) 0.417 (0.380, 0.459)]. Mediation indicated that accounted for 11.78% demonstrated significant pathway “T1 → T2 T3 sarcopenia”, 5.31% total effect. Conclusions: Our trajectories, significantly worse over time. Depressive mediated function. highlights importance integrating mental health physical interventions address interconnected risks aging.

Язык: Английский

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The combined effect of diabetes mellitus and sarcopenia on depression and cognitive function: insights from the CHARLS cohort, 2011–2020

European Geriatric Medicine, Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

Язык: Английский

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