Cross-Cultural Adaptation and Clinical Validation of the Mini Sarcopenia Risk Assessment Questionnaire in Community-Dwelling Spanish Older Adults

Diagnostics, Год журнала: 2024, Номер 14(19), С. 2123 - 2123

Опубликована: Сен. 25, 2024

(1) Background: The aim was to analyze the reliability and validity of Spanish version Mini Sarcopenia Risk Assessment (MSRA) in older adults. (2) Methods: A total 136 participants (72.24 ± 5.21 years, 68.38% women) took part study. MSRA includes two questionnaires with seven (MSRA-7) five items (MSRA-5). First, (inter-rater test–retest) studied, then scores were compared presence sarcopenia according three different diagnostic criteria other parameters related (clinical validation). (3) Results: analysis showed excellent inter-rater test–retest reliability. As for clinical validation, regardless criteria, both had a high sensitivity (81.82–88.89% MSRA-5 90.91–94.44% MSRA-7), while better specificity (32.00–33.90%) than MSRA-7 (20.80–22.88%). Predictive positive values ranged from 9.57–17.02% (MSRA-5) 9.17–15.54% (MSRA-7), predictive negative (95.24%) (96.30–96.43%). accuracy (36.03–41.18%) (26.47–32.35%), as well area under curve (0.67–0.76 vs. 0.65–0.73, respectively). Higher significantly correlated greater muscle strength, quantity gait speed. (4) Conclusions: adaptation successfully performed, they are reliable clinically valid tools assessing sarcopenia.

Язык: Английский

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Association between self‐reported weight loss and new long‐term care insurance certifications: A 9‐year Japanese older adult cohort study

Geriatrics and gerontology international/Geriatrics & gerontology international, Год журнала: 2024, Номер 24(12), С. 1320 - 1327

Опубликована: Ноя. 5, 2024

Aim This cohort study aimed to assess weight loss associated with new long‐term care insurance (LTCI) certifications over a 9‐year period, accounting for the competing risk of death. Methods We analyzed data from 3749 Japanese individuals aged ≥65 years in Kami Town, Hyogo Prefecture, Japan. Weight was assessed using Kihon Checklist during baseline survey. Data regarding LTCI were collected until March 2022. Cox proportional hazards models used calculate adjusted hazard ratios (HRs) certification because loss, confounding factors. To exclude effect risks, Fine‐Gray regression estimate subdistribution HRs. Subgroup analyses carried out after examination potential interactions between subjective cognitive function, body mass index categories and loss. Results The incidence rate 5.16 per 100 person‐years overall – broken down into 7.02 those 4.97 without. HR 1.35 (95% CI 1.15–1.59). Considering mortality as risk, 1.37 1.16–1.61). Conversely, no interaction observed function or categories. Conclusions Excluding mortality, identified factor certifications. However, Geriatr Gerontol Int 2024; 24: 1320–1327 .

Язык: Английский

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TREM1—Microglia crosstalk: Neurocognitive Disorders

Brain Research Bulletin, Год журнала: 2024, Номер unknown, С. 111162 - 111162

Опубликована: Дек. 1, 2024

Neurocognitive Disorders (NCDs) primarily affect cognitive functions, including learning, memory, perception, and problem-solving. They predominantly arise as pathological sequelae of central nervous system (CNS) disorders. Emerging evidence suggests that microglial inflammatory activation within the hippocampus underlies pathogenesis impairment. Triggering receptor expressed on myeloid cells 1 (TREM1), a pattern-recognition microglia, becomes upregulated in response to injury synergistically amplifies responses mediated by other receptors, leading uncontrolled inflammation. While TREM1 is lowly resting state, its upregulation upon exposure injurious stimuli promotes contributes development NCDs. Consequently, may serve critical microglia-mediated This article reviews current understanding role NCDs pathogenesis.

Язык: Английский

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Alzheimer’s Disease: Understanding Motor Impairments

Brain Sciences, Год журнала: 2024, Номер 14(11), С. 1054 - 1054

Опубликована: Окт. 24, 2024

Alzheimer's disease (AD), the most prevalent neurodegenerative disorder and leading cause of dementia worldwide, profoundly impacts health quality life. While cognitive impairments-such as memory loss, attention deficits, disorientation-predominate in AD, motor symptoms, though common, remain underexplored. These including gait disturbances, reduced cardiorespiratory fitness, muscle weakness, sarcopenia, impaired balance, are often associated with advanced stages AD contribute to increased mortality. Emerging evidence, however, suggests that symptoms may be present earlier can serve predictive markers for older adults. Despite a limited understanding underlying mechanisms driving these several key pathways have been identified, offering avenues further investigation. This review provides an in-depth analysis discussing its progression, potential mechanisms, therapeutic strategies. Addressing alongside decline enhance patient functionality, improve life, support more comprehensive management

Язык: Английский

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The updated prevalence and risk factors of dementia in old adults in China: A cross-sectional study

Journal of Alzheimer s Disease, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

Background The continuously increasing aging population and life expectancy have led to an inconsistent underestimated dementia prevalence in China. An updated epidemiologic study is urgently needed. Objective To update the rate risk factors of Methods For this national cross-sectional study, 20,438 participants aged ≥65 from 28 communities 56 villages 14 centers were recruited using a multistage cluster sampling design between May 2019 December 2019. Participants assessed with series clinical neuropsychological measurements. rates dementia, Alzheimer's disease (AD), vascular (VaD), as well factors, calculated multivariate-adjusted models. Results crude 9.1% (95% CI, 8.7%–9.5%) for 6.0% 5.7%–6.3%) AD, 1.4% 1.2%–1.5%) VaD, 1.8% 1.6%–2.0%) other dementias years. overall sex- age-standardized was 8.8%. Apart AD higher females than males (10.3% versus 7.7%, respectively). Moreover, increased significantly age. Being unmarried having fewer social activities risks main subtypes. Risk not exactly same VaD. Conclusions almost comparable that developed countries individuals These findings may serve new evidence government interventions aging.

Язык: Английский

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Evaluation of Sarcopenia screening indices as predictors of mortality in older patients with Alzheimer’s disease

BMC Geriatrics, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 4, 2024

The study evaluated the effectiveness of sarcopenia indices neutrophils/lymphocytes, platelets/lymphocytes, AST/ALT, and creatinine (Cr)/ cystatin C (CysC)*100 in predicting mortality hospitalized patients with Alzheimer's disease (AD) aged 60 years or older. This retrospective observational survey was undertaken a teaching hospital western China from January 1, 2017, to December 30, 2022. neutrophil/lymphocyte, platelet/lymphocyte, Cr/CysC*100 ratios were used assess presence sarcopenia, upper quartiles as cutoff value. Information on all-cause obtained through telephone interviews electronic medical records between June 2024, 20, 2024. Overall survival (OS) represented time admission death/final follow-up. Cox proportional hazards models applied determine relationships above parameters all causes. information 523 AD retrieved record system. Of these, 329 finally enrolled, whom over age years. use Cr/Cys C*100 indicator found be effective (24.39% vs. 13.77% for those without, P = 0.024). However, application AST/ALT indicators showed no marked differences non-sarcopenia participants. After further logistic regression analysis correction possible variables, participants had an increased risk death relative without (HR 2.179, 95%CI: 1.175–4.044). that only prediction older individuals not predictors.

Язык: Английский

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