Physical frailty, genetic predisposition, and the risks of severe non‐alcoholic fatty liver disease and cirrhosis: a cohort study DOI Creative Commons

Honghao Yang,

Fengrong Ou,

Qing Chang

и другие.

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2024, Номер 15(4), С. 1491 - 1500

Опубликована: Июнь 18, 2024

Abstract Background Frailty, defined as a phenotype of decreased physiological reserves and diminished ability to respond stressors, has been linked the development chronic diseases. Epidemiological evidence connecting frailty non‐alcoholic fatty liver disease (NAFLD) cirrhosis risks remain sparse. We aimed assess longitudinal associations with severe NAFLD in middle‐aged older adults further explore modification role genetic risk on these associations. Methods This study included total 398 386 participants from UK Biobank. Incident cases were ascertained through hospital records death registries. Frailty status was assessed by modified version phenotype, encompassing five key components: weight loss, tiredness, physical activity, gait speed, grip strength. Participants classified pre‐frailty if they met one or two criteria, three more. Genetic predisposition estimated score (GRS) categorized into high, intermediate, low levels according tertiles GRSs. Cox proportional hazards regression model employed estimate hazard ratios (HRs) 95% confidence intervals (CIs) for their Results The mean (standard deviation) age population 56.6 (8.03) years. 214 408 (53.8%) female; 14 924 (3.75%) criteria frailty, 170 498 (42.8%) pre‐frailty, 212 964 (53.5%) non‐frailty. Over median follow‐up 12.0 years, we documented 4439 incident 3323 cases, respectively. Compared non‐frailty, both (HR: 1.50; CI: 1.40–1.60) 1.98; 1.77–2.21) associated increased NAFLD. Similar observed cirrhosis, corresponding HRs (95% CIs) 1.00 (reference), 1.29 (1.20, 1.38), 1.90 (1.66, 2.18). Such consistent across all levels, no interactions between GRSs (all P ≥0.10). level risk, greatest increasement developing 3.36; 2.83–3.99) 2.81; 2.29–3.44) those high risk. Conclusions Our findings indicate that is significant predictor irrespective predisposition.

Язык: Английский

Mapping of rehabilitation interventions and assessment methods for patients with liver cirrhosis: a scoping review DOI Creative Commons
Yuichiro Hosoi, Michiyuki Kawakami, Daisuke Ito

и другие.

BMC Gastroenterology, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 23, 2025

Язык: Английский

Процитировано

0
Physical frailty, genetic predisposition, and the risks of severe non‐alcoholic fatty liver disease and cirrhosis: a cohort study DOI Creative Commons

Honghao Yang,

Fengrong Ou,

Qing Chang

и другие.

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2024, Номер 15(4), С. 1491 - 1500

Опубликована: Июнь 18, 2024

Abstract Background Frailty, defined as a phenotype of decreased physiological reserves and diminished ability to respond stressors, has been linked the development chronic diseases. Epidemiological evidence connecting frailty non‐alcoholic fatty liver disease (NAFLD) cirrhosis risks remain sparse. We aimed assess longitudinal associations with severe NAFLD in middle‐aged older adults further explore modification role genetic risk on these associations. Methods This study included total 398 386 participants from UK Biobank. Incident cases were ascertained through hospital records death registries. Frailty status was assessed by modified version phenotype, encompassing five key components: weight loss, tiredness, physical activity, gait speed, grip strength. Participants classified pre‐frailty if they met one or two criteria, three more. Genetic predisposition estimated score (GRS) categorized into high, intermediate, low levels according tertiles GRSs. Cox proportional hazards regression model employed estimate hazard ratios (HRs) 95% confidence intervals (CIs) for their Results The mean (standard deviation) age population 56.6 (8.03) years. 214 408 (53.8%) female; 14 924 (3.75%) criteria frailty, 170 498 (42.8%) pre‐frailty, 212 964 (53.5%) non‐frailty. Over median follow‐up 12.0 years, we documented 4439 incident 3323 cases, respectively. Compared non‐frailty, both (HR: 1.50; CI: 1.40–1.60) 1.98; 1.77–2.21) associated increased NAFLD. Similar observed cirrhosis, corresponding HRs (95% CIs) 1.00 (reference), 1.29 (1.20, 1.38), 1.90 (1.66, 2.18). Such consistent across all levels, no interactions between GRSs (all P ≥0.10). level risk, greatest increasement developing 3.36; 2.83–3.99) 2.81; 2.29–3.44) those high risk. Conclusions Our findings indicate that is significant predictor irrespective predisposition.

Язык: Английский

Процитировано

1