Influence of Klotho Protein Levels in Obesity and Sarcopenia: A Systematic Review
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1915 - 1915
Опубликована: Фев. 23, 2025
The
Klotho
gene
is
recognized
for
its
anti-aging
properties.
Its
downregulation
leads
to
aging-like
phenotypes,
whereas
overexpression
can
extend
lifespan.
protein
exists
in
three
forms:
α-klotho,
β-klotho
and
γ-klotho.
α-klotho
has
two
isoforms:
a
membrane-bound
form,
primarily
the
kidney
brain,
secreted
klotho
present
blood,
urine,
cerebrospinal
fluid.
functions
as
co-receptor
fibroblast
growth
factor-23
(FGF23),
regulating
phosphate
metabolism.
form
controls
various
ion
channels
receptors,
while
regulates
endocrine
FGFs,
including
FGF19
FGF21.
interaction
between
FGF21
muscle
critical
development
of
sarcopenic
obesity.
This
systematic
review,
registered
PROSPERO
conducted
following
PRISMA
guidelines,
evaluates
levels
individuals
with
obesity
or
study
includes
overweight,
obese,
obese
adults
compared
those
normal
body
mass
index.
After
reviewing
713
articles,
20
studies
were
selected,
observational,
cross-sectional,
cohort
studies,
clinical
trials.
Significant
associations
obesity,
metabolic
syndrome
(MS),
cardiovascular
risk
observed.
Exercise
dietary
interventions
positively
influenced
levels,
which
linked
improved
strength
slower
decline.
potential
biomarker
MS,
Further
research
needed
explore
mechanisms
therapeutic
potential.
Язык: Английский
The Link Between Oxysterols and Gut Microbiota in the Co-Dysfunction of Cognition and Muscle
Nutrients,
Год журнала:
2025,
Номер
17(7), С. 1277 - 1277
Опубликована: Апрель 6, 2025
Background/Objectives:
Alterations
of
oxysterols
and
gut
microbiota
have
been
recognized
as
indicators
affecting
mild
cognitive
impairment
(MCI)
sarcopenia,
respectively,
whereas
their
association
with
co-dysfunction
has
not
investigated.
Methods:
In
this
study,
a
total
1035
individuals
were
divided
into
Control
(n
=
264),
MCI
435),
possible
sarcopenia
(MPS,
n
336)
groups.
Cognition
muscle
indexes,
serum
oxysterols,
measured.
Spearman's
rank
coefficients
calculated
to
determine
correlations.
Results:
Performances
global
multidimensional
tests
was
successively
worse
in
the
Control,
MCI,
MPS
Longer
duration
five-time
chair
stand
test,
lower
6-meter
walk
speed,
handgrip
strength
observed
group,
along
increased
27-hydroxycholesterol
(27-OHC)
5α,6α-epoxycholesterol
decreased
5α-Cholest-8(14)-ene-3β,15α-diol
(15-HC).
Higher
concentrations
amyloid
precursor
protein
(APP),
neurofilament,
C-terminal
agrin
fragment
(CAF)
discovered
The
α-diversity
group
remarkably
decreased,
followed
by
shifted
abundance
microbial
taxa,
such
Alistipes
Rikenellaceae.
Multiple
significant
correlations
found
between
cognition
indexes
oxysterols.
Conclusions:
Our
study
indicates
that
are
prominently
involved
muscle.
Язык: Английский