Clinical and Experimental Medicine, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 15, 2025

Upon stimulation and activation, mast cells (MCs) release soluble mediators, including histamine, proteases, cytokines. These mediators are often stored within cytoplasmic granules in MCs may be released a granulated form. The secretion of cytokines chemokines occurs hours following with the potential to result chronic inflammation. In addition their role allergic inflammation, components tumor microenvironment (TME). MicroRNAs (miRNAs) small RNA molecules that do not encode proteins, but regulate post-transcriptional gene expression by binding 3' non-coding regions mRNAs. This plays crucial function MC, key processes MC proliferation, maturation, apoptosis, activation. It has been demonstrated miRNAs also present extracellular vesicles (EVs) secreted MCs. EVs derived from mediate intercellular communication carrying miRNAs, affecting various diseases diseases, intestinal disorders, neuroinflammation, tumors. findings provide important insights into therapeutic mechanisms targets affect diseases. review discusses relevance miRNA production regulating own activity effect putatively produced other control participation selected pathologies.

Язык: Английский