Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 281 - 332
Опубликована: Янв. 1, 2023
Язык: Английский
RSC Advances, Год журнала: 2025, Номер 15(4), С. 2930 - 2946
Опубликована: Янв. 1, 2025
A series of 3-(2,2-dialkyl-2 H -chromen-4-yl)-2-phenylimidazo[1,2- a ]pyridine derivatives were synthesis. Molecular docking studies and antibacterial evaluation validates as potent druggable agents in future.
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(3), С. 607 - 607
Опубликована: Янв. 30, 2025
The imidazo[1,2-a]pyridine skeleton is widely present in many natural products and pharmaceutical agents. Due to its impressive significant biological activities, such as analgesic, anti-tumor, antiosteoporosis, anxiolytic properties, the derivatization of has attracted widespread attention from chemists. In recent years, progress been made imidazo[1,2-a]pyridines through direct C-H functionalization, especially visible light induction. This review highlights advances light-induced functionalization during past ten some reaction mechanisms are also discussed.
Язык: Английский
Процитировано
0
Advances in heterocyclic chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Beilstein Journal of Organic Chemistry, Год журнала: 2024, Номер 20, С. 628 - 637
Опубликована: Март 19, 2024
The imidazo[1,2- a ]pyridine moiety is present in drugs with several biological activities. most direct way of obtaining this nucleus the Groebke–Blackburn–Bienaymé three-component reaction (GBB-3CR) between aminopyridines, aldehydes, and isocyanides under both Lewis Brønsted acid catalysis. However, catalysts for have major drawbacks such as being expensive, extremely dangerous, strong oxidizing, even explosive. In scenario, heteropolyacids emerge greener safer alternatives due to their very acidity. particular, phosphotungstic (HPW) an economical green attractive catalyst cheap, non-toxic, known its chemical thermal stability. Herein, we report straightforward approach GBB-3CR using HPW ethanol microwave (μw) heating. This convenient environmentally benign methodology broad scope, provides heterobicyclic products high yields (up 99%), low loading (2 mol %) only 30 minutes, allows successful use aliphatic substrates not so frequently explored usual reaction. Furthermore, aforementioned advantages make superior existing ones.
Язык: Английский
Процитировано
1
New Journal of Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Here, we describe the one-pot assembly of imidazo[1,2- a ]pyridine and quinoxaline heterocyclic cores by electrophilic tandem cyclization between 3,5-diaryl substituted 5-hydroxy-3-pyrrolin-2-ones corresponding nitrogen bis-nucleophiles.
Язык: Английский
Процитировано
1
Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown
Опубликована: Окт. 18, 2024
Abstract Imidazoheterocycles have extensive applications in the pharmaceutical industry and agrochemicals. A comprehensive overview has been provided on current advancements electrochemical functionalization of imidazo‐fused heterocycles, which classified into ten different types reactions. Electrochemical synthesis emerged as a highly effective method for producing organic molecules, especially context sustainable development. Employing electrons traceless oxidant, several C−H reactions heterocycles achieved at either C3 or C5 positions. Electrons may serve reducing agent to synthesize pyridine rings that are partially fully saturated imidazo[1,2‐ ]pyridines. The purpose review is attract interest scientific community promote additional research imidazoheterocycles using methods.
Язык: Английский
Процитировано
1
Molecules, Год журнала: 2024, Номер 29(21), С. 5048 - 5048
Опубликована: Окт. 25, 2024
Imidazo[1,2-
Язык: Английский
Процитировано
1
Journal of Saudi Chemical Society, Год журнала: 2024, Номер 28(4), С. 101883 - 101883
Опубликована: Май 29, 2024
A facile, transition-metal-free, HFIP-promoted method for the synthesis of triarylmethanes through direct Friedel-Crafts reactions imidazo[1,2-a]pyridines with chlorohydrocarbon derivatives has been described, which allows efficient containing in good to satisfactory yields at room temperature. This transformation features simple operation, excellent functional group tolerance, and a broad substrate scope.
Язык: Английский
Процитировано
0
European Journal of Organic Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Abstract N,O‐doped aceanthrylenes have been synthesized for the first time via a selective S N Ar reaction or Ullmann‐coupling of phenols, followed by an intramolecular direct arylation. The has carefully optimized and permits synthesis in moderate to excellent yields tolerate various functional groups. aromatic behavior hitherto unknown heterocyclic scaffold further analyzed NICS NICS2BC calculations.
Язык: Английский
Процитировано
0
Science Advances, Год журнала: 2024, Номер 10(49)
Опубликована: Дек. 4, 2024
Imidazo[1,2- a ]pyridines are privileged heterocycles with diverse applications in medicinal chemistry; however, the catalytic asymmetric synthesis of these heterocyclic structures remains underexplored. Herein, we present an efficient and modular approach for atroposelective axially chiral imidazo[1,2- via multicomponent reaction. By utilizing phosphoric acid catalyst, Groebke-Blackburn-Bienaymé reaction involving various 6-aryl-2-aminopyridines, aldehydes, isocyanides gave access to wide range ]pyridine atropoisomers high excellent yields enantioselectivities. Extensive control experiments underscored pivotal role remote hydrogen bonding donor on substrates achieving stereoselectivity reactions. The versatile derivatizations atropisomeric products, especially their as analog NOBINs facile conversion into unique 6,6-spirocyclic further emphasize merits this methodology.
Язык: Английский
Процитировано
0