Synthesis of Novel Nitroimidazole‐Pyrazole Hybrids via an Attractive Methodology of N‐Alkylation of 4(5)‐Nitro‐1H‐imidazole

Journal of Heterocyclic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

ABSTRACT Imidazole is one of the most important heterocyclic rings. This nucleus can be found in a plethora substances different knowledge areas such as medicinal, agrochemical, polymer, and dyestuff. N ‐alkylation reactions involving − 1 atom remarkable tool to synthesize many imidazole derivatives which attached great variety functional groups. In this work, we synthesized 10 new intermediates 4‐chlorobutyl 1‐aryl‐1 H ‐pyrazole‐4‐carboxylates 3(a–j) from ‐pyrazole‐4‐carbonyl chlorides, obtained ‐pyrazole‐4‐carboxylic acids 4(a–j) , 4‐chlorobutan‐1‐ol generated by THF ring‐opening promoted hydrochloric acid. Compounds 4(5)‐nitro‐1 ‐imidazole afford targets 4‐(4‐nitro‐1 ‐imidazol‐1‐yl)butyl 2(a–j) 18%–85% yields.

Язык: Английский

High-Energetic Salts and Metal Complexes: Comprehensive Overview with a Focus on Use in Homemade Explosives (HME)

Molecules, Год журнала: 2024, Номер 29(23), С. 5588 - 5588

Опубликована: Ноя. 26, 2024

Metal-containing compounds form a large and rapidly expanding group of high-energy materials. Many in this class attract the attention non-professionals, who may attempt illegal production explosives. Several these substances have been commercially available pose significant danger if used by terrorists or for criminal purposes. Others are experimental compounds, kinds curiosities, often created pyrotechnics enthusiasts, which can present serious risks to both creators their immediate surroundings. The internet hosts vast amount information, including recipes discussions on forums, private websites, social media, more. This paper aims review variety metal-containing explosives discuss appeal potential accessibility unauthorized individuals.

Язык: Английский