Multimodal Magnetic Resonance Imaging Studies on Non-Motor Symptoms of Parkinson's Disease
Weimin Qi,
Xiaoyan Niu,
Xiuping Zhan
и другие.
IBRO Neuroscience Reports,
Год журнала:
2025,
Номер
18, С. 180 - 190
Опубликована: Янв. 6, 2025
Язык: Английский
Prefrontal cortex iron content in neurodegeneration and healthy subjects: A systematic review
Ibrain,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Iron
accumulation
in
the
prefrontal
cortex
(PFC)
has
been
implicated
neurodegeneration
and
cognitive
decline.
Magnetic
resonance
imaging
(MRI)
enables
noninvasive
quantification
of
brain
iron
content
deposition.
This
review
aimed
to
summarize
evidence
on
MRI‐based
assessment
PFC
healthy
individuals
patients
with
neurodegeneration.
A
systematic
preliminary
literature
was
conducted
using
PubMed,
Scopus,
Web
Science,
Embase
databases.
MRI
techniques
for
capturing
susceptibility
changes
reflecting
iron,
such
as
susceptibility‐weighted
(SWI),
quantitative
mapping
(QSM),
R2*
mapping,
were
included.
Data
extracted,
narrative
synthesis
performed.
Twelve
studies
that
measured
levels
diseases
(five
studies)
subjects
(seven
In
general,
involving
have
found
increased
correlates
impairment.
Aging
reported
age‐related
particularly
dorsolateral,
medial,
anterior
subregions,
increases
age,
is
associated
reduced
dopamine
signaling
poorer
cognition.
techniques,
QSM,
can
quantify
aging.
As
biomarkers,
may
contribute
Longitudinal
combining
advanced
QSM
other
neuroimaging
assessments
further
elucidate
effects
dysregulation
function.
Thus,
our
findings
highlight
importance
a
sensitive
tool
assessing
its
potential
role
understanding
pathogenesis
aging
brain.
Язык: Английский
Editorial for “Simultaneous Increase of Mean Susceptibility and Mean Kurtosis in the Substantia Nigra as an MRI Neuroimaging Biomarker for Early‐Stage Parkinson's Disease: A Systematic Review and Meta‐Analysis”
Journal of Magnetic Resonance Imaging,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 9, 2024
Язык: Английский