Cytometry Part A, Год журнала: 2022, Номер 101(12), С. 995 - 999
Опубликована: Июнь 18, 2022
The importance of personalized/precision medicine for targeted therapies and improved outcomes both in terms efficacy safety health care is by now grounded. We here discuss the current landscape personalized approaches against SARS-CoV-2. A schematic approach illustrated figure text.
Язык: Английский
Progress in Biophysics and Molecular Biology, Год журнала: 2023, Номер 178, С. 32 - 49
Опубликована: Фев. 20, 2023
Язык: Английский
Процитировано
47
European Journal of Pain, Год журнала: 2023, Номер 27(9), С. 1107 - 1125
Опубликована: Фев. 28, 2023
Abstract Background Pain after a SARS‐CoV‐2 acute infection (post‐COVID pain) is becoming new healthcare emergency but remains underestimated and most likely undertreated due to lack of recognition the phenomenon knowledge underlying pain mechanisms. Evidence supporting any particular treatment approach for management post‐COVID lacking. Large variability in patient response standard treatments clinically observed, which has led calls personalized, tailored treating patients with chronic (i.e. ‘precision medicine’). Applying global concerted action towards precision medicine could help guide clinical decision‐making aid more effective treatments. Methods The current position paper discusses factors be considered by clinicians managing ranging from identification phenotype genetic consideration. Results ability into nociceptive, neuropathic, nociplastic or mixed type suggested as first step better planification programme. Further, consideration other factors, such gender, comorbidities, received at phase onset‐associated COVID‐19 symptoms, during hospitalization presence emotional disturbances should implemented Conclusions Accordingly, considering these include multimodal pharmacological non‐pharmacological modalities targeting emotional/cognitive aspects psychological and/or coping strategies), central sensitization‐associated mechanisms neuroscience education), exercise programmes well lifestyle interventions (e.g. nutritional support sleep management). Significance This presents an evidence‐based reasoning pain.
Язык: Английский
Процитировано
13
ACS Biomaterials Science & Engineering, Год журнала: 2023, Номер 10(1), С. 271 - 297
Опубликована: Дек. 14, 2023
Nanotechnology has emerged as a transformative pathway in vaccine research and delivery. Nanovaccines, encompassing lipid nonlipid formulations, exhibit considerable advantages over traditional techniques, including enhanced antigen stability, heightened immunogenicity, targeted distribution, the potential for codelivery with adjuvants or immune modulators. This review provides comprehensive overview of latest advancements applications non-lipid-based nanovaccines current vaccination strategies immunization. The commences by outlining fundamental concepts underlying nanovaccine design before delving into diverse components production processes employed their development. Subsequently, comparative analysis various nanocarriers is presented, elucidating distinct physicochemical characteristics impact on response, along preclinical clinical studies. discussion also highlights how nanotechnology enables possibility personalized combined facilitating creation tailored to meet individual patient needs. ethical aspects concerning use nanovaccines, well safety concerns public perception, are addressed. study underscores gaps challenges that must be overcome adopting practice. offers vital new insights status. It emphasizes significance continuous research, collaboration among interdisciplinary experts, regulatory measures fully unlock enhancing immunization ensuring healthier, more resilient society.
Язык: Английский
Процитировано
11
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 75 - 87
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
South of Russia ecology development, Год журнала: 2025, Номер 19(4), С. 28 - 40
Опубликована: Янв. 21, 2025
Aim. To analyze existing data on the impact of mutations in human genome pathogenesis respiratory viral infections and to discuss their relevance clinical practice. The primary objectives include describing mechanisms genetic mutations, reviewing examples genes that affect susceptibility disease severity evaluating prospects for testing personalized medicine.Research factors influencing demonstrates significant progression outcomes. For instance, IFITM3 gene, which plays a crucial role limiting influenza virus replication, along with its rs12252‐C polymorphism, is linked severe cases influenza. Similarly, TLR7 gene are associated manifestations COVID‐19, particularly males. These findings underscore importance identify individuals at heightened risk emphasize potential medicine enhance patient Additionally, it essential consider interplay between environmental as well social determinants health.This review examines influence progression. It can significantly course these infections. integrating into practice efficiency diagnosis, prognosis treatment emphasized.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 24, 2025
Abstract We performed a retrospective immunological analysis of the antibody response in serum and nasopharyngeal swabs (NPS) obtained from 46 individuals infected with ancestral SARS-CoV-2 Wuhan-Hu-1 strain during first COVID-19 wave Cagliari (Sardinia, Italy), 4-month follow-up after hospital admission. implemented comprehensive mucosal samples using assays established our laboratories. In NPS we evaluated viral load by real time PCR, presence kinetics anti-Spike IgG IgA ELISA as well their anti-Wuhan neutralization activity, showing induction persistence anti-viral immunity at level. Neutralizing antibodies were measured safe pseudovirus-based assay validated comparison standard test live SARS-CoV-2. cross-neutralizing against all major early variants concerns (VoC) sera. Of note, detected remarkable reduction neutralizing activity BA.1 compared to BA.2 BA.5 Omicron subvariants, which was confirmed sera an analogous cohort patients San Raffaele Milan, geographically distant region Italy, virus same period time.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2100 - 2100
Опубликована: Фев. 27, 2025
Genetics and epigenetics are mechanisms proposed for explaining post-COVID-19 condition. This secondary analysis aimed to investigate if DNA methylation levels of the ACE2 promoter different depending on genotype five COVID-19-related polymorphisms in individuals who had been previously hospitalized due SARS-CoV-2 infection. We collected non-stimulated saliva samples from 279 (48.7% female, age: 56.0 ± 12.5 years) COVID-19 survivors. The participants self-reported presence post-COVID symptomatology that started after infection persisted at time appointment. Three potential genotypes rs2285666 rs2074192, TMPRSS2 rs12329760 rs2070788, ACE1 rs1799752 were identified samples. Further, locations (CpG) dinucleotides quantified using bisulfited pyrosequencing. Differences percentage (%) each CpG according analyzed. Participants evaluated up 17.8 (SD: 5.2) months hospital discharge. Eighty-eight percent (88.1%) patients reported least one symptom (mean number symptoms: 3.0; SD: 1.9). Overall, we did not observe significant differences or single nucleoid polymorphisms. study find an association between genetics (genotypes COVID-19-associated polymorphisms) (methylation promoter) a cohort survivors with condition during first wave pandemic.
Язык: Английский
Процитировано
0
Journal of Personalized Medicine, Год журнала: 2025, Номер 15(4), С. 156 - 156
Опубликована: Апрель 17, 2025
Background: This study investigated the role of genetic polymorphisms in IFNAR2, OAS1, OAS3, and ACE2 as predictors Paxlovid treatment response, specifically examining their influence on clinical course laboratory parameters COVID-19 patients. Methods: We analyzed impact genes associated with interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), viral entry (ACE2 rs2074192) individuals treated Paxlovid. Results: Our findings suggest that variations these may modulate immune coagulation pathways context during infection. Specifically, IFNAR2 rs2236757 G allele was alterations inflammatory markers, while OAS1 influenced parameters. Furthermore, specific genotypes were linked to changes such oxygen saturation, leukocyte count, liver function markers Paxlovid-treated Conclusions: These results highlight potential considering factors understanding individual responses informing future personalized approaches.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Ноя. 30, 2022
The COVID-19 pandemic has placed a huge strain on global healthcare and been significant cause of increased morbidity mortality, particularly in at-risk populations. This disease attacks the respiratory systems causes immune dysregulation affected patients creating perfect opportunity for development invasive fungal (IFD). infection can instill significant, poorly regulated pro-inflammatory response. Clinically induced immunosuppression or damage to mucosa facilitate IFD Aspergillus, Mucorales, Candida infections have regularly reported throughout pandemic. Corticosteroids modulators are used treatment COVID-19. Corticosteroid use is also risk factor IFD, but not only reason COVID -19 patients. Specific system through functional exhaustion Natural killer (NK) cells T observed expression markers NK-G2A PD-1. Reduced fungicidal activity neutrophils from indicates that dysfunction/imbalance important factors IFD. significantly population Even if incidence relatively low, size this new will result substantial increase overall, annual number cases. It understand how why certain with developed susceptibility as improve our understanding face future pandemics clinical era immuno-suppression/modulation.
Язык: Английский
Процитировано
18
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(23), С. 16717 - 16717
Опубликована: Ноя. 24, 2023
Long COVID-19 syndrome is present in 5-10% of patients infected with SARS-CoV-2, and there still little information on the predisposing factors that lead to its development. The purpose study was evaluate predictive early symptoms, clinical features role Angiotensin-Converting Enzyme-2 (ACE-2) c.513-1451G>A (rs2106806) c.15643279T>C (rs6629110) polymorphisms susceptibility developing subsequent infectionA total 29 who suffered were recruited a descriptive longitudinal two groups: (n = 16) non-Long 13). Early symptoms during classified by medical service. ACE-2 genotyped using Single Nucleotide Primer Extension (SNPE). Of fatigue, myalgia headache showed high risk increasing susceptibility. Clinical such as emergency care, SARS-CoV-2 reinfection, previous diseases, respiratory disease brain fog also had A allele rs2106806 variant associated an odds ratio (OR) 4.214 (95% CI 2.521-8.853; p < 0.001), T rs6629110 OR 3.754 1.785-6.105; 0.002) This shows polymorphisms, different infection COVID-19.
Язык: Английский
Процитировано
10