mRNA vaccines: The future of prevention of viral infections?

Journal of Medical Virology, Год журнала: 2023, Номер 95(2)

Опубликована: Фев. 1, 2023

Abstract Messenger RNA (mRNA) vaccines against COVID‐19 are the first authorized biological preparations developed using this platform. During pandemic, their administration has been proven to be a life‐saving intervention. Here, we review main advantages of mRNA vaccines, identify further technological challenges met during development platform, and provide an update on clinical progress leading vaccine candidates different viruses that include influenza viruses, human immunodeficiency virus 1, respiratory syncytial virus, Nipah Zika cytomegalovirus, Epstein‐Barr virus. The prospects manufacturing in low‐income countries also discussed. ongoing interest research technology likely overcome some existing for (e.g., related storage conditions immunogenicity components lipid nanoparticles) enhance portfolio diseases which classical formulations already authorized. It may open novel pathways protection infections consequences no safe efficient immunization methods currently available.

Язык: Английский

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Key Considerations during the Transition from the Acute Phase of the COVID-19 Pandemic: A Narrative Review

Vaccines, Год журнала: 2023, Номер 11(9), С. 1502 - 1502

Опубликована: Сен. 19, 2023

The COVID-19 pandemic has been met with an unprecedented response from the scientific community, leading to development, investigation, and authorization of vaccines antivirals, ultimately reducing impact SARS-CoV-2 on global public health. However, is far being eradicated, continues evolve, causes substantial health economic burdens. In this narrative review, we posit essential points its responsible management during transition acute phase pandemic. As discussed, despite Omicron (sub)variant(s) causing clinically milder infections, a negligible pathogen. It requires continued genomic surveillance, particularly if one considers that future (sub)lineages do not necessarily have be milder. Antivirals remain elements in management. former could benefit further development improvements dosing, while seasonal administration latter simplification increase interest tackle vaccine hesitancy. also ensure accessibility pharmaceuticals low-income countries improve understanding their use context long-term goals Regardless location, primary role awareness education must played by healthcare workers, who directly communicate patients serve as models for healthy behaviors.

Язык: Английский

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Assessing the Quality of Life, Coping Strategies, Anxiety and Depression Levels in Patients with Long-COVID-19 Syndrome: A Six-Month Follow-Up Study

Diseases, Год журнала: 2024, Номер 12(1), С. 21 - 21

Опубликована: Янв. 11, 2024

This longitudinal study investigates the psychosocial effects of long-COVID Syndrome, a domain still not extensively researched. It specifically evaluates quality life, coping mechanisms, anxiety and depression levels in COVID-19 survivors, differentiating between those with without Syndrome. Conducted at Victor Babes Hospital for Infectious Diseases Pulmonology Timisoara, Romania, utilized cohort patients diagnosed mild to moderate COVID-19. The following standardized tools: WHOQOL-BREF COPE-60 strategies, Anxiety Depression Scale (HADS), were employed assessment. sample consisted 86 displaying persistent post-acute symptoms 432 asymptomatic 6-month post-discharge mark. Patients frequent reported significantly higher fatigue (8.2 ± 1.4), cognitive difficulties (7.5 1.6), respiratory challenges (7.8 1.3), along markedly lower overall life (7.0 1.5) compared their counterparts. HADS scores revealed elevated (6.8 1.9) (7.1 2.3) symptomatic group. Quality as evaluated through use WHOQOL-BREF, showed across physical (58.8 15.8), mental (56.3 16.4), social domains (50.2 17.5). findings indicated prevalence disengagement (56.4%) emotion-focused strategies (61.8%) group, contrast 30.1% 37.0%, respectively, highlights that Syndrome deteriorates is associated increased levels. prevalent among suggests need enhanced support tailored this subgroup.

Язык: Английский

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COVID-19 and influenza hospitalizations and the role of COVID-19 vaccination in the post-pandemic period: A cross-sectional study from Saudi Arabia

Vaccine, Год журнала: 2025, Номер 52, С. 126937 - 126937

Опубликована: Фев. 26, 2025

Язык: Английский

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Impact of the COVID-19 Pandemic on Attitudes toward Vaccination: Representative Study of Polish Society

Vaccines, Год журнала: 2023, Номер 11(6), С. 1069 - 1069

Опубликована: Июнь 6, 2023

The study explored the association between individuals' attitudes toward vaccination and their actual behavior. We also examined impact of coronavirus disease 2019 (COVID-19) pandemic ongoing debate on changing towards vaccination, specifically within different demographic groups. survey was conducted among a representative sample Poles (N = 805) using computer-assisted web interview (CAWI) technology. As demonstrated, those who identified themselves as strong vaccine supporters were statistically significantly more frequently to be vaccinated with COVID-19 booster doses, follow physician's recommendation any without hesitation, strengthened in confidence vaccines during (p < 0.001 for all). However, over half responders declared moderate supporters/opponents, groups whose further are likely affected by (mis)communication. Importantly, than that weakened pandemic, while 43% not against COVID-19. In addition, demonstrated older better-educated individuals COVID-19-vaccinated p 0.013, respectively). results this imply that, order improve acceptance, it is essential strengthen public health communication avoid errors pandemic.

Язык: Английский

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Retrospective Analysis of the Effectiveness of Remdesivir in COVID-19 Treatment during Periods Dominated by Delta and Omicron SARS-CoV-2 Variants in Clinical Settings

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(6), С. 2371 - 2371

Опубликована: Март 19, 2023

Continuous evaluation of real-world treatment effectiveness COVID-19 medicines is required due to the ongoing evolution SARS-CoV-2 and possible emergence resistance. Therefore, this study aimed analyze, in a retrospective manner, outcomes patients hospitalized with during pandemic waves dominated by Delta Omicron variants treated remdesivir (RDV) (n = 762) comparison demographically clinically matched group not any antivirals 1060). A logistic regression analysis revealed that RDV was associated significantly lower risk death both wave (OR 0.42, 95%CI: 0.29-0.60; p < 0.0001) Omicron-dominated period 0.56, 0.35-0.92; 0.02). Moreover, RDV-treated groups were characterized percentage requiring mechanical ventilation, but difference statistically significant. This first evidence remains effective dominance more pathogenic those cause milder course disease, continues be an essential element therapy.

Язык: Английский

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Reviewing the insights of SARS-CoV-2: Its epidemiology, pathophysiology, and potential preventive measures in traditional medicinal system

Deleted Journal, Год журнала: 2024, Номер 5(2), С. 200147 - 200147

Опубликована: Апрель 24, 2024

Язык: Английский

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A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learning

Clinical Proteomics, Год журнала: 2024, Номер 21(1)

Опубликована: Май 17, 2024

Abstract Background COVID-19 is a complex, multi-system disease with varying severity and symptoms. Identifying changes in critically ill patients’ proteomes enables better understanding of markers associated susceptibility, symptoms, treatment. We performed plasma antibody microarray machine learning analyses to identify novel proteins COVID-19. Methods A case-control study comparing the concentration 2000 age- sex-matched inpatients, non-COVID-19 sepsis controls, healthy control subjects. Machine was used unique proteome signature patients. Protein expression correlated clinically relevant variables analyzed for temporal over hospitalization days 1, 3, 7, 10. Expert-curated protein information Natural language processing (NLP) determine organ- cell-specific expression. Results identified 28-protein model that accurately differentiated patients from ICU (accuracy = 0.89, AUC 1.00, F1 0.89) controls 0.88). An optimal nine-protein (PF4V1, NUCB1, CrkL, SerpinD1, Fen1, GATA-4, ProSAAS, PARK7, NET1) maintained high classification ability. Specific hemoglobin, coagulation factors, hypertension, high-flow nasal cannula intervention ( P < 0.01). Time-course analysis 28 leading demonstrated no significant within cohort. NLP key proteins, digestive nervous systems being systems. Conclusions The distinguishable their subset 9 yielded accurate models are expressed multiple organ proteomic helps elucidate pathophysiology may guide future treatment development.

Язык: Английский

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Effects of the vaccination against SARS-CoV-2 on infections and on hospitalizations in European countries

SN Business & Economics, Год журнала: 2023, Номер 3(3)

Опубликована: Фев. 10, 2023

Abstract Since December 2020 vaccines against the SARS-CoV-2 virus have been available. However, little is known regarding their effects on infections and hospitalizations. To gain insight into this topic we empirically analyze of vaccinations for European countries beginning 2021 to February 2022 with weekly data. We perform panel fixed estimations, GMM estimations nonlinear penalized spline estimations. find a statistically significant positive relationship between share vaccinated people in nine while one estimation output was insignificant. Regarding hospitalizations, six out ten yielded insignificant relationship, three results were weakly negative coefficient indicated relation. Hence, there empirical evidence whereas weak relation The implication our analysis that alone cannot end pandemic. Rather developing effective medicines should be seen as an additional measure.

Язык: Английский

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Risk of COVID-19 infection and the associated hospitalization, ICU admission and mortality in opioid use disorder: a systematic review and meta-analysis

Addiction Science & Clinical Practice, Год журнала: 2022, Номер 17(1)

Опубликована: Ноя. 30, 2022

Opioid use disorder (OUD) as a common drug can affect public health issues, including the COVID-19 pandemic, in which patients with OUD may have higher risk of infection and severe disease. This systematic review meta-analysis was conducted to investigate associated hospitalization, intensive care unit (ICU) admission, mortality OUD.A comprehensive search performed on PubMed, Scopus, Embase, Web Science find studies compared rate outcomes comparison normal population. A random effects model developed estimate odd ratios (OR) 95% confidence interval (CI) between OUD.Out 2647 articles identified through search, eight were included five meta-analysis. Among 73,345,758 participants mean age 57.90 ± 13.4 years, 45.67% male. The findings suggested no significant statistical relationship (OR (95% CI): 1.18 (0.47-2.96), p-value: 0.73). Additionally, had hospitalization CI) 5.98 (5.02-7.13), p-value<0.01), ICU admission 3.47 (2.24-5.39), by COVID-19) OR 1.52(1.27-1.82), pvalue< 0.01).The present that is major factor for need COVID-19. It recommended policymakers healthcare providers adopt targeted methods prevent manage clinical decrease burden COVID-19, especially specific populations such patients.

Язык: Английский

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