bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Фев. 6, 2023
Abstract
To
fully
understand
COVID-19,
it
is
critical
to
identify
and
analyze
all
the
possible
hosts
of
SARS-CoV-2
(the
pathogen
COVID-19)
compare
them
with
other
human
coronaviruses.
In
this
study,
we
collected,
annotated,
performed
taxonomical
ontological
analysis
reported
verified
for
coronaviruses
including
SARS-CoV,
MERS-CoV,
SARS-CoV-2,
four
others
that
cause
common
cold.
A
total
37
natural
19
laboratory
animal
host
were
identified
based
on
experimental
or
clinical
evidence.
Our
ontology-based
found
susceptible
animals
belong
therian
mammals.
Specifically,
these
include
one
wildlife
marsupial
mammal
(i.e.,
Didelphis
virginiana)
36
Eutheria
mammals
(a.k.a.
placental
mammals).
The
are
also
classified
as
While
several
non-therian
(including
snake,
housefly,
zebrafish)
be
likely
hosts,
our
excluded
due
lack
convincing
Genetically
modified
mouse
models
Angiotensin-converting
enzyme
2
(ACE2)
dipeptidyl
peptidase-4
(DPP4)
protein
more
virulent
clear
symptoms.
Coronaviruses
often
became
adaptive
in
after
a
series
viral
passages
mice.
support
knowledge
standardization
analysis,
have
represented
annotated
Coronavirus
Infectious
Disease
Ontology
(CIDO)
provided
ways
automatically
query
knowledge.
Journal of Medical Virology,
Год журнала:
2022,
Номер
95(1)
Опубликована: Сен. 19, 2022
Severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2)
is
the
causative
agent
of
novel
coronavirus
disease
(COVID-19)
pandemic,
which
has
caused
serious
challenges
for
public
health
systems
worldwide.
Due
to
close
relationship
between
animals
and
humans,
confirmed
transmission
from
humans
numerous
animal
species
been
reported.
Understanding
cross-species
SARS-CoV-2
infection
dynamics
in
different
crucial
control
COVID-19
protect
health.
In
this
review,
possible
origins
naturally
susceptible
are
discussed.
Furthermore,
review
categorizes
by
families,
so
as
better
understand
animals.
Veterinary Microbiology,
Год журнала:
2024,
Номер
290, С. 110001 - 110001
Опубликована: Янв. 21, 2024
The
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
is
an
emerging
zoonotic
virus
of
public
and
animal
health
concern,
which
felids
have
been
suggested
as
potential
reservoirs.
Although
SARS-CoV-2
exposure
has
detected
in
domestic
wild
captive
animals
belonging
to
Felidae
family,
surveillance
not
carried
out
free-ranging
so
far.
aim
the
present
study
was
assess
Iberian
lynx
(Lynx
pardinus),
most
endangered
felid
world.
Between
2019
2022,
we
conducted
a
seroepidemiological
276
lynxes.
Our
results
evidenced
limited
(0.4%;
95%CI:
0.0-1.1)
but
negligible
this
species,
increasing
host
range.
circulation
wildlife
evidences
need
integrated
European
monitoring.
Journal of Infection,
Год журнала:
2024,
Номер
88(5), С. 106150 - 106150
Опубликована: Апрель 1, 2024
ObjectivesThe
SARS-CoV-2
pandemic
and
large-scale
genomic
surveillance
provided
an
exceptional
opportunity
to
analyze
mutations
that
appeared
over
three
years
in
viral
genomes.
Here
we
studied
their
epidemic
consequences
for
genomes
from
our
center.MethodsWe
analyzed
61,397
sequenced
respiratory
samples
surveillance.
Mutations
frequencies
were
calculated
using
Nextclade,
Microsoft
Excel,
in-house
Python
script.ResultsA
total
of
22,225
nucleotide
identified,
220
(1.0%)
being
each
at
the
root
≥836
genomes,
classifying
as
'hyperfertile'.
Two
seeded
European
pandemic:
P323L
RNA
polymerase,
associated
with
increased
mutation
rate,
D614G
spike
improved
fitness.
Most
'hyperfertile'
occurred
areas
not
predicted
virulence.
Their
mean
number
was
8±6
(0-22)
per
1,000
nucleotides
gene.
They
3.7-times
more
frequent
accessory
than
informational
genes
(13.9
versus
3.7/1,000
nucleotides).
Particularly,
they
4.1-times
ORF8
polymerase
Interestingly,
stop
codons
present
97
positions,
almost
only
genes,
including
(21/100
codons).Conclusionsmost
did
predict
emergence
a
new
epidemic,
some
indicating
existence
so-named
'non-virulence'
genes.
Frontiers in Veterinary Science,
Год журнала:
2025,
Номер
11
Опубликована: Янв. 3, 2025
Widespread
surveillance
for
SARS-CoV-2
was
conducted
across
wildlife,
captive
animals
in
zoological
collections,
and
domestic
cats
Nebraska
from
2021
to
2023.
The
goal
of
this
effort
determine
the
prevalence,
phylogenetic
spatial
distribution
characteristics
circulating
variants
using
various
diagnostic
methodologies
that
can
utilize
both
antemortem
postmortem
samples,
which
may
be
required
wildlife
such
as
white-tailed
deer.
Statewide
testing
revealed
high
variation
prevalence
among
species,
with
deer
identified
primary
reservoir.
In
2021,
seroprevalence
63.73%
(n
=
91)
39.66%
237)
2022,
while
virus
detection
retropharyngeal
lymph
nodes
(RLN)
16.35%
483)
3.61%
277)
2022.
Phylogenetic
analysis
on
11
positive
samples
2021.
This
presence
four
lineages
Delta
variant:
AY.100,
AY.119,
AY.3,
AY.46.4.
Conversely,
other
species
showed
no
detection,
except
cats,
had
a
low
2.38%
628)
indicating
minimal
exposure.
identification
multiple
underscores
need
ongoing
importance
different
methodologies.
These
efforts
are
critical
understanding
circulation
evolution
animals,
informing
public
health
strategies,
mitigating
risks
zoonotic
transmission
emerging
infectious
diseases.
The
emergence
of
SARS-CoV-2
in
late
2019
triggered
a
global
pandemic
(COVID-19)
that
has
claimed
millions
lives
and
continues
to
impact
public
health
systems
worldwide.
This
review
examines
current
scientific
evidence
regarding
the
virus's
origins,
focusing
on
two
primary
hypotheses:
zoonotic
spillover
laboratory-related
emergence.
A
comprehensive
analysis
peer-reviewed
literature
published
between
December
2023
January
2025
was
conducted,
identifying
relevant
studies
through
searches
PubMed
Scopus
databases.
revealed
strong
phylogenetic
supporting
natural
origin,
with
several
indicating
close
genetic
relationships
bat
coronaviruses.
Environmental
sampling
data
from
Huanan
Seafood
Market
detected
RNA
high
number
environmental
samples
animal
stalls.
While
preponderance
supports
spillover,
absence
definitively
identified
intermediate
host
maintains
some
uncertainty.
concludes
evidence-based
recommendations
for
enhanced
viral
surveillance,
implementation
One
Health
approaches,
strengthened
international
collaboration
frameworks
prevent
future
coronavirus
pandemics.
The
emergence
of
SARS-CoV-2
in
late
2019
triggered
a
global
pandemic
(COVID-19)
that
has
claimed
millions
lives
and
continues
to
impact
public
health
systems
worldwide.
This
review
examines
current
scientific
evidence
regarding
the
virus's
origins,
focusing
on
two
primary
hypotheses:
zoonotic
spillover
laboratory-related
emergence.
A
comprehensive
analysis
peer-reviewed
literature
primarily
published
between
December
2023
January
2025
was
conducted,
identifying
relevant
studies
through
searches
PubMed
Scopus
databases.
Key
earlier
publications
are
also
included
provide
essential
background
context.
revealed
strong
phylogenetic
supporting
natural
origin,
with
several
indicating
close
genetic
relationships
bat
coronaviruses.
Environmental
sampling
data
from
Huanan
Seafood
Market
detected
RNA
high
number
environmental
samples
animal
stalls.
While
preponderance
supports
spillover,
absence
definitively
identified
intermediate
host
maintains
some
uncertainty.
concludes
evidence-based
recommendations
for
enhanced
viral
surveillance,
implementation
One
Health
approaches,
strengthened
international
collaboration
frameworks
prevent
future
coronavirus
pandemics.
The
emergence
of
SARS-CoV-2
in
late
2019
triggered
a
global
pandemic
(COVID-19)
that
has
claimed
millions
lives
and
continues
to
impact
public
health
systems
worldwide.
This
review
examines
current
scientific
evidence
regarding
the
virus's
origins,
focusing
on
two
primary
hypotheses:
zoonotic
spillover
laboratory-related
emergence.
A
comprehensive
analysis
peer-reviewed
literature
primarily
published
between
December
2023
January
2025
was
conducted,
identifying
relevant
studies
through
searches
PubMed
Scopus
databases.
Key
earlier
publications
are
also
included
provide
essential
background
context.
revealed
strong
phylogenetic
supporting
natural
origin,
with
several
indicating
close
genetic
relationships
bat
coronaviruses.
Environmental
sampling
data
from
Huanan
Seafood
Market
detected
RNA
high
number
environmental
samples
animal
stalls.
While
preponderance
supports
spillover,
absence
definitively
identified
intermediate
host
maintains
some
uncertainty.
concludes
evidence-based
recommendations
for
enhanced
viral
surveillance,
implementation
One
Health
approaches,
strengthened
international
collaboration
frameworks
prevent
future
coronavirus
pandemics.
Biomedical Technology,
Год журнала:
2023,
Номер
4, С. 24 - 27
Опубликована: Март 22, 2023
Coronavirus
disease
2019
(COVID-19),
a
severely
spreading
pandemic,
has
dramatically
brought
physiological
and
economical
burdens
to
people.Although
the
injectable
vaccines
have
some
achievements
for
coronavirus
defense,
they
still
generate
accompanied
pain,
untoward
reaction
cannot
take
part
in
mucosal
immunity.Inhalable
vaccines,
as
safe,
facile
efficient
strategy,
been
presented
protect
body
from
virus
by
inducing
robust
immunity.Here,
we
give
perspective
of
an
inhalable
COVID-19
vaccine
composed
lung-derived
exosomes
(a
type
virus-like
particle)
conjugated
with
viral
receptor-binding
domain.The
lungderived
act
carriers,
such
particles
successfully
reach
at
lung
reveal
wider
distribution
longer
retention
on
respiratory
mucosa.In
addition,
induce
high
production
specific
antibodies
T
cells
lung,
significantly
protecting
host
against
invasion.It
is
conceived
that
long-term
stability
wound
open
new
avenue
delivery
further
achieve
popularization
pandemic.
ACS Pharmacology & Translational Science,
Год журнала:
2023,
Номер
6(9), С. 1248 - 1265
Опубликована: Авг. 16, 2023
The
appearance
of
several
coronavirus
pandemics/epidemics
during
the
last
two
decades
(SARS-CoV-1
in
2002,
MERS-CoV
2012,
and
SARS-CoV-2
2019)
indicates
that
humanity
will
face
increasing
challenges
from
coronaviruses
future.
emergence
new
strains
with
similar
transmission
characteristics
as
mortality
rates
to
SARS-CoV-1
(∼10%
mortality)
or
(∼35%
future
is
a
terrifying
possibility.
Therefore,
getting
enough
preparations
such
risks
an
inevitable
necessity.
present
study
aims
review
drug
achievements
fight
against
combined
perspective
derived
pharmacology,
pharmacotherapy,
medicinal
chemistry
insights.
Appreciating
all
efforts
made
past
few
years,
there
strong
evidence
desired
results
have
not
yet
been
achieved
research
this
area
should
still
be
pursued
seriously.
By
expressing
some
pessimistic
possibilities
concluding
discovery
pharmacotherapy
COVID-19
successful
so
far,
short
essay
tries
draw
attention
responsible
authorities
more
prepared
epidemics/pandemics.
