Taxonomical and ontological analysis of verified natural and laboratory human coronavirus hosts DOI Creative Commons
Yang Wang,

Muhui Ye,

Fengwei Zhang

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Фев. 6, 2023

Abstract To fully understand COVID-19, it is critical to identify and analyze all the possible hosts of SARS-CoV-2 (the pathogen COVID-19) compare them with other human coronaviruses. In this study, we collected, annotated, performed taxonomical ontological analysis reported verified for coronaviruses including SARS-CoV, MERS-CoV, SARS-CoV-2, four others that cause common cold. A total 37 natural 19 laboratory animal host were identified based on experimental or clinical evidence. Our ontology-based found susceptible animals belong therian mammals. Specifically, these include one wildlife marsupial mammal (i.e., Didelphis virginiana) 36 Eutheria mammals (a.k.a. placental mammals). The are also classified as While several non-therian (including snake, housefly, zebrafish) be likely hosts, our excluded due lack convincing Genetically modified mouse models Angiotensin-converting enzyme 2 (ACE2) dipeptidyl peptidase-4 (DPP4) protein more virulent clear symptoms. Coronaviruses often became adaptive in after a series viral passages mice. support knowledge standardization analysis, have represented annotated Coronavirus Infectious Disease Ontology (CIDO) provided ways automatically query knowledge.

Язык: Английский

The mutation point of view of the SARS‐CoV‐2 HV.1 lineage DOI
Alessandra Ciccozzi, Pier Luigi Fiori, Marco Casu

и другие.

Journal of Medical Virology, Год журнала: 2024, Номер 96(1)

Опубликована: Янв. 1, 2024

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.

Язык: Английский

Процитировано

3
SARS-CoV-2 Prevalence and Variant Surveillance among Cats in Pittsburgh, Pennsylvania, USA DOI Creative Commons
Santhamani Ramasamy, Abhinay Gontu, Sabari Nath Neerukonda

и другие.

Viruses, Год журнала: 2023, Номер 15(7), С. 1493 - 1493

Опубликована: Июнь 30, 2023

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects many mammals, and SARS-CoV-2 circulation in nonhuman animals may increase the risk of novel variant emergence. Cats are highly susceptible to infection, there were cases virus transmission between cats humans. The objective this study was assess prevalence infection an urban setting. We investigated infections domestic community city Pittsburgh (n = 272). While no tested positive for viral RNA, 35 (12.86%) SARS-CoV-2-antibody-positive. Further, we compared a cat-specific experimental lateral flow assay (eLFA) species-agnostic surrogate neutralization (sVNT) antibody detection 71). eLFA demonstrated 100% specificity sVNT. also showed sensitivity sera with >90% inhibition 63.63% 40-89% Using variant-specific pseudovirus (pVNT) antigen cartography, found presence antibodies pre-Omicron Omicron variants. Hence, approach proves valuable identifying cat exposure different Our results highlight continued warrant coordinated surveillance efforts.

Язык: Английский

Процитировано

6
Animal models for COVID-19 and tuberculosis DOI Creative Commons
Björn Corleis, Max Bastian, Donata Hoffmann

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Авг. 11, 2023

Respiratory infections cause tremendous morbidity and mortality worldwide. Amongst these diseases, tuberculosis (TB), a bacterial illness caused by

Язык: Английский

Процитировано

5
Current state-of-the-art and potential future therapeutic drugs against COVID-19 DOI Creative Commons
Ailong Sha, Yi Liu, Haiyan Hao

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11

Опубликована: Авг. 25, 2023

The novel coronavirus disease (COVID-19) continues to endanger human health, and its therapeutic drugs are under intensive research development. Identifying the efficacy toxicity of in animal models is helpful for further screening effective medications, which also a prerequisite enter clinical trials. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) invades host cells mainly by S protein on surface. After SARS-CoV-2 RNA genome injected into cells, M will help assemble release new viruses. RdRp crucial virus replication, assembly, particles. This review analyzes discusses 26 anti-SARS-CoV-2 based their mechanism action, effectiveness safety different models. We propose five be most promising next stage trial research, thus providing reference future drug

Язык: Английский

Процитировано

4
Molecular basis of hippopotamus ACE2 binding to SARS-CoV-2 DOI

Ruirui Yang,

Pu Han, Pengcheng Han

и другие.

Journal of Virology, Год журнала: 2024, Номер 98(5)

Опубликована: Апрель 9, 2024

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a wide range of hosts, including hippopotami, which are semi-aquatic mammals and phylogenetically closely related to Cetacea. In this study, we characterized the binding properties hippopotamus angiotensin-converting enzyme (hiACE2) spike (S) protein receptor domains (RBDs) SARS-CoV-2 prototype (PT) variants concern (VOCs). Furthermore, cryo-electron microscopy (cryo-EM) structure PT S complexed with hiACE2 was resolved. Structural mutational analyses revealed that L30 F83, specific hiACE2, played crucial role in hiACE2/SARS-CoV-2 RBD interaction. addition, comparative structural analysis ACE2 orthologs suggested cetaceans may have potential be infected by SARS-CoV-2. These results provide molecular insights into susceptibility hippopotami suggest risk VOCs spillover necessity for surveillance. IMPORTANCE The first artiodactyl wherein infection been reported. Exploration invasion mechanism will important information surveillance as well other cetaceans. Here, found could efficiently bind RBDs (VOCs) facilitate transduction pseudoviruses hiACE2-expressing cells. cryo-EM elucidated few critical residues RBD/hiACE2 interface, especially F83 unique contributed decreased affinity compared human ACE2. Our work provides insight cross-species transmission highlights monitoring host jumps events on semi-aquatic/aquatic mammals.

Язык: Английский

Процитировано

1
Survey of severe acute respiratory syndrome coronavirus 2 in captive and free-ranging wildlife from Spain DOI Creative Commons
Leira Fernández‐Bastit, David Cano‐Terriza, Javier Caballero‐Gómez

и другие.

Veterinary Research, Год журнала: 2024, Номер 55(1)

Опубликована: Июль 19, 2024

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), considered a zoonotic agent of wildlife origin, can infect various animal species, including in free-range and captive environments. Detecting susceptible species potential reservoirs is crucial for preventing the transmission, spread, genetic evolution, further emergence viral variants that are major threats to global health. This study aimed detect exposure or infection by SARS-CoV-2 420 animals from 40 different terrestrial aquatic mammals, regions Spain during 2020–2023 disease 19 (COVID-19) pandemic. In total, 8/137 were positive antibodies against receptor binding domain and/or nucleoprotein according independent ELISAs. However, only one ELISA-positive sample bottlenose dolphin ( Tursiops truncatus ) tested neutralizing with low titre (SNT 50 38.15) virus neutralization test. Cetaceans expected have high risk early predictive studies due similarity their angiotensin converting enzyme cell humans. Moreover, 283 analysed RNA using RT-qPCR, none positive. Our results reinforce importance considering cetaceans at support taking preventive biosecurity measures when interacting them, especially presence individuals suspected confirmed COVID-19. Although most this negative exposure, ongoing surveillance potentially important prevent future spillover events novel reservoirs.

Язык: Английский

Процитировано

1
Emerging infectious diseases never end: The fight continues DOI Open Access
Yang Yang, Liping Guo, Hongzhou Lu

и другие.

BioScience Trends, Год журнала: 2023, Номер 17(3), С. 245 - 248

Опубликована: Июнь 15, 2023

Emerging infectious diseases have accompanied the development of human society while causing great harm to humans, and SARS-CoV-2 was only one in long list microbial threats. Many viruses existed their natural reservoirs for a very time, spillover from hosts humans via interspecies transmission serves as main source emerging diseases. Widely existing capable utilizing receptors infect cells animals signal possible outbreak another viral infection near future. Extensive close collaborative surveillance across nations, more effective wildlife trade legislation, robust investment into applied basic research will help combat pandemics new

Язык: Английский

Процитировано

3
The panzootic potential of SARS-CoV-2 DOI Creative Commons
Makenzie E. Mabry, Angela Fanelli, Carla Mavian

и другие.

BioScience, Год журнала: 2023, Номер 73(11), С. 814 - 829

Опубликована: Ноя. 1, 2023

Each year, SARS-CoV-2 is infecting an increasingly unprecedented number of species. In the present article, we combine mammalian phylogeny with genetic characteristics isolates found in mammals to elaborate on host-range potential SARS-CoV-2. Infections nonhuman mirror those contemporary viral strains circulating humans, although, certain species, extensive circulation has led unique signatures. As other recent studies, that conservation ACE2 receptor cannot be considered sole major determinant susceptibility. However, are able identify clades and families as candidates for increased surveillance. On basis our findings, argue use term panzootic could a more appropriate than pandemic describe ongoing scenario. This better captures magnitude host range would hopefully inspire inclusive policy actions, including systematic screenings, support management this worldwide event.

Язык: Английский

Процитировано

2
SARS-CoV-2 Secondary Spillover: From Doubt to Evidence DOI Creative Commons
AbdulRahman A. Saied, Faten F. Mohammed, Asmaa A. Metwally

и другие.

IntechOpen eBooks, Год журнала: 2024, Номер unknown

Опубликована: Фев. 19, 2024

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the culprit behind disease 2019 (COVID-19) and it believed that bats may have been source. SARS-CoV-2 can naturally infect humans various animal species, including pets, farm animals, zoo wild animals might serve as potential reservoirs for viral transmission to humans. Most infected with are associated exposure humans; therefore, characterized by zoonosis reverse zoonosis. It critical quickly detect classify variants of concern in both domestic animals. In addition, it’s possible novel emerging due mutation, making infection incidental hosts worrying. Here, we discuss most recent information on spreading among humans, importance genomic research, active surveillance these help us understand spread viruses emergence variants.

Язык: Английский

Процитировано

0
Whole-genome sequencing of SARS-CoV-2 from the initial cases of domestic cat infections in Canada DOI Open Access
Asma Sultana, Dorothee Bienzle, J. Scott Weese

и другие.

Microbiology Resource Announcements, Год журнала: 2024, Номер 13(4)

Опубликована: Фев. 27, 2024

ABSTRACT Two cat nasal swabs from Canada’s earliest confirmed SARS-CoV-2 positive domestic cats were sequenced to over 99% genome coverage. One had lineage A.23.1 not reported before in animals. Both sequences have multiple spike gene mutations and clustered closely with human-derived the global phylogenetic tree.

Язык: Английский

Процитировано

0