Virus Research, Год журнала: 2023, Номер 339, С. 199285 - 199285
Опубликована: Ноя. 27, 2023
Язык: Английский
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Янв. 17, 2024
Despite the clear benefits demonstrated by immunotherapy, there is still an inevitable off-target effect resulting in serious adverse immune reactions. In recent years, research and development of Drug Delivery System (DDS) has received increased prominence. decades development, DDS ability to deliver drugs a precisely targeted manner mitigate side effects advantages flexible control drug release, improved pharmacokinetics, distribution. Therefore, we consider that combining cancer immunotherapy with can enhance anti-tumor ability. this paper, provide overview latest delivery strategies briefly introduce characteristics based on nano-carriers (liposomes, polymer nano-micelles, mesoporous silica, extracellular vesicles, etc.) coupling technology (ADCs, PDCs protein degradation). Our aim show readers variety platforms under different mechanisms, analyze their limitations, more superior accurate targeting for immunotherapy.
Язык: Английский
Процитировано
16
Journal of Biomedical Science, Год журнала: 2025, Номер 32(1)
Опубликована: Янв. 21, 2025
Abstract Nucleic acid vaccines have emerged as crucial advancements in vaccine technology, particularly highlighted by the global response to COVID-19 pandemic. The widespread administration of mRNA against billions globally marks a significant milestone. Furthermore, approval an for Respiratory Syncytial Virus (RSV) this year underscores versatility technology. In oncology, combination encoding neoantigens and immune checkpoint inhibitors (ICIs) has shown remarkable efficacy eliciting protective responses diseases like melanoma pancreatic cancer. Although use DNA been limited India, inherent stability at room temperature cost-effectiveness present viable option that could benefit developing countries. These advantages may help address some challenges associated with vaccines. Currently, several trials are exploring DNA-encoded ICIs across various cancer types. studies highlight promising role nucleic acid-based next generation immunotherapeutic agents treatment. This review will delve into recent current developmental status both DNA-based
Язык: Английский
Процитировано
1
Biomedical Signal Processing and Control, Год журнала: 2025, Номер 104, С. 107608 - 107608
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
1
MedComm – Oncology, Год журнала: 2024, Номер 3(1)
Опубликована: Март 1, 2024
Abstract Synthetic lethality (SL), a genetic concept, has revolutionized the development of antitumor therapies by providing avenues to target previously “undruggable” targets with enhanced specificity for tumor cells over normal tissue. The principles SL have expanded beyond definitions encompass biological functions, including genome stability, cell cycle regulation, death mechanisms, cellular metabolism, cell–cell interactions, and microenvironment (TME). Tumor inactivated survival pathways are sensitive therapeutic inhibition compensatory while remain unaffected. Exploiting based on functional contexts potential significantly improve cancer patient reducing resistance targeted enhancing efficacy when combined other treatment modalities. This review explores underlying mechanisms synthetic interactions (SLI) characterized functions in individual TME. We also provide comprehensive summary strategies leveraging dynamic nature SLI overcome resistance. Additionally, we discuss various approaches models screening designing potent agents tailored specific needs patients, as well combining drugs treatment. offers valuable insights into harnessing promising avenue precision therapy.
Язык: Английский
Процитировано
7
Journal of Virology, Год журнала: 2024, Номер 98(3)
Опубликована: Фев. 27, 2024
ABSTRACT Ferroptosis, a form of programmed cell death characterized by iron-dependent lipid peroxidation, has recently gained considerable attention in the field cancer therapy. There is significant crosstalk between ferroptosis and several classical signaling pathways, such as Hippo pathway, which suppresses abnormal growth frequently aberrant tumor tissues. Yes-associated protein 1 (YAP), core effector molecule abnormally expressed activated variety malignant We previously proved that oncolytic Newcastle disease virus (NDV) to kill cells. NDV been used therapy; however, its mechanism not completely understood. In this study, we demonstrated exacerbated cells inducing ubiquitin-mediated degradation YAP at Lys90 through E3 ubiquitin ligase parkin (PRKN). Blocking suppressed NDV-induced suppressing expression Zrt/Irt-like 14 (ZIP14), metal ion transporter regulates iron uptake. These findings demonstrate degradation. Our study provides new insights into highlights critical role viruses play treatment drug-resistant cancers. IMPORTANCE The being developed for use treatment; still suppressor dysregulated tissues due yes-associated (YAP) activation. have degrades induce promote replication Notably, was found reveals induces an agent treatment.
Язык: Английский
Процитировано
5
Marine Drugs, Год журнала: 2024, Номер 22(7), С. 307 - 307
Опубликована: Июнь 30, 2024
Oncolytic virotherapy is expected to provide a new treatment strategy for cancer. Aphrocallistes vastus lectin (AVL) Ca2+-dependent receptor containing the conserved domain of C-type and hydrophobic N-terminal region, which can bind bird’s nest glycoprotein D-galactose. Our previous studies suggested that oncolytic vaccinia virus (oncoVV) armed with AVL gene exerted remarkable replication antitumor effects in vitro vivo. In this study, we found oncoVV-AVL may reprogram metabolism hepatocellular carcinoma cells promote ROS, elevated ROS subsequently promoted viral induced apoptosis. This study will theoretical basis application liver
Язык: Английский
Процитировано
4
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Авг. 21, 2024
Colorectal cancer is the third most common and second lethal in world. The main cause of disease due to dietary behavioral factors. treatment this complex mainly based on traditional treatments, including surgery, radiotherapy, chemotherapy. Due its high prevalence morbidity, more effective treatments with fewer side effects are urgently needed. In recent years, immunotherapy has become a potential therapeutic alternative one fastest-developing treatments. Immunotherapy inhibits tumor growth by activating or enhancing immune system recognize attack cells. This review presents latest immunotherapies for checkpoint inhibitors, cell therapy, tumor-infiltrating lymphocytes, oncolytic viruses. Some these have shown promising results clinical trials used treatment.
Язык: Английский
Процитировано
4
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189270 - 189270
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(6), С. 403 - 403
Опубликована: Март 10, 2025
The tumor microenvironment is a dynamic and complex three-dimensional network comprising the extracellular matrix diverse non-cancerous cells, including fibroblasts, adipocytes, endothelial cells various immune (lymphocytes T B, NK dendritic monocytes/macrophages, myeloid-derived suppressor innate lymphoid cells). A constantly rapidly growing number of studies highlight critical role these in shaping cancer survival, metastatic potential therapy resistance. This review provides synthesis current knowledge on modulating cellular progression response to treatment.
Язык: Английский
Процитировано
0
Genes & Diseases, Год журнала: 2025, Номер unknown, С. 101599 - 101599
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0