Exploring the mechanism of comorbidity in patients with T1DM and COVID-19: Integrating bioinformatics and Mendelian randomization methods

Medicine, Год журнала: 2024, Номер 103(42), С. e40128 - e40128

Опубликована: Окт. 18, 2024

During the coronavirus disease 2019 (COVID-19) pandemic, incidence of type 1 diabetes mellitus (T1DM) has increased. Additionally, evidence suggests that individuals with may have increased susceptibility to severe acute respiratory syndrome 2 infection. However, specific causal relationships and interaction mechanisms between T1DM COVID-19 remain unclear. This study aims investigate relationship COVID-19, utilizing differential gene expression Mendelian randomization analyses. Differentially expressed sets from datasets GSE156035 GSE171110 were intersected identify shared genes, analyzed for functional enrichment. models employed assess effects, revealing no direct link in European population ( P > .05). Notably, DNA replication sister chromatid cohesion (DSCC1) showed negative associations both diseases (T1DM: OR = 0.943, 95% CI: 0.898–0.991, .020; COVID-19: 0.919, 0.882–0.958, < .001), suggesting a protective effect against their comorbidity. genetic highlights DSCC1 as potential target monitoring managing co-occurrence COVID-19.

Язык: Английский

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State of Knowledge About Thyroid Cancers in the Era of COVID-19—A Narrative Review

Biomedicines, Год журнала: 2024, Номер 12(12), С. 2829 - 2829

Опубликована: Дек. 13, 2024

Thyroid cancer (TC), due to its heterogeneous nature, remains a clinical challenge. Many factors can initiate the carcinogenesis process of various types TC, which complicates diagnosis and treatment. The presented review gathers current information on specific taking into account effects COVID-19 pandemic. It is likely that has influenced continues influence function thyroid gland. A high percentage patients with showing simultaneous pathological changes in suggests SARS-CoV-2 may disrupt this gland pro-oxidative mechanisms, inflammatory states, autoimmune diseases, thereby promoting formation neoplastic changes. Furthermore, expression ACE2, TMPRSS2, CLEC4M DPP4 genes, observed also occur COVID-19. Therefore, it probable interaction cell receptors Additionally, some drugs used TC therapy (e.g., levothyroxine) increase affinity for cells, could contribute more severe course emergence long-term symptoms (post-COVID-19). Moreover, consequences sanitary restrictions (limited access medical services, reduction endocrinological oncological procedures) took place many countries during pandemic lead future an increased number missed diagnoses aggressive cancers.

Язык: Английский

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Effectiveness of home-based exercise for functional rehabilitation in older adults after hip fracture surgery: A systematic review and meta-analysis of randomized controlled trials

PLoS ONE, Год журнала: 2024, Номер 19(12), С. e0315707 - e0315707

Опубликована: Дек. 19, 2024

This systematic review and meta-analysis was performed to assess effectiveness of home-based exercise compared with control interventions for functional rehabilitation in elderly patients after hip fracture surgery. Comprehensive literature search on PubMed, EMBASE, Web Science, Cochrane library, Clinicaltrails.gov identify eligible randomized controlled trials (RCTs). Standard mean difference (SMD) risk ratio (RR) 95% confidence interval (CI) calculated. The certainty evidence each outcome assessed by using Grading Recommendations Assessment, Development Evaluation (GRADE) approach. A total 28 articles reporting 21 unique RCTs (n = 2470) were finally included. Compared interventions, significantly improved Berg balance scale (BBS, SMD 0.28, 95%CI: 0.03 0.53, P 0.030), timed-up-and-go test (TUG, -0.28, -0.50 -0.07, 0.009), Short Fort-36 physical component score (SF-36 PCS, 0.49, 0.28 0.70, P<0.001), knee extensor strength (SMD 0.23, 0.09 0.37, 0.001). No significant improvement observed gait speed, 6-minute walking test, short performance battery (SPPB), activities daily living (ADL), or fear falling the home group. Risk adverse events, including emergency department visits, hospital readmissions, falls, did not differ between both groups. According GRADE, overall moderate usual SPPB, ADL, falling, SF-36 low very other outcomes. Our demonstrated had positive effect function Home-based might be recommended fractured discharge.

Язык: Английский

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Decarceration and COVID-19 infections in U.S. Immigration and Customs Enforcement detention facilities: a simulation modeling study

The Lancet Regional Health - Americas, Год журнала: 2024, Номер 42, С. 100971 - 100971

Опубликована: Дек. 27, 2024

Язык: Английский

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A Comprehensive Analysis of Risk Factors Associated with Type 1 Diabetes Mellitus in Children and Adolescents at a Tertiary Healthcare Facility

Pakistan Journal of Health Sciences, Год журнала: 2024, Номер unknown, С. 56 - 61

Опубликована: Дек. 31, 2024

Type 1 Diabetes is an autoimmune condition affecting the pancreas. Objectives: To assess associations between genetic and environmental risk factors development of Mellitus in children adolescents. Methods: It was a case-control study conducted over 6 months at Department Pediatric Endocrinology Diabetes, Children’s Hospital Lahore. The population consisted two groups. Cases with while controls were without Diabetes. Data collected using pre-designed questionnaire by interview method from parents participating study. incidence various reported to be associated compared Results: 300 participated (n=150 cases n=150 control group). mean age participants 7.90 + 4.553 years. Pearson chi-square test revealed significant association like cow’s milk infancy, early weaning, vitamin D supplementation. Amongst factors, for history autoimmunity, family autoimmunity (p-value=<0.05). Conclusions: concluded that or self family, introduction supplementary foods are higher Meanwhile, no relationship established prior COVID-19 infection recurrent infections. Further studies needed establish cause effect relationship.

Язык: Английский

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