“If that would have lessened my symptoms, that would have been great...”: a qualitative study about the acceptability of tecovirimat as treatment for mpox

BMC Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 21, 2025

Tecovirimat, an antiviral treatment for smallpox, was approved as a mpox by the European Medicines Agency in January 2022. Approval granted under "exceptional circumstances" based on effectiveness found pre-clinical challenge studies animals and safety humans showing minimal side effects. As clinical efficacy are still ongoing, there is currently limited information with regard to acceptability of tecovirimat treat mpox. The aim this study understand prospective use A co-produced, qualitative, focus group design conducted theoretically informed sample people from communities at higher risk experience illness. Thirteen participants took part: all self-identified cisgender male, 1 Black British, British Asian, 5 White, 3 White Other. Inclusion criteria were follows: illness; age 18 over; living United Kingdom (UK); UK during 2022 outbreak. Focus groups recorded, transcribed thematically analysed using combination inductive deductive coding Treatment Acceptability Framework. Very few aware option none offered it their Key factors influencing levels trust medicine; level information; provider communication approach; quality care. Marginalised highest may have prior structural discrimination which can greatly influence acceptability. This exploratory suggest that offering (or comparable emergency-licensed treatments) acceptable, although uptake will depend knowledge options, medicine medical professionals provision relevant choice. To increase such treatments, clinicians should ensure patients symptom management including pain relief; acknowledge address patient concerns upfront within context non-stigmatising care; communicate offers consistent supportive manner line locally eligibility protocols time.

Язык: Английский

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Prevention of sexual transmission of mpox: a systematic review and qualitative evidence synthesis of approaches

Infectious Diseases, Год журнала: 2024, Номер 56(8), С. 589 - 605

Опубликована: Июль 3, 2024

The ongoing multi-country mpox outbreak in previously unaffected countries is primarily affecting sexual networks of men who have sex with men. Evidence needed on the effectiveness recommended preventive interventions. To inform WHO guidelines, a systematic review and qualitative evidence synthesis were conducted behavioural interventions to reduce: (i) acquisition; (ii) onward transmission from confirmed/probable cases; (iii) utility asymptomatic testing.

Язык: Английский

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Framing the Multi‐Centre Qualitative Research Design as a Novel Methodology for Nursing and Healthcare Research: Reflections and A Methodological Discussion

Journal of Advanced Nursing, Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

ABSTRACT Aim To discuss the multi‐centre qualitative methodology as a unique design, articulate its guiding paradigm/theoretical perspectives, and highlight methodological methodical issues. A secondary objective is to generate further scholarly discourse regarding approach within broader research tradition. Design Methodological discussion. Findings Rather than an emphasis on only experiences, presented design which also focuses uncovering why phenomenon or problem exists perceptions phenomenon/problem. With focus capturing multiple subjective realities, arguably underpinned by pragmatist constructivism offers robust framework for researching in way that both theoretically informed practically relevant. Methodologically, emphasises problem‐centred enquiry, collaborative rigorous study protocols, systematic site selection, contextual immersion sensitivity flexibility. Conclusion rapidly evolving nursing global health landscape, lends itself exploring larger scale compared single studies. Careful planning, availability of adequate resources, protocols quality assurance plans are critical ensuring success. Implications Profession Patient Care The possibility undertaking same across settings/locations has potential improve representation strengthen transferability. Impact This discussion clarity use offering strategies subsequent uptake healthcare research. Reporting Method Not applicable. Public Contribution No patient public contribution.

Язык: Английский

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Negotiating Access to Healthcare and Experience of Stigma Among Cisgender Gay Men Diagnosed with Mpox During the 2022 Epidemic in France: A Qualitative Study

AIDS and Behavior, Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

Язык: Английский

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Intentions of healthcare seeking and self-isolation for MPOX among men who have sex with men in China: a national cross-sectional study

Emerging Microbes & Infections, Год журнала: 2024, Номер 13(1)

Опубликована: Май 7, 2024

Linking identified MPOX cases to care is essential for control. This study aims investigate the intentions of healthcare seeking and self-isolation among men who have sex with (MSM) in China. A cross-sectional online survey was conducted early August 2023 Respondents were recruited by community-based organizations (CBOs), collecting information on demographics, health status, behavioural psychological characteristics. Univariate multivariate logistic regression analyses performed examine predictors seek self-isolate within MSM population. total 7725 participants recruited, a median age 30 years. 92.21% would MPOX-like symptoms, but only 52.50% intended if diagnosed. Intentions lower those symptoms past 3 months (standardized prevalence ratio (SPRs) = 0.82, 95% CI: 0.74-0.89) willingness reduced diagnosed (SPRs 0.65, 0.48-0.87). Participants free sexually transmitted infections (STIs) aware their HIV status more likely than STIs or unaware status. Regular followers perceiving low risk infection inclined take preventive measures. These findings highlight need targeted prevention strategies high-risk groups importance addressing barriers infectious disease response.

Язык: Английский

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Efforts made, challenges faced, and recommendations provided by stakeholders involved in mpox prevention and control in China: a qualitative study

Public Health, Год журнала: 2024, Номер 236, С. 115 - 124

Опубликована: Авг. 24, 2024

Язык: Английский

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