Multicentre case-control study on the association between COVID-19 vaccines and neurological disorders (COVIVAX)

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 4, 2025

The COVIVAX study assessed the association between COVID-19 vaccination and risk of common neurological disorders in a multicenter case-control design. Vaccination exposure was compared individuals with first diagnosis disorder (cases) age- sex-matched controls. A total 624 participants were enrolled, after random 1:1 matching 265 cases matched controls (total 530 participants) included analyses. most frequent stroke (60.4%), multiple sclerosis (11.3%) seizures (6.4%). proportion vaccinated 72.1% among 79.6% protective role on developing new detected unadjusted analysis (OR 0.50; 95% CI 0.29–0.86; p = 0.0114). After adjustment for confounders, number doses received associated reduced aged over 60 years ( 0.0472; OR 0.14, 0.03–0.68), pre-existing comorbidities (p 0.0122; 0.04, 0.01–0.99) 0.0232; 0.02–0.97). provided no warning sign regarding an increase following any type or doses. potentially effect vaccines against people needs to be confirmed by further studies.

Язык: Английский

Potential association between COVID-19 and neurological disorders: analysis of common genes and therapeutics

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Окт. 14, 2024

As the COVID-19 pandemic persists, increasing evidences suggest that patients with may face risks of neurological complications and sequelae. To address this issue, we conducted a comprehensive study aimed at exploring relationship between various disorders, particular focus on shared dysregulated genes potential therapeutic targets. We selected six disorders for investigation, including Alzheimer’s disease, epilepsy, stroke, Parkinson’s sleep disorders. Through bioinformatics analysis association these COVID-19, to uncover common molecular mechanisms treatment pathways. In study, utilized publicly available RNA-Seq microarray datasets, employed tools such as Limma DESeq2 differential gene analysis. Gene Ontology Kyoto Encyclopedia Genes Genomes pathway enrichment analysis, explored biological features Additionally, focused analyzing regulatory roles miRNA transcription factors differentially expressed genes, predicted drugs interacting genes. These analyses contribute better understanding provide theoretical basis future strategies. research, aim offer deeper insights scientific community present new perspectives clinical practice in addressing challenges sequelae faced by patients.

Язык: Английский