Treatment of chronic hepatitis C infection: strategies to address poor therapy adherence

Expert Review of Anti-infective Therapy, Год журнала: 2025, Номер unknown, С. 1 - 9

Опубликована: Март 29, 2025

Introduction Non-adherence to any therapy may be related skipping drug doses, discontinuation of therapy, or loss follow-up. It leads the ineffectiveness treatment, which is associated with obvious individual health losses, significant social and financial costs, and, in case infectious diseases, epidemiological consequences resulting from possibility further spread infection.

Язык: Английский

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The Fight Continues: Virus Without Vaccines

Опубликована: Янв. 1, 2025

Язык: Английский

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Hospitalizations and deaths among people coinfected with HIV and HCV

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 19, 2024

Coinfection with human immunodeficiency virus (HIV) and hepatitis C (HCV) remains a significant public health challenge. This retrospective, population-based study assessed the trends in hospitalization rates among patients co-infected HCV HIV Poland 2012–2022, encompassing COVID-19 pandemic massive influx of war refugees from Ukraine, demographics clinical characteristics hospitalized patients, including in-hospital case fatality rates. Most were over 40 years old (mean ± SD: 41.7 8.9 years) men (74%). The mean annual rate was estimated at 1.33 per 105 three-fold lower period 0.51 105) than pre-pandemic era 1.63 105). In turn, case-fatality increased during (from 1.83 to 3.93) but not women (a 1.53 both periods). There no increase 2022, which inflow Ukraine occurred. epidemiological situation people (co)infected requires further monitoring, though it did escalate studied due Ukraine.

Язык: Английский

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Trends in Hospitalizations of Patients with Hepatitis C Virus in Poland between 2012 and 2022

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(18), С. 5618 - 5618

Опубликована: Сен. 22, 2024

Background: Analyzing hospitalizations of patients with hepatitis C virus (HCV) infection is essential for an effective action plan to eliminate as a public health threat. This study aimed explore trends in HCV and factors related these hospitalizations. Methods: 11-year retrospective (2012–2022) explored Poland based on data from the Nationwide General Hospital Morbidity Study. Results: The mean age individuals was 55 years, hospitalization rates among men women 15.5 13.7 per 100,000 population, respectively. Hospitalizations were 1.8-fold higher urban residents. most frequent comorbidities digestive (24%) cardiovascular (18%) diseases. During studied period, significantly decreased 31.9 2012 5.0 2022, stays requiring 0–3, 4–7, ≥8 days becoming 8-fold, 6-fold, 4-fold less frequent, flattening apparent across all groups, including children. Conclusions: While significant progress has been made managing Poland, continued efforts are required disparities care sustain momentum toward elimination, particularly through enhanced political commitment implementation comprehensive national screening programs.

Язык: Английский

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Early evolution of mumps-HCV chimeric viruses in Vero cells induces loss of HCV gene expression and promotes accumulation of substitutions uncharacteristic of mumps strains

Virology, Год журнала: 2024, Номер 603, С. 110379 - 110379

Опубликована: Дек. 25, 2024

Язык: Английский

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