Frontiers in Pediatrics,
Год журнала:
2022,
Номер
10
Опубликована: Март 7, 2022
The
volume
and
breadth
of
research
on
the
role
microbiome
in
neurodevelopmental
neuropsychiatric
disorders
has
expanded
greatly
over
last
decade,
opening
doors
to
new
models
mechanisms
gut-brain
axis
therapeutic
interventions
reduce
burden
these
outcomes.
Studies
have
highlighted
window
birth
3
years
as
an
especially
sensitive
when
may
be
most
effective.
Harnessing
powerful
during
this
critical
developmental
clarifies
important
investigations
into
microbe-human
connection
developing
brain,
affording
opportunities
prevent
rather
than
treat
illness.
In
review,
we
present
overview
intestinal
age
3;
its
prospective
relationship
with
neurodevelopment,
particular
emphasis
immunological
mechanisms.
Next,
neurobehavioral
outcomes
(such
autism,
anxiety,
attention-deficit
hyperactivity
disorder)
well
cognitive
development
are
described.
sections,
highlight
importance
pairing
mechanistic
studies
murine
large
scale
epidemiological
that
aim
clarify
typical
health
promoting
early
life
across
varied
populations
comparison
dysbiosis.
is
focus
human
because
it
so
readily
alterable
simple
interventions,
briefly
outline
what
known
about
targeted
More
novel
examinations
environmental
chemicals
adversely
impact
potential
a
mediator
or
modifier
discussed.
Finally,
look
future
emphasize
need
for
additional
identify
alterations
their
gut
how
might
correct
optimize
Frontiers in Cellular Neuroscience,
Год журнала:
2021,
Номер
14
Опубликована: Янв. 15, 2021
Providing
the
appropriate
quantity
and
quality
of
food
needed
for
both
mother’s
well-being
healthy
development
offspring
is
crucial
during
pregnancy.
However,
macro-
micronutrient
intake
also
impacts
body’s
regulatory
supersystems
mother,
such
as
immune,
endocrine,
nervous
systems,
which
ultimately
influence
overall
offspring.
Of
particular
importance
association
between
unhealthy
maternal
diet
neurodevelopmental
disorders
in
Epidemiological
studies
have
linked
like
autism
spectrum
disorders,
attention-deficit-hyperactivity
disorder,
schizophrenia,
to
immune
activation
(MIA)
gestation.
While
deleterious
consequences
diet-induced
MIA
on
neurodevelopment
are
increasingly
revealed,
neuroinflammation
emerging
a
key
underlying
mechanism.
In
this
review,
we
compile
evidence
available
how
mother
impacted
by
dietary
imbalance.
We
specifically
explore
various
inflammatory
anti-inflammatory
effects
components
discuss
changes
status
can
prime
brain
toward
disorders.
Lastly,
research
mechanisms
that
sustain
relationship
imbalance
development,
involving
altered
neuroinflammatory
offspring,
well
genetic
cellular
programming
notably
microglia,
gut
microbiome
may
act
mediator.
Frontiers in Pediatrics,
Год журнала:
2022,
Номер
10
Опубликована: Март 7, 2022
The
volume
and
breadth
of
research
on
the
role
microbiome
in
neurodevelopmental
neuropsychiatric
disorders
has
expanded
greatly
over
last
decade,
opening
doors
to
new
models
mechanisms
gut-brain
axis
therapeutic
interventions
reduce
burden
these
outcomes.
Studies
have
highlighted
window
birth
3
years
as
an
especially
sensitive
when
may
be
most
effective.
Harnessing
powerful
during
this
critical
developmental
clarifies
important
investigations
into
microbe-human
connection
developing
brain,
affording
opportunities
prevent
rather
than
treat
illness.
In
review,
we
present
overview
intestinal
age
3;
its
prospective
relationship
with
neurodevelopment,
particular
emphasis
immunological
mechanisms.
Next,
neurobehavioral
outcomes
(such
autism,
anxiety,
attention-deficit
hyperactivity
disorder)
well
cognitive
development
are
described.
sections,
highlight
importance
pairing
mechanistic
studies
murine
large
scale
epidemiological
that
aim
clarify
typical
health
promoting
early
life
across
varied
populations
comparison
dysbiosis.
is
focus
human
because
it
so
readily
alterable
simple
interventions,
briefly
outline
what
known
about
targeted
More
novel
examinations
environmental
chemicals
adversely
impact
potential
a
mediator
or
modifier
discussed.
Finally,
look
future
emphasize
need
for
additional
identify
alterations
their
gut
how
might
correct
optimize
