Therapeutic Potential Effect of Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors in Parkinson Disease: Exploring an Overlooked Avenue

Molecular Neurobiology, Год журнала: 2024, Номер 61(9), С. 7092 - 7108

Опубликована: Фев. 17, 2024

Abstract Parkinson’s disease (PD) is a progressive neurodegenerative of the brain due to degeneration dopaminergic neurons in substantia nigra (SN). Glycogen synthase kinase 3 beta (GSK-3β) implicated pathogenesis PD. Therefore, purpose present review was revise mechanistic role GSK-3β PD neuropathology, and how inhibitors affect neuropathology. GSK-3 conserved threonine/serine protein that intricate regulation cellular anabolic catabolic pathways by modulating glycogen synthase. Over-expression also interconnected with development different diseases. However, underlying mechanism neuropathology not fully clarified. induces triggering mitochondrial dysfunction oxidative stress SN. NF-κB NLRP3 inflammasome are activated response dysregulated leading neuronal injury. Higher expression early stages might contribute reduction neuroprotective brain-derived neurotrophic factor (BDNF). Thus, may be effective reducing inflammatory disorders which associated

Язык: Английский

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The classical and non-classical axes of renin-angiotensin system in Parkinson disease: The bright and dark side of the moon

Ageing Research Reviews, Год журнала: 2024, Номер 94, С. 102200 - 102200

Опубликована: Янв. 17, 2024

Язык: Английский

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Controversial Properties of Amyloidogenic Proteins and Peptides: New Data in the COVID Era

Biomedicines, Год журнала: 2023, Номер 11(4), С. 1215 - 1215

Опубликована: Апрель 19, 2023

For a long time, studies of amyloidogenic proteins and peptides (amyloidogenic PPs) have been focused basically on their harmful properties association with diseases. A vast amount research has investigated the structure pathogenic amyloids forming fibrous deposits within or around cells mechanisms detrimental actions. Much less known about physiologic functions beneficial PPs. At same PPs various useful properties. example, they may render neurons resistant to viral infection propagation stimulate autophagy. We discuss here some PPs’ using as examples beta-amyloid (β-amyloid), implicated in pathogenesis Alzheimer’s disease (AD), α-synuclein—one hallmarks Parkinson’s (PD). Recently antiviral antimicrobial attracted attention because COVID-19 pandemic growing threat other bacterial-induced Importantly, several proteins, e.g., spike, nucleocapsid, envelope become after combine action effect endogenous APPs. central area current investigations is study structural PPs, defining properties, identifying triggers that transform physiologically important into vicious substances. These directions are paramount importance during SARS-CoV-2 global health crisis.

Язык: Английский

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The potential role of brain renin‐angiotensin system in the neuropathology of Parkinson disease: Friend, foe or turncoat?

Journal of Cellular and Molecular Medicine, Год журнала: 2024, Номер 28(12)

Опубликована: Июнь 1, 2024

Abstract Parkinson disease (PD) is one of the most common neurodegenerative diseases brain. Of note, brain renin‐angiotensin system (RAS) intricate in PD neuropathology through modulation oxidative stress, mitochondrial dysfunction and neuroinflammation. Therefore, RAS by angiotensin receptor blockers (ARBs) angiotensin‐converting enzyme inhibitors (ACEIs) may be effective reducing risk neuropathology. It has been shown that all components including peptides enzymes are present different areas. Brain plays a critical role regulation memory cognitive function, controlling central blood pressure. However, exaggerated implicated pathogenesis PD. Two well‐known pathways recognized including; classical pathway which mainly mediated AngII/AT1R detrimental effects. Conversely, non‐classical mostly ACE2/Ang1‐7/MASR AngII/AT2R beneficial effects against Exaggerated affects viability dopaminergic neurons. fundamental mechanism was not fully elucidated. Consequently, purpose this review to disclose mechanistic In addition, we try revise how ACEIs ARBs can developed for therapeutics

Язык: Английский

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Microglial Inflammatory Responses to SARS‐CoV‐2 Infection: A Comprehensive Review

Cellular and Molecular Neurobiology, Год журнала: 2023, Номер 44(1)

Опубликована: Дек. 15, 2023

Язык: Английский

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Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition

Journal of the Neurological Sciences, Год журнала: 2023, Номер 454, С. 120827 - 120827

Опубликована: Окт. 13, 2023

Язык: Английский

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Dysregulation of serotonergic neurotransmission in Parkinson disease: A key duet

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177419 - 177419

Опубликована: Фев. 1, 2025

Язык: Английский

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Intracellular Alterations, Vacuolization and Bypass mechanism by SARS-CoV-2 Infection could be the Possible Basis of Respiratory Distress and Hypoxia

Tissue and Cell, Год журнала: 2025, Номер unknown, С. 102896 - 102896

Опубликована: Март 1, 2025

Язык: Английский

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Neuroprotective Effect Of Thymus Vulgaris On Paraquat Induced Parkinson’s Disease

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер unknown, С. 151740 - 151740

Опубликована: Апрель 1, 2025

Язык: Английский

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Chenodeoxycholic Acid-Mediated neuroprotection via α-synuclein and BDNF Modulation in MPTP-Induced mouse model of Parkinson’s disease

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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