Journal of Inflammation Research,
Год журнала:
2023,
Номер
Volume 16, С. 4471 - 4479
Опубликована: Окт. 1, 2023
Peri-implantitis
is
an
important
cause
of
oral
implant
failure.
In
the
past,
TLR4
and
TLR2
in
Toll-like
family
were
generally
considered
as
key
immune
recognition
receptors
regulating
peri-implantitis.
However,
under
guidance
this
theory,
there
are
still
some
unexplainable
peri-implantitis
symptoms.
With
discovery
novel
intracellular
LPS
receptor
Caspase-11,
a
new
understanding
inflammatory
signaling
regulation
development
has
been
gained.
regulatory
role
Caspase-11
its
crosstalk
with
pathway
remain
unclear.
The
therapeutic
effect
drugs
targeting
on
early
stages.
view
situation,
paper
reviews
possible
peri-implant
inflammation,
elaborated
entry
process
activation
mechanism
analyzes
differences
between
commonly
studied
animals,
mice
humans.
current
research
hotspots
challenges
also
analyzed
to
provide
insights
ideas
for
researchers.
Ageing Research Reviews,
Год журнала:
2024,
Номер
99, С. 102360 - 102360
Опубликована: Май 29, 2024
This
article
brings
a
new
perspective
on
oral
physiology
by
presenting
the
organ
as
an
integrated
entity
within
entire
organism
and
its
surrounding
environment.
Rather
than
considering
mouth
solely
collection
of
discrete
functions,
this
novel
approach
emphasizes
role
dynamic
interphase,
supporting
interactions
between
body
external
factors.
As
resilient
ecosystem,
equilibrium
ecological
niches
is
result
large
number
interconnected
factors
including
heterogeneity
different
structures,
diversity
resources,
internal
pressures
biological
actors.
The
manuscript
seeks
to
deepen
understanding
age-related
changes
cavity
throughout
organism,
aligning
with
evolving
field
gerophysiology.
strategic
position
fundamental
function
make
it
invaluable
target
for
early
prevention,
diagnosis,
treatment,
even
reversal
aging
effects
organism.
Recognizing
capacity
sensory
perception,
element
capture
information
processing
underscores
vital
in
continuous
health
monitoring.
Overall,
aims
at
advancing
comprehensive
approaches
healthcare
promoting
broader
awareness
implications
overall
well-being.
Abstract
The
present
study
aims
to
investigate
the
role
of
interferon
regulatory
factor
4
(IRF4)
in
osteogenic
differentiation
periodontal
ligament
stem
cells
(PDLSCs)
and
analyze
underlying
signaling
these
processes.
In
this
study,
IRF4
is
upregulated
periodontitis
tissues,
as
compared
healthy
tissues.
knockdown
increases
cell
proliferation,
decreases
levels
tumor
necrosis
factor‐alpha,
interleukin‐6,
interleukin‐8,
enhances
activity,
expression
RUNX
family
transcription
2,
Collagen
I,
Osteocalcin
PDLSCs.
opposite
results
are
observed
overexpressed
Additionally,
GSEA
shows
that
activates
interleukin‐18
(IL‐18)
pathway.
expressions
IL‐18,
B‐cell
translocation
gene
interleukin‐1beta,
caspase‐3
decreased
by
knockdown,
while
increased
overexpression.
IL‐18
overexpression
eliminates
promoting
effect
on
conclusion,
suppresses
PDLSCs
activating
Introduction
Periodontitis
is
a
multifactorial
oral
disease
causing
destruction
of
the
periodontium.
Systemic
diseases
can
exacerbate
periodontal
inflammation
through
immune
dysregulation.
N-terminal-probrain
natriuretic
peptide
(NT-proBNP)
prohormone,
released
by
myocardial
cells
known
biomarker
for
cardiovascular
(CVD).
Existing
literature
discloses
bidirectional
relationship
between
periodontitis
and
CVD.
NT-proBNP
release
be
regulated
mediators
systemic
inflammation.
Cardiocyte
might
get
stimulated
proinflammatory
cytokines.
levels
also
influenced
in
absence
cardiac
dysfunction.
Accordingly,
we
postulated
that
periodontium
could
aid
increased
serum
saliva
participants
without
disorders.
Saliva
said
to
mirror
body.
Assessing
NT-pro
BNP
allows
non-invasive
method.
The
present
research
evaluated
salivary
concentrations
healthy
group,
patients
suffering
from
along
with
infarction
(MI).
Material
method
A
total
90
patients,
30
each
group
i.e.,
infarction,
were
enrolled.
selected
according
Classification
Periodontal
Peri-implant
Diseases
Conditions
2017.
Patients
clinically
diagnosed
MI
physician
following
World
Health
Organization
criteria
detection
MI.
Case
history
was
recorded
parameter
analysis
like
plaque
index
(PI),
gingival
(GI),
probing
pocket
depth
(PPD)
clinical
attachment
loss
(CAL)
measured.
Salivary
samples
collected
after
obtaining
informed
consent.
subjected
human
sandwich
type
enzyme-linked
immunosorbent
assay
(ELISA)
quantitative
evaluation.
obtained
data
analysed
compared
using
ANOVA,
Tukey's
post
hoc
test
Pearson's
correlation.
p-value<0.05
considered
statistically
significant.
Result
PI
GI
highest
subjects
only
(p<0.05).
exhibited
significantly
higher
PPD
CAL
values
p-value=0.000
than
patients.
1.570
pg/mL
1.694
saliva.
Conclusion
affected
Elevated
due
stress
linking
positive
correlation
parameters
validates
biomarker's
role
reflecting
extent
its
association
stress.
used
as
diagnostic
marker
diagnosing
Future
explore
targeted
therapies
shared
inflammatory
pathways
Journal of Inflammation Research,
Год журнала:
2023,
Номер
Volume 16, С. 4471 - 4479
Опубликована: Окт. 1, 2023
Peri-implantitis
is
an
important
cause
of
oral
implant
failure.
In
the
past,
TLR4
and
TLR2
in
Toll-like
family
were
generally
considered
as
key
immune
recognition
receptors
regulating
peri-implantitis.
However,
under
guidance
this
theory,
there
are
still
some
unexplainable
peri-implantitis
symptoms.
With
discovery
novel
intracellular
LPS
receptor
Caspase-11,
a
new
understanding
inflammatory
signaling
regulation
development
has
been
gained.
regulatory
role
Caspase-11
its
crosstalk
with
pathway
remain
unclear.
The
therapeutic
effect
drugs
targeting
on
early
stages.
view
situation,
paper
reviews
possible
peri-implant
inflammation,
elaborated
entry
process
activation
mechanism
analyzes
differences
between
commonly
studied
animals,
mice
humans.
current
research
hotspots
challenges
also
analyzed
to
provide
insights
ideas
for
researchers.
