Macrophages Unmasked: Their Pivotal Role in Driving Atherosclerosis in Systemic Lupus Erythematosus

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Фев. 7, 2025

Язык: Английский

Exploring the Relationship Between Immune Cells and Chronic Kidney Disease by Mendelian Randomization, Colocalization Analysis, and SMR

Mediators of Inflammation, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Background: Chronic kidney disease (CKD) impacts millions of individuals annually. Current research suggests that immune factors played a significant role in CKD. However, the potential causal relationship between them remains unclear. Methods: We conducted comprehensive Mendelian randomization (MR) analysis to assess association 731 cells and Sensitivity was performed test for heterogeneity horizontal pleiotropy, including Cochran Q test, leave‐one‐out MR‐Egger intercept analysis, MR‐PRESSO test. The bidirectional MR utilized investigate Multivariable also mitigate confounding among cells. colocalization find key genes used Summary data‐based (SMR) generate effect estimates cis‐eQTL dependent instruments (HEIDIs) instrumental variables. Results: identified 14 pathogenic six protective through univariable MR. Moreover, we did not reverse causation by using finally one risk factor two after multivariate adjustment effects CD28 on + CD45RA CD8 T cell could increase CKD (Pval: 0.033, OR: 1.112, 95% CI: 1.009–1.227). CD11c myeloid dendritic (DC) decrease 0.02, 0.854, 0.748–0.975). naive CD4 0.026, 0.918, 0.852–0.990). Importantly, observed no evidence signifying robustness our results. BACH2 (PPH4.abf = 0.999, P_SMR: <0.001, P_HIEDI: 0.132) HLA-G 0.990, 0.141) shared same variant with cell. PAQR9 0.992, 0.215) DC. Conclusion: correlation Colocalization SMR found Our findings offer insights into prevention management further investigation is required elucidate precise mechanisms underlying this relationship.

Язык: Английский

Association Between Autoimmune Thyroid disease and Oral Lichen Planus: A Multi-Omic Genetic Analysis

International Dental Journal, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский