Journal of Liquid Chromatography & Related Technologies,
Год журнала:
2023,
Номер
47(1-5), С. 1 - 13
Опубликована: Дек. 27, 2023
Qingwei
Huanglian
Wan
(QHW)
is
a
traditional
Chinese
medicine
used
for
treating
inflammation.
As
the
compositions
of
QHW
preparations
are
complex
and
varied,
it
has
proven
difficult
to
identify
active
ingredients
in
control
quality.
In
this
study,
high-performance
liquid
chromatography
(HPLC)
fingerprints,
network
pharmacology,
molecular
docking,
Griess
method
were
screen
verify
potential
QHW.
First,
sixteen
batches
studied
as
two
groups
using
multivariate
statistical
analysis.
Thirteen
peaks
detected
HPLC
results
establish
fingerprint
similarity
model,
six
chemical
constituents
(phellodendrine
hydrochloride,
geniposide,
berberine
baicalin,
wogonoside,
glycyrrhizic
acid)
identified.
Among
these
constituents,
four
components
(glycyrrhizic
acid,
wogonoside)
considered
ingredients.
Second,
further
elucidate
There
was
no
significant
difference
NO
content
administration
group
(dose
converted
into
medium-dose
group)
group.
Then,
contents
acid
determined
method.
This
study
provides
comprehensive
reliable
strategy
quality
identifies
Our
methodology
may
also
be
useful
studying
other
medicines.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 31, 2023
The
World
Health
Organization
declared
that
COVID-19
is
no
longer
a
public
health
emergency
of
global
concern
on
May
5,
2023.
Post-COVID
disorders
are,
however,
becoming
more
common.
Hence,
there
lies
growing
need
to
develop
safe
and
effective
treatment
measures
manage
post-COVID
disorders.
Investigating
the
use
TCM
medicinal
foods
in
long-term
therapy
illnesses
may
be
beneficial
given
contemporary
research's
emphasis
development
foods.The
for
highlighted
this
review.
Following
discussion
history
"Medicine
Food
Homology"
theory,
pathophysiological
effects
will
briefly
reviewed.
An
analysis
their
functions
treating
then
provided
before
offering
some
insight
into
potential
directions
future
research
application.TCM
can
different
aspects
management
efficient
choice
because
they
are
typically
milder
nature
than
chronic
drug
use.
These
findings
also
applied
post-disease
similar
respiratory
Journal of Traditional and Complementary Medicine,
Год журнала:
2024,
Номер
15(2), С. 107 - 118
Опубликована: Июнь 22, 2024
Cardiotoxicity
refers
to
the
damage
caused
heart
or
vascular
system,
which
has
become
a
significant
cause
of
morbidity
and
mortality
worldwide.
Up
20
%
adults
undergoing
cancer
treatment
may
experience
cardiotoxicity,
with
7
%-10
developing
cardiomyopathy
failure.
Cardiotoxic
medications
put
patients
at
risk
for
variety
conditions,
including
cardiac
failure
(HF),
left
ventricle
(LV)
systolic
malfunction,
arrhythmia,
hypertension,
coronary
artery
disease
(CAD),
ischemia/myocardial
infarction.
These
diseases
significantly
impact
patient's
quality
life
outcomes.
Many
conventional
chemotherapy
agents
have
serious
adverse
effects.
Anthracyclines,
alkylating
agents,
taxanes,
topoisomerase
inhibitors,
antimetabolites
are
chemotherapeutic
that
induce
cardiotoxicity.
Recently,
there
been
an
increasing
focus
on
using
traditional
Chinese
medicine
(TCM)
treat
chemotherapy-induced
TCM
encompasses
range
practices,
such
as
herbology,
acupuncture,
dietary
therapy,
physical
exercises
like
t'ai
chi.
practices
aim
enhance
flow
qi,
can
alleviate
symptoms
illness.
Although
effectiveness
not
extensively
researched
supported,
scientists
begun
utilizing
scientific
methods
gain
deeper
understanding
mechanisms
underlying
TCM.
Ongoing
research
is
being
conducted
determine
safety
treatments
in
reducing
toxicity.
The
present
study
aims
evaluate
protection
efficacy
various
Bioscience of Microbiota Food and Health,
Год журнала:
2024,
Номер
43(3), С. 150 - 161
Опубликована: Янв. 1, 2024
Type
1
diabetes
(T1D)
is
a
specific
autoimmune
disease
related
to
genetic
and
factors.
Recent
studies
have
found
that
the
intestinal
flora
one
of
important
environmental
factors
in
development
T1D.
The
gut
microbiota
largest
human
body
has
significant
impact
on
material
energy
metabolism.
Related
floras
T1D
patients
are
unbalanced.
Compared
with
normal
patients,
abundance
beneficial
bacteria
reduced,
various
pathogenic
significantly
increased,
affecting
occurrence
diabetes.
Medicinal
food
homologous
traditional
Chinese
medicine
(TCM)
multicomponent,
multitarget,
biphasic
regulatory
effect.
Its
chemical
composition
can
increase
bacteria,
improve
diversity
flora,
reduce
blood
sugar,
achieve
purpose
preventing
treating
by
regulating
its
metabolites.
Therefore,
based
review
T1D,
TCM
derived
from
food,
this
describes
relationship
between
as
well
research
progress
interventions
for
through
regulation
flora.
Medicine
certain
advantages
It
be
seen
there
still
great
space
broad
prospects
treatment
drug
TCM.
Current Pharmaceutical Design,
Год журнала:
2024,
Номер
30(34), С. 2718 - 2735
Опубликована: Июль 30, 2024
Background:
Oral
mucositis
is
the
most
common
and
troublesome
complication
for
cancer
patients
receiving
radiotherapy
or
chemotherapy.
Recent
research
has
shown
that
Lycium
barbarum,
an
important
economic
crop
widely
grown
in
China,
epithelial
protective
effects
several
other
organs.
However,
it
unknown
whether
not
barbarum
can
exert
a
beneficial
effect
on
oral
mucositis.
Network
pharmacology
been
suggested
to
be
applied
“multi-component-multi-target”
functional
food
studies.
The
purpose
of
this
study
evaluate
through
network
pharmacology,
molecular
docking
experimental
validation.
Aims:
To
explore
biological
mechanisms
treatment
combined
with
Methods:
Based
methods,
we
collected
active
components
related
targets
from
public
databases,
as
well
We
mapped
protein-
protein
interaction
(PPI)
networks,
performed
gene
ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
enrichment,
constructed
'components-disease-targets'
'components-
pathways-targets'
using
Cytoscape
further
analyse
intrinsic
against
affinity
stability
predictions
were
strategies,
experiments
conducted
demonstrate
possible
Results:
A
was
established
between
49
61
OM
targets.
main
compounds
quercetin,
beta-carotene,
palmatine,
cyanin.
predicted
core
IL-6,
RELA,
TP53,
TNF,
IL10,
CTNNB1,
AKT1,
CDKN1A,
HIF1A
MYC.
enrichment
analysis
therapeutic
mainly
regulation
inflammation,
apoptosis,
hypoxia
response
involvement
TNF
HIF
pathways.
Molecular
results
showed
key
bind
In
both
chemically
radiation-induced
models,
significantly
promoted
healing
reduced
inflammation.
verification
targeted
genes
(IL-6,
HIF1A,
MYC)
regulating
signaling
pathways,
which
validated
RT-qPCR,
immunofluorescence
staining
western
blotting
assays.
Conclusion:
conclusion,
present
systematically
demonstrated
could
promote
reduce
inflammatory
Foods,
Год журнала:
2024,
Номер
13(23), С. 3805 - 3805
Опубликована: Ноя. 26, 2024
Umami
peptides
have
the
ability
to
enhance
food
flavours
and
potential
health
benefits.
The
objective
of
this
study
was
conduct
a
comprehensive
investigation
into
umami
intensity,
taste
mechanism,
antioxidant
activity
six
derived
from
wheat
gluten
hydrolysates
(WGHs)
fermented
WGHs.
e-tongue
analysis
demonstrated
that
exhibited
direct
proportionality
in
terms
value
concentration,
were
capable
enhancing
commercially
available
condiments.
molecular
dynamics
simulations
interacted
with
T1R1/T1R3
receptors
via
hydrogen
bonds,
hydrophobic
interactions,
ionic
water
bridges,
thereby
producing
umami.
Furthermore,
DPPH,
ABTS,
hydroxyl
radical-scavenging,
FRAP
assays
vitro.
Ultimately,
network
pharmacology
docking
results
indicated
AKT1,
JUN,
CASP3
may
serve
as
core
targets
for
treatment
oxidative
diseases.
In
conclusion,
work
offers
novel
insights
use
bioactive
peptides,
emphasising
their
prospective
applications
supplement
industries.
Food Science of Animal Products,
Год журнала:
2023,
Номер
1(4), С. 9240041 - 9240041
Опубликована: Дек. 1, 2023
Mizuhopecten
yessoensis-derived
angiotensin
converting
enzyme
(ACE)
inhibitory
peptide
Asn-Cys-Trp
(NCW)
has
been
found
that
had
a
significantly
in
vivo
antihypertensive
effect.
However,
the
special
mechanism
of
NCW
for
lowing
blood
pressure
not
fully
elucidated.
This
study
aimed
to
screen
key
targets
and
elucidate
based
on
network
pharmacology
molecular
docking.
A
total
70
potential
were
identified,
which
mainly
enriched
in
Regulation
pressure,
Positive
regulation
smooth
muscle
cell
proliferation,
other
biological
processes;
Plasma
membrane,
Extracellular
exosome,
cellular
components;
Endopeptidase
activity,
Zinc
ion
binding,
functions.
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
analysis
showed
lipid
atherosclerosis
pathway,
relaxin
signaling
mitogen-activated
protein
kinase
(MAPK)
pathways
regulate
targets.
Eleven
screened
via
topology
interaction
network,
i.e.,
albumin
(ALB),
matrix
metallopeptidase
9
(MMP9),
MMP2,
insulin
like
growth
factor
1,
AKT
serine/threonine
1
(IGF1),
ACE,
nitric
oxide
synthase
3
(NOS3),
peroxisome
proliferator
activated
receptor
gamma
(PPARG),
epidermal
(EGFR),
catalase
(CAT),
renin
(REN).
In
addition,
docking
results
high
affinities
with
these
targets,
hydrogen
bonds
forces
between
provided
theoretical
basis
multi-target
multi-pathway
prevention
improvement
hypertension
NCW.
Natural Resources for Human Health,
Год журнала:
2023,
Номер
3(4), С. 469 - 476
Опубликована: Ноя. 21, 2023
Cardiovascular
death
remains
the
top
causes
of
death,
and
one
main
risk
factors
associated
with
cardiovascular
diseases
are
Atherosclerosis
Type
2
Diabetes
Mellitus.
The
conspiracy
was
high
because
failure
complete
regulatory
network
rather
than
a
single
gene
or
protein
malfunction,
so
one-target
drug
fails
for
eradication
disease.
Natural
compounds
had
potency
to
act
upon
various
targets
elucidate
therapeutic
effects.
In
traditional
medicines,
<i>Nelumbinis
semen</i>
lotus
seeds
were
used
in
treating
multiple
as
functional
food.
world
discovery,
idea
creating
multi-target
medications
against
complicated
conditions
is
gaining
momentum.
To
understand
mechanism
emphasized
by
effect
Nelumbinis
semen
seeds,
which
cumulative
activity
bioactive
components
their
obtained,
common
atherosclerosis
type
diabetes
mellitus
taken.
constructed
using
Cytoscape
3.9.1
software.
protein-protein
interaction
analysed
STRING
database.
Gene
pathway
enrichment
performed
ShinyGo
0.77
no
genes
involved
studied.
active
seed
Myricetin,
Quercetin,
Isofucosterol,
Rhamnetin,
Myristic
acid,
etc.
PPARα,
INSR,
HMGCR
NCp1L1.
key
biological
pathways
compound
elucidates
effects
Diabetic
cardiomyopathy
Terpenoid
backbone
biosynthesis.
Journal of Liquid Chromatography & Related Technologies,
Год журнала:
2023,
Номер
47(1-5), С. 1 - 13
Опубликована: Дек. 27, 2023
Qingwei
Huanglian
Wan
(QHW)
is
a
traditional
Chinese
medicine
used
for
treating
inflammation.
As
the
compositions
of
QHW
preparations
are
complex
and
varied,
it
has
proven
difficult
to
identify
active
ingredients
in
control
quality.
In
this
study,
high-performance
liquid
chromatography
(HPLC)
fingerprints,
network
pharmacology,
molecular
docking,
Griess
method
were
screen
verify
potential
QHW.
First,
sixteen
batches
studied
as
two
groups
using
multivariate
statistical
analysis.
Thirteen
peaks
detected
HPLC
results
establish
fingerprint
similarity
model,
six
chemical
constituents
(phellodendrine
hydrochloride,
geniposide,
berberine
baicalin,
wogonoside,
glycyrrhizic
acid)
identified.
Among
these
constituents,
four
components
(glycyrrhizic
acid,
wogonoside)
considered
ingredients.
Second,
further
elucidate
There
was
no
significant
difference
NO
content
administration
group
(dose
converted
into
medium-dose
group)
group.
Then,
contents
acid
determined
method.
This
study
provides
comprehensive
reliable
strategy
quality
identifies
Our
methodology
may
also
be
useful
studying
other
medicines.
