Evaluation of folic acid-targeted gadolinium-loaded perfluorohexane nanodroplets on the megavoltage X-ray treatment efficiency of liver cancer DOI Creative Commons
Roghayeh Kamran Samani, Masoud A. Mehrgardi, Fatemeh Maghsoudinia

и другие.

European Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 107059 - 107059

Опубликована: Март 1, 2025

The efficacy of radiation therapy can decrease due to the inherent radioresistance different tumor cells. Gadolinium shows significant potential as a radiosensitivity enhancer its high atomic number. In this study, novel theranostic nanoprobe based on folic acid-conjugated gadolinium-loaded nanodroplets (FA-Gd-NDs) has been introduced for ultrasound imaging (USI)-guided hepatocellular carcinoma. echogenicity evaluation NDs, Gd release studies, biocompatibility test Gd-NDs, colony assay, cellular uptake NDs via fluorescence microscopy, and flow cytometry analysis were performed Hepa1-6 cancer L929 normal cell lines. Our results showed that synthesized significantly enhanced signal intensity in PBS solution agarose gel phantom. MTT clonogenic assays indicated Gd-NDs substantially reduced viability also surviving fraction cells under US X-ray exposure. Additionally, FA-Gd-NDs exhibited sensitization enhancement factor (SER) 1.8 after concurrent exposure X-ray. Fluorescence demonstrated more internalization into comparison with According results, by line 20% 28%, respectively, while their was 60% 94%, respectively. conclusion, great enhancing enabling image-guided cancers.

Язык: Английский

Evaluation of folic acid-targeted gadolinium-loaded perfluorohexane nanodroplets on the megavoltage X-ray treatment efficiency of liver cancer DOI Creative Commons
Roghayeh Kamran Samani, Masoud A. Mehrgardi, Fatemeh Maghsoudinia

и другие.

European Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 107059 - 107059

Опубликована: Март 1, 2025

The efficacy of radiation therapy can decrease due to the inherent radioresistance different tumor cells. Gadolinium shows significant potential as a radiosensitivity enhancer its high atomic number. In this study, novel theranostic nanoprobe based on folic acid-conjugated gadolinium-loaded nanodroplets (FA-Gd-NDs) has been introduced for ultrasound imaging (USI)-guided hepatocellular carcinoma. echogenicity evaluation NDs, Gd release studies, biocompatibility test Gd-NDs, colony assay, cellular uptake NDs via fluorescence microscopy, and flow cytometry analysis were performed Hepa1-6 cancer L929 normal cell lines. Our results showed that synthesized significantly enhanced signal intensity in PBS solution agarose gel phantom. MTT clonogenic assays indicated Gd-NDs substantially reduced viability also surviving fraction cells under US X-ray exposure. Additionally, FA-Gd-NDs exhibited sensitization enhancement factor (SER) 1.8 after concurrent exposure X-ray. Fluorescence demonstrated more internalization into comparison with According results, by line 20% 28%, respectively, while their was 60% 94%, respectively. conclusion, great enhancing enabling image-guided cancers.

Язык: Английский

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