Mechanisms and applications of the regenerative capacity of platelets-based therapy in knee osteoarthritis

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117226 - 117226

Опубликована: Июль 29, 2024

Osteoarthritis (OA) is the most prevalent joint disease in elderly population and its substantial morbidity disability impose a heavy economic burden on patients society. Knee osteoarthritis (KOA) common subtype of OA, which characterized by damage to progressive articular cartilage, synovitis, subchondral bone sclerosis. Most current treatments for OA are palliative, primarily aim at symptom management, do not prevent progression or restore degraded cartilage. The activation α-granules platelets releases various growth factors that involved multiple stages tissue repair, suggesting potential modification. In recent years, platelet-based therapies, such as platelet-rich plasma, fibrin, platelet lysates, have emerged promising regenerative KOA, but their related effects mechanisms still unclear. Therefore, this review aims summarize biological characteristics functions platelets, classify products therapy preparation methods. Moreover, we basic research regeneration strategies KOA discuss cellular molecular mechanisms. Further, describe general clinical application treatment results meta-analysis randomized controlled trials.

Язык: Английский

Matrix‐assisted autologous chondrocyte transplantation is effective at mid/long‐term for knee lesions: A systematic review and meta‐analysis

Knee Surgery Sports Traumatology Arthroscopy, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

Язык: Английский