Journal of Controlled Release,
Год журнала:
2024,
Номер
368, С. 703 - 727
Опубликована: Март 19, 2024
Drug
delivery
platforms
have
gracefully
emerged
as
an
indispensable
component
of
novel
cancer
chemotherapy,
bestowing
targeted
drug
distribution,
elevating
therapeutic
effects,
and
reducing
the
burden
unwanted
side
effects.
In
this
context,
hybrid
systems
artfully
harnessing
virtues
liposomes
hydrogels
bring
remarkable
benefits,
especially
for
localized
therapy,
including
intensified
stability,
excellent
amenability
to
hydrophobic
hydrophilic
medications,
controlled
liberation
behavior,
appropriate
mucoadhesion
mucopenetration
shift.
Moreover,
three-dimensional
biocompatible
liposome-integrated
hydrogel
networks
attracted
unprecedented
interest
in
tissue
regeneration,
given
their
tunable
architecture
physicochemical
properties,
well
enhanced
mechanical
support.
This
review
elucidates
presents
cutting-edge
developments
recruiting
treatment
regeneration.
Giant,
Год журнала:
2024,
Номер
19, С. 100323 - 100323
Опубликована: Июль 10, 2024
Inspired
by
the
extracellular
matrix
(ECM),
biomaterials
have
emerged
as
promising
strategies
in
biomedical
research
and
engineering
domain,
offering
unique
characteristics
for
tissue
regeneration,
drug
delivery,
therapeutic
interventions,
cellular
investigations.
The
ECM,
a
dynamic
network
structure
secreted
various
cells,
primarily
comprises
diverse
proteins
capable
of
facilitating
tissue-ECM
signaling
regulatory
functions
through
its
rich
array
bioactive
substances
multi-level
structural
properties.
Drawing
inspiration
from
intricate
biochemical
composition
natural
researchers
developed
to
encapsulate
these
features
create
biomimetic
microenvironments,
such
electrospinning,
hydrogels/hydrogel
microspheres,
decellularized
ECM(dECM),
ECM-mimicking
peptides.
Furthermore,
mimicking
ECM
components,
ECM-inspired
exhibit
varying
degrees
functionalization,
including
providing
support,
cell
adhesion,
signal
transduction,
mitigating
immune
responses,
remodeling.
In
summary,
advancements
offer
significant
promise
addressing
key
challenges
fields
engineering,
regenerative
medicine,
delivery.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(19)
Опубликована: Март 19, 2024
The
treatment
of
infected
wounds
remains
a
challenging
biomedical
problem.
Some
bioactive
small-molecule
hydrogelators
with
unique
rigid
structures
can
self-assemble
into
supramolecular
hydrogels
for
wound
healing.
However,
they
are
still
suffered
from
low
structural
stability
and
bio-functionality.
Herein,
hydrogel
antibacterial
dressing
dual
nanofibrillar
network
structure
is
proposed.
A
created
by
hydrogelator,
puerarin
extracted
the
traditional
Chinese
medicine
Pueraria,
interconnected
secondary
macromolecular
silk
fibroin
induced
Ga
ions
via
charge-induced
self-assembly.
resulting
features
adequate
mechanical
strength
sustainable
retention
at
wounds.
Good
biocompatibility
efficient
bacterial
inhibition
obtained
when
ion
concentration
0.05%.
Otherwise,
substantial
release
endows
excellent
hemostatic
antioxidative
properties.
In
vivo,
evaluation
mouse-infected
model
demonstrates
that
its
healing
effect
outperformed
commercially
available
silver-containing
dressing.
experimental
group
successfully
achieves
100%
closure
rate
on
day
10.
This
study
sheds
new
light
design
based
self-assembly
naturally
derived
molecules
as
well
their
clinical
use
treating
chronic
Pharmaceutics,
Год журнала:
2022,
Номер
15(1), С. 68 - 68
Опубликована: Дек. 26, 2022
Wound
dressing
is
an
important
tool
for
wound
management.
Designing
dressings
by
combining
various
novel
materials
and
drugs
to
optimize
the
peri-wound
environment
promote
healing
a
concept.
Hydrogels
feature
good
ductility,
high
water
content,
favorable
oxygen
transport,
which
makes
them
become
some
of
most
promising
dressings.
In
addition,
nanomaterials
exhibit
superior
biodegradability,
biocompatibility,
colloidal
stability
in
can
play
role
promoting
through
their
nanoscale
properties
or
as
carriers
other
drugs.
By
advantages
both
technologies,
several
outstanding
efficient
have
been
developed.
this
paper,
we
classify
nano-based
hydrogel
into
four
categories:
loaded
with
nanoantibacterial
drug;
oxygen-delivering
nanomedicines;
nanonucleic
acid
drugs;
nanodelivered
The
design
ideas,
advantages,
challenges
these
are
reviewed
analyzed.
Finally,
envisaged
possible
future
directions
context
relevant
scientific
technological
advances,
hope
will
inform
further
research
Abstract
The
skin
plays
a
fundamental
role
in
regulating
the
body’s
internal
balance
and
protecting
against
external
traumas.
A
broad
variety
of
environmental
risk
factors
frequently
result
acute
wounds,
whose
inappropriate
treatments
would
lead
to
chronic
wounds
that
are
difficult
heal.
Traditional
dressings
have
been
widely
used
repair
however
their
drawbacks
such
as
insufficient
hemostatic
efficacy
non-moist
environment
severely
limited
clinical
applications.
As
principal
component
skin,
collagen
has
always
research
hotspot
field
due
its
advantages
low
antigenicity,
high
biocompatibility
superior
bioactivity.
Collagen-based
increasingly
developed
heal
during
past
decades,
arising
from
capability
decreasing
protein
electrolyte
losses
wound
exudate,
preventing
bacterial
contamination,
permitting
less
painful
dressing
changes,
improving
healing
quality.
This
review
overviews
recent
progress
for
healing.
Various
commonly
management
first
introduced.
Collagen
categorized
films,
sponges,
hydrogels,
nanofibers,
powders,
compared.
critical
functions
healing,
stopping
bleeding,
shortening
inflammation,
promoting
angiogenesis,
stimulating
tissue
regeneration
elaborated.
applications
different
types
thoroughly
summarized.
comprehensive
list
commercialized
updated,
an
outlook
finally
speculated.
Graphical
Polymeric
materials
have
found
increasing
use
in
biomedical
applications
the
last
decades.
Among
them,
hydrogels
represent
chosen
class
of
to
this
field,
particular
as
wound
dressings.
They
are
generally
non-toxic,
biocompatible,
and
biodegradable,
they
can
absorb
large
amounts
exudates.
Moreover,
actively
contribute
skin
repair
promoting
fibroblast
proliferation
keratinocyte
migration,
allowing
oxygen
permeate,
protecting
wounds
from
microbial
invasion.
As
dressing,
stimuli-responsive
systems
particularly
advantageous
since
be
active
only
response
specific
environmental
stimuli
(such
pH,
light,
ROS
concentration,
temperature,
glucose
level).
In
review,
we
briefly
resume
human
skin’s
structure
functions,
well
healing
phases;
then,
present
recent
advances
hydrogels-based
Lastly,
provide
a
bibliometric
analysis
knowledge
produced
field.
Materials Horizons,
Год журнала:
2023,
Номер
10(9), С. 3237 - 3256
Опубликована: Янв. 1, 2023
This
work
highlights
the
animal
tissue-derived
biomaterials
in
wound
treatment
field
based
on
an
evaluation
of
their
critical
properties,
advanced
design
strategies
and
latest
applications.
Molecules,
Год журнала:
2023,
Номер
28(20), С. 7039 - 7039
Опубликована: Окт. 12, 2023
Large
bone
defects
due
to
trauma,
infections,
and
tumors
are
difficult
heal
spontaneously
by
the
body’s
repair
mechanisms
have
become
a
major
hindrance
people’s
daily
lives
economic
development.
However,
autologous
allogeneic
grafts,
with
their
lack
of
donors,
more
invasive
surgery,
immune
rejection,
potential
viral
transmission,
hinder
development
repair.
Hydrogel
tissue
bioengineered
scaffolds
gained
widespread
attention
in
field
good
biocompatibility
three-dimensional
network
structure
that
facilitates
cell
adhesion
proliferation.
In
addition,
loading
natural
products
nanoparticles
incorporating
them
into
hydrogel
is
one
most
effective
strategies
promote
bioactivity
limitations
products.
Therefore,
this
paper
presents
brief
review
application
hydrogels
different
gel-forming
properties,
matrices,
nanoparticle-loaded
loaded
incorporated
for
defect
recent
years.
