Bone‐Targeted Fluoropeptide Nanoparticle Inhibits NF‐κB Signaling to Treat Osteosarcoma and Tumor‐Induced Bone Destruction DOI Creative Commons
Lin Li, Guangyu Rong, Xīn Gào

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract Osteosarcoma is a malignant bone cancer usually characterized by symptoms of loss due to pathologically enhanced osteoclast activity. Activated osteoclasts enhance resorption and promote osteosarcoma cell progression secreting various cytokines. Intercepting the detrimental interplay between cells considered as an option for treatment. Here, bone‐targeted fluoropeptide nanoparticle that can inhibit nuclear factor kappa B (NF‐κB) signaling in both address above issue developed. The NF‐κB essential modulator binding domain (NBD) peptide conjugated with fluorous tag improve its proteolytic stability intracellular penetration. NBD efficiently delivered into after fluorination induce apoptosis osteocarcoma cells, inhibits differentiation. fluorous‐tagged further co‐assembled oligo (aspartic acid) terminated form nanoparticles targeted inhibited tumor osteosarcoma‐induced destruction vivo. This nanoplatform proposed this study offers promising approach delivery therapeutics treatment diseases.

Язык: Английский

Effective Intracellular Delivery of mRNA by Progressive Cell Deformation in Viscoelastic Microfluidics DOI
Qiang Zhao, Minhui Liang, Ye Ai

и другие.

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137953 - 137953

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Fluorous-tagged Bortezomib Supramolecular Nanomedicine for Cancer Therapy DOI Creative Commons
Changping Wang,

Xin Gao,

Zhan Li

и другие.

Supramolecular Materials, Год журнала: 2024, Номер unknown, С. 100080 - 100080

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

2
Bone‐Targeted Fluoropeptide Nanoparticle Inhibits NF‐κB Signaling to Treat Osteosarcoma and Tumor‐Induced Bone Destruction DOI Creative Commons
Lin Li, Guangyu Rong, Xīn Gào

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract Osteosarcoma is a malignant bone cancer usually characterized by symptoms of loss due to pathologically enhanced osteoclast activity. Activated osteoclasts enhance resorption and promote osteosarcoma cell progression secreting various cytokines. Intercepting the detrimental interplay between cells considered as an option for treatment. Here, bone‐targeted fluoropeptide nanoparticle that can inhibit nuclear factor kappa B (NF‐κB) signaling in both address above issue developed. The NF‐κB essential modulator binding domain (NBD) peptide conjugated with fluorous tag improve its proteolytic stability intracellular penetration. NBD efficiently delivered into after fluorination induce apoptosis osteocarcoma cells, inhibits differentiation. fluorous‐tagged further co‐assembled oligo (aspartic acid) terminated form nanoparticles targeted inhibited tumor osteosarcoma‐induced destruction vivo. This nanoplatform proposed this study offers promising approach delivery therapeutics treatment diseases.

Язык: Английский

Процитировано

1