Design and fabrication of melphalan (MPN) and vincristine (VCR) loaded carboxymethyl chitosan (CMC) nanoparticles for promising antibacterial and anticancer therapy in liver cancer cells

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 144421 - 144421

Опубликована: Май 1, 2025

Язык: Английский

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In situ injectable self-healing hydrogel of 5-fluorocytidine-modified chitosan with antifungal and antibacterial properties for promoting wound healing

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 315, С. 144321 - 144321

Опубликована: Май 21, 2025

Язык: Английский

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Recent progress of methods for cuproptosis detection

Frontiers in Molecular Biosciences, Год журнала: 2024, Номер 11

Опубликована: Сен. 4, 2024

Varying from other identified cell death pathways, cuproptosis is a new type of regulated characterized by excess Cu ions, abnormal aggregation lipoylated proteins in TCA cycle, loss Fe-S cluster proteins, upregulation HSP70, leading to proteotoxic and oxidative stress. Cuproptosis highly concerned scientific community as the field further develops, remarkable progress has been made verification mechanism cuproptosis, methods used detect have continuously improved. According characteristic changes techniques based on verification, content, morphology, molecular biology protein levels cuproptosis-related molecules biochemical pathways enzyme activity metabolites stress, lipoic acid, phosphorylation, respiration intensity subject research. In order deepen understanding detecting principle application common detection are reviewed categorized cellular phenomena terms death, biology, with flow chart. All indicating results displayed response markers their advantages limitations summaried, comparison ferroptosis performed this study. Our collection for will provide great basis research future.

Язык: Английский

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From experimental studies to computational approaches: recent trends in designing novel therapeutics for amyloidogenesis

Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

This review highlights the integration of various experimental and computational methods to control amyloid aggregation process. We believe that this article will help researchers develop novel therapeutic influence protein aggregation.

Язык: Английский

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Inhibiting insulin aggregation by chaperone-like green cholinium-based DESs as additives

Journal of Molecular Liquids, Год журнала: 2024, Номер 407, С. 125274 - 125274

Опубликована: Июнь 13, 2024

Язык: Английский

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